Most popular brand: Claritin
Active ingredient: Loratadine
Available dosage forms: 10 mg
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Loratadine general information
Loratadine helps millions of allergy sufferers all over the world every day, and taken correctly, it can supply you with relief. I’m so happy I discovered this cat sneezing cure! Although loratadine 10mg tablets are not going to cure or grow your immunity to your own allergies, they permit you to control your allergy symptoms so you can return to living your daily life. In case you have a significant allergy attack, taking loratadine won’t help reduce the attack to any extent. These all-natural antihistamines may not only lower the intensity of allergy, but might handle the condition in the very long run too.
The strategies vary based on the acuteness along with the rosacea subtype that a specific person might be suffering from. There are sure decongestants including pseudoephedrine and antihistamines for example loratadine, which might be prescribed to cure the infections. The rash and itching begin 24 to two days after exposure, worsening through the upcoming several days. Besides side effects, it’s significant to contemplate certain conditions which could bring about complications while taking loratadine. A couple of nutrients with excellent antihistamine properties are mentioned below.
There are numerous remedies for rosacea people. Itching skin bumps can likewise be caused by means of a disease generally known as scabies. Acne is just another frequent problem among adolescents that can lead to the appearance of red bumps. In laser cure, light was designed to infiltrate the epidermis.
Yeast infection, known also as is an infection resulting from group of microscopic fungi or yeast. Lactose intolerance is just another cause of bloating. It is quite necessary that the cause of bloating is suitably detected. If this layer gets damaged at all, the body begins to develop symptoms, for example severe autoimmune conditions.
Antibiotics are used to treat many infections and diseases. It really can be caused by the utilization of opiates and even alcohol in big doses. Lipitor is a favorite medication since it works. Aller-Tec is among these allergy relief medicines.
Singulair can be properly used for remedying asthma symptoms in kids. Before using almost any allergy medications, please talk with your physician. If you’re prone to allergies, you aren’t giving your own immune system an opportunity to attack your allergies and eliminate them. For a much more severe reaction, prescription medication might be needed. Loratadine is a long-acting tricyclic antihistamine which is used to take care of allergies.
Corticosteroids are primarily used for lessening the inflammation brought on by an allergic reaction. In any case, corticosteroids hormone is employed to lower the inflammation and itching within the nasal passages. Heat lessens the accumulation of blood within the swollen region and thus decreases the swelling. They also induce dryness in your eyes and mouth, together with headaches. Apply a medicated lip balm so as to reduce dryness. This will lessen the swelling.
Migraines can lead to perioral numbness, in other words, numbness round the mouth in certain individuals. In extreme cases, since it’s in bleeding hemorrhoids, the physician can choose the sufferer through surgical procedures for example rubber banding. These could at times be serious conditions, as well as an individual showing numerous symptoms ought to have a health check-up done.
Description of the active ingredient loratadine / Loratadine.
Formula: C22H23ClN2O2, chemical name: Ethyl 4 – (8 – chloro – 5,6 – dihydro – 11H – benzo – [5,6] cyclohepta [1,2 – b] pyridine – 11 – ylidene) – 1 – piperidinecarboxylate
Pharmacological group: Intermedianty / histaminergic agents / gistaminolitiki / blockers of histamine H1 – receptor
Mode of action:. antihistamine, antiekssudativnoe, antiallergic, antipruritic.
Loratadine selectively blocking histamine H1 – receptors and prevents the effects of histamine on smooth muscles and blood vessels, reduces the permeability of capillaries, slows exudation, reduces erythema and itching. Loratadine easier and prevents the development of allergic reactions. The effect is 1-3 hours, peaking at 8-12 hours, and save at least a day. Loratadine has weak bronchodilator activity. When using loratadine for 4 weeks thereto tolerance does not develop. Loratadine has no effect on the central nervous system (with its metabolites Loratadine can not penetrate the blood-brain barrier) and QT interval on the electrocardiogram.
In animal experiments found no effects on fertility in male and female rats, as well as a mutagenic effect. At doses of 40 mg / kg (mice) and 25 mg / kg (rats) loratadine induce microsomal liver enzymes, and long-term treatment with the drug cases of the appearance of hepatocellular tumors were noted.
The ingestion loratadine is rapidly absorbed. The maximum blood concentration is reached after 1.3 hours, and descarboethoxyloratadine (active metabolite) – 2.5 hours. Eating a significant effect on the pharmacokinetics of loratadine does not have, but slows down the time to reach maximum concentration of 1 hour (this is why the drug is recommended to produce before eating). Protein binding is 97% in the plasma loratadine concentration 2,5-100 ng / ml. The equilibrium concentrations of loratadine with its active metabolite are reached by day 5 of use of the drug. Loratadine in the liver under intense biotransformation involving cytochrome P450 system with the formation of the active metabolite – descarboethoxyloratadine. Per day excreted in the urine of 27% of the total dose of the drug conjugates of hydroxylated and / or metabolites. After 10 days about 80% of drug is excreted as metabolites equally with faeces (40%) and urine (40%). Half-life of loratadine is 3 – 20 hours (averaging about 8.4 hours), and the active metabolite – 8.8 – 92 hours (average – 28 hours). Clearance loratadine is 142-202 ml / min / kg, the volume of distribution – 119 l / kg. Loratadine easily passes into breast milk. In patients with chronic renal failure (creatinine Cl at least 30 ml / min) and the maximum concentration AUC loratadine increased (by 120% and 73% respectively), the half-life remains unchanged. Hemodialysis significant effect on the pharmacokinetics of loratadine does not have. In alcoholic liver lesion AUC and maximum concentration of loratadine increased by 2 times, and the active metabolite are not altered, half-life of loratadine is 24 hours, and the active metabolite – 37 hours. In elderly people, and the maximum concentration indicators loratadine and descarboethoxyloratadine AUC increased by 50%, while the half-life of loratadine and its active metabolite equal to 18.2 hours and 17.5 hours, respectively.
Allergic rhinitis (seasonal and year-round); allergic conjunctivitis; hay fever; chronic idiopathic urticaria; angioedema; pruritic dermatoses (chronic eczema, contact allergodermatity); asthma (as an additional tool); pseudoallergy reaction gistaminoliberatory; allergic reactions to insect stings.
How to use loratadine and dose
loratadine taken orally before a meal. Children over 12 years of age or with body weight over 30 kg and adults – 1 time per day to 10 mg. Babies 2 – 12 times per day -1 5 mg. In renal (if Cl creatinine less than 30 mL / min) or hepatic failure initial dose is 10 mg every other day or 5 mg daily.
When you pass another receiving loratadine take it as remember the following method through produce the specified time from the last use. It is recommended to cancel the therapy loratadine no less than 1 week prior to skin test allergens.
Hypersensitivity, age up to 2 years, breast-feeding.
Restrictions on the use
Pregnancy and breastfeeding
During pregnancy, you can use loratadine if the expected benefit to the mother above the potential risk to the fetus. Stop breast-feeding during treatment loratadine.
Side effects of loratadine
digestive system: dry mouth, increased appetite, weight gain, nausea, anorexia, changes in salivation, toothache, taste disturbance, stomatitis, gastritis, vomiting, bloating, constipation or diarrhea, dyspepsia very rarely – hepatitis, jaundice, hepatic necrosis;
nervous system: headache, drowsiness, fatigue, impaired concentration, nervousness, dizziness, anxiety, agitation, insomnia, amnesia, syncope, depression, tremor, hyperkinesia, paresthesia, hoarseness, hypoesthesia, change lacrimation, blurred vision, blepharospasm, conjunctivitis, tinnitus, pain in the eyes and ears, very rarely – seizures;
respiratory system: sneezing, stuffy nose, dry nose, sinusitis, epistaxis, laryngitis, pharyngitis, cough, bronchitis, coughing up blood, chest pain, bronchospasm, dyspnea, upper respiratory tract infection;
urogenital system: tenesmus, change in urine color, dysmenorrhea, vaginitis, menorrhagia, impotence, weakening of libido, edema;
support system and traffic: back pain, myalgia, arthralgia, convulsions calf muscles;
allergic reactions: a skin rash, redness, hives, itching, dermatitis, angioedema, anaphylaxis;
circulatory system: palpitations, hypertension or hypotension, tachycardia, supraventricular tachyarrhythmia;
other: dry skin and hair, thirst, malaise, asthenia, fever, photosensitivity, fever, excessive sweating, breast pain, weight gain, alopecia, erythema multiforme, an increase in the size of the chest.
loratadine interaction with other substances
ketoconazole and erythromycin, cimetidine increases the blood levels of loratadine and its active metabolite. Loratadine erythromycin lowers plasma by 15%. Loratadine does not increase the effects of alcohol on the central nervous system.
In the case of loratadine overdose occur: headache, tachycardia, drowsiness; children weighing less than 30 kg received 10 mg of a syrup noted palpitations, extrapyramidal disorder. Required: syrup of ipecac to induce vomiting, gastric lavage, take activated charcoal, holding symptomatic and supportive treatment. Hemodialysis is ineffective.
Trading names of drugs with working substance loratadine
Alerpriv® Vero – Loratadine Klallergin
Klargotil® Klaridol Klarisens®
Solo Lomilan® LoraGEKSAL®
Loratadine Loratadine 10 – SL
Loratadine – OBL
Loratadine – Loratadine Verte
Teva Loratadine – Hemofarm
Loratadine – Stada Lothar