Buy Generic Fosamax (Alendronate) 5, 10, 35, 70 mg online

 • Alendronate general information

      • Active – active substance / start: alendronate (alendronate sodium)

      • alendronate (alendronate sodium)

Fosamax Alendronate 5, 10, 35, 70 mg
Most popular brand: Fosamax
Active ingredient: Alendronate
Available dosage forms: 5, 10, 35, 70 mg
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Alendronate general information

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Steer clear of self medication as excess calcium within your body might result in many health complications. Examples include taking particular antacids and also water pills that may lead to nutrient deficiencies causing muscle weakness and other relevant symptoms. Additionally, It has been applied along with and calcium for the therapy and avoidance of osteoporosis that’s corticosteroid-related. For strong bones, sufficient quantity of calcium ought to be included within the daily diet.

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Edema means retention or accumulation of extra fluid within the tissues. Patients should additionally not lie down for half a hour after swallowing the tablets. Constipation for prolonged time period can cause stomach ulcers, pain and bloating. This is an important symptom of heartburns. There is absolutely no solitary known cause for this particular condition.

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Active – active substance / start: alendronate (alendronate sodium)

alendronate sodium; Alendronate Pliva; Alendronic acid; Lindron; Ostalon; Ostealen; Ostemaks; Strongos; Tevanat; Foroza; Fosamax.

alendronate (alendronate sodium) – bisphosphonate; Corrector metabolism of bone tissue; effective non-hormonal specific inhibitor of osteoclastic bone resorption. It stimulates bone formation and restores a positive balance between bone resorption and bone repair, progressively increases mineral density of bones in the spine, pelvis and other bones of the skeleton, promotes formation of bone tissue with normal histological structure. It is used to treat osteoporosis in postmenopausal women (postmenopausal osteoporosis), and osteoporosis in men (senile osteoporosis) in order to prevent fractures, Paget’s disease (osteitis deformans), hypercalcemia of malignancy.

Active – active substance:
Alendronic acid / sodium Alendronate / Alendronic acid / Alendronate sodium.

Dosage Forms:
Tablets.

alendronate (alendronate sodium)

Properties / Action:
alendronate (alendronate sodium) – Corrector metabolism of bone tissue; effective non-hormonal specific inhibitor of osteoclastic bone resorption.
Alendronic acid is an amino – bisphosphonate. Bisphosphonates are synthetic analogs of pyrophosphate, hydroxyapatite binding, a part of bone tissue. Antirezorbiruyuschego mechanism of action is associated with inhibition of osteoclast function. In preclinical studies it has been shown tropism alendronate the active sites of bone resorption.
Alendronic acid stimulates bone formation and restores a positive balance between bone resorption and bone repair, progressively increases mineral density of bones in the spine, pelvis and other bones of the skeleton, promotes formation of bone tissue with normal histological structure.

Pharmacokinetics:
The bioavailability of alendronate in women when administered on an empty stomach at least 2 hours before lunch standarnogo (in doses ranging from 5 to 70 mg) of 0.64%, from men – 0.6%. Bioavailability is reduced by about 40% when taking alendronate fasting for 1 – 1.5 hours before a standardized breakfast. In general, the effectiveness of alendronate sufficient if taken at least 30 minutes before the first meal. The bioavailability of alendronate negligible as it is received together with a meal or within 2 hours after ingestion. Upon receipt of alendronate with coffee or orange juice reduced bioavailability by approximately 60%. The average distribution volume in a state of equilibrium concentration in humans is about 28 liters. Distributed in the soft tissue, and then rapidly redistributed to bone, where it is binding, or excreted in the urine. Alendronic acid concentration in plasma – less than 5 ng / ml. Plasma protein binding is approximately 78%. Alendronic acid is not metabolized in the body. After a single intravenouslytroduction of alendronate, approximately 50% is excreted in the urine within 72 hours; excretion in the feces is negligible. Renal clearance – 71 ml / min, System – 200 ml / min. After 6 hours after on / in the plasma concentration is reduced more than 95%. In patients with impaired renal function may be expected somewhat larger accumulation of alendronate in bone. Terminal half-life of alendronate in humans than 10 years, which corresponds to the time of removal of the bones of the skeleton.

Indications:

  • the treatment of osteoporosis in postmenopausal women (postmenopausal osteoporosis) in order to prevent fractures, including hip fractures and spinal compression fractures;
  • the treatment of osteoporosis in men (senile osteoporosis) in order to prevent fractures;
  • Paget’s disease (osteitis deformans);
  • hypercalcemia due to malignancy (malignant hypercalcemia, additional treatment).

    Dosage and administration:
    drugs alendronate prescribed only for adults.
    Preparations alendronate should be taken at least half an hour before the first food, drink or any drugs, drinking only a full glass of plain water because other drinks (including mineral water), food and medications can reduce the absorption of alendronate. One can not chew the tablet or dissolve in the mouth, because it is at risk of ulceration of the oral cavity and pharynx.
    To ensure getting the tablet to the stomach and thus reduce the potential irritant effect of alendronate on the esophagus, it is necessary to take the drug after morning rise from the bed, with a full glass of water. Thus patients after ingestion should not place at least 30 minutes prior to the first day for ingestion. Alendronic acid should not be taken at bedtime or before the morning rise from the bed. Failure to comply with the conditions of the drug may increase the risk of negative effects on the esophagus.
    treatment of osteoporosis in postmenopausal women and men: the recommended dosage of 70 mg once per week or 10 mg once a day.
    When Paget’s disease – 40 mg / day for 6 months.
    alendronate dosage adjustments are not required or for elderly patients or for patients with mild to moderate renal insufficiency (creatinine clearance 35 to 60 mL / min). In the absence of data alendronate is not recommended for use in patients with more severe renal insufficiency (creatinine clearance = 1%:

    alendronate 70 mg / once a week.

    alendronate 10 mg / once a day.

    Special instructions and precautions:
    Alendronic acid, like other bisphosphonates, may cause local irritation of the upper gastro – intestinal tract. In some cases, side effects were pronounced, and required hospitalization. In this connection it is necessary to examine with special attention to any signs or symptoms suggestive of the possibility of reaction on the part of the esophagus. Patients should be informed about the need to stop taking alendronate and seek medical help if symptoms of esophageal disease: difficulty or pain when swallowing (dysphagia), chest pain, new or worsening heartburn. The risk of serious side effects on the esophagus, is likely to be higher in patients who lie down after taking alendronic acid and / or are taking medication is not washing it down with full glass of water, and / or continue taking the drug after the development of symptoms characteristic of esophageal irritation. Thus, it is a very important clarification of the rights of patients receiving alendronate and draw attention to the need for their strict compliance. In connection with a possible irritant effect of alendronate on the upper gastrointestinal mucosa – intestinal tract, caution must be exercised in the appointment of alendronate patients with acute upper gastrointestinal diseases – intestinal tract, such as dysphagia, oesophageal disease, gastritis, duodenitis or ulcer.
    The patient should be informed that if you accidentally missed doses at a dosage of 1 time per week (70 mg), should take 1 tablet in the morning the next day. Do not take 2 tablets in one day, but in the future we need to continue to take 1 tablet on the day of the week, which has been selected for admission to the start of treatment.
    Combined use of alendronate with estrogen drugs (but not simultaneous reception) is not accompanied by a change in their actions and the development of side effects.
    It is necessary to take into account other causes of osteoporosis not associated with estrogen deficiency and aging. It does not investigate the effect of alendronate for the treatment of osteoporosis caused by taking corticosteroids.
    In the presence of hypocalcemia is necessary to conduct its correction before treatment alendronate. Patients with other disorders of mineral metabolism (such as a deficiency of vitamin D) should receive the full appropriate treatment. Due to the fact that Alendronic acid increases mineral content in bones, may have a slight asymptomatic reduction of calcium and phosphate in the serum (including patients receiving corticosteroids, whose calcium absorption can be lowered). In this case, to ensure an adequate supply of vitamin D and calcium with the food or in the form of drugs.
    In clinical studies, there was no age-related differences in the efficacy and safety of alendronic acid.
    alendronate is not administered to patients with rare hereditary diseases – galactose intolerance, lactase deficiency or glucose – galactose malabsorption.

    Effects on ability to drive and use other mechanisms:
    Alendronic acid does not affect the ability to drive and operate potentially dangerous machinery.

    Drug Interactions:
    Special studies alendronate interactions with other drugs have not been conducted.
    interval between reception of alendronic acid and others. medicaments should be at least 30 minutes.
    calcium preparations, antacids, and some other means taken by mouth, can affect the absorption of alendronate if taken at one and the same time.
    NSAIDs (indomethacin. . and others.) increase gastrotoxicity alendronate.
    increases the bioavailability of 2 times (the clinical significance is not defined).
    Reception and into healthy volunteers is not accompanied by clinically significant changes in the bioavailability of alendronate.
    The combined use gormonzameschayuschey therapy (estrogen / progestin) and alendronate has been studied in two clinical trials lasting 1 or 2 years with the participation of postmenopausal women with osteoporosis. Using this combination resulted in a greater increase in bone mass and a significant reduction of bone resorption compared to the separate use of the first or second treatment. In these studies the safety profile and tolerability of combination therapy correspond to those in the application of each of these treatments on their own.
    Other drug interactions with clinical significance, are not supposed to.

    Storage:
    List B. Store at room temperature (15 – 25 ° C) in a dry, protected from light, out of reach of children.
    The expiration date on the package. Do not use beyond the expiration date.
    Terms of pharmacy holiday – by prescription.

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