Most popular brand: Furadantin
Active ingredient: Nitrofurantoin
Available dosage forms: 100 mg
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Nitrofurantoin general information
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The antimicrobial agent of a wide spectrum of action, a derivative of nitrofuran. It has bacteriostatic and bactericidal action with urinary tract infections. Nitrofurantoin is active against Escherichia coli, Klebsiella spp. Enterobacter spp. spp Proteus.
It is effective mainly for urinary tract infections.
Well absorbed from the gastrointestinal tract. Bioavailability is 50% (food increases the bioavailability). The rate of absorption depends on the crystal size (microcrystalline form is characterized by rapid dissolution and absorption of speed, short time to achieve C max in the urine). Communication with plasma proteins – 60%. It is metabolized in the liver and muscle tissue. T 1/2 – 20 – 25 minutes. It penetrates the GEB, placental barrier, excreted in breast milk. Displays fully kidneys (30 – 50% – unchanged).
The infectious – inflammatory diseases of urinary tract infections (including pyelonephritis, cystitis) caused by organisms susceptible to nitrofurantoin.
The dose for adults is 50 – 100 mg, the multiplicity of applications – 4 times / day. The daily dose for children – 5 – 7 mg / kg for 4 doses. Duration of treatment – 7 days. If necessary, possible to continue treatment for another 3 days (only after the urine for sterility control). During the long-term maintenance treatment of nitrofurantoin dose should be reduced.
The respiratory system: chest pain, cough, shortness of breath, pulmonary infiltrates, eosinophilia, interstitial pneumonitis or fibrosis, reduced respiratory function, bronchial asthma attack in patients with asthma history.
From the digestive system: epigastric discomfort, anorexia, nausea, vomiting; rarely – hepatitis, cholestatic jaundice, abdominal pain, diarrhea.
From the central and peripheral nervous system: peripheral neuropathy, headache, nystagmus, dizziness, drowsiness.
From the hematopoietic system: leukopenia, granulocytopenia, agranulocytosis, thrombocytopenia, hemolytic anemia, megaloblastic anemia (these changes are reversible).
Allergic reactions: urticaria, angioedema, pruritus, rash; very rarely – anaphylactic shock.
Dermatological reactions: exfoliative dermatitis, erythema multiforme.
Other: drug fever, arthralgia, there may be flu-like symptoms, superinfection urinary tract, often caused by Pseudomonas aeruginosa.
Expressions of renal excretory function, renal failure, oliguria, glucose deficiency – 6 – phosphate dehydrogenase, pregnancy, early childhood (up to 1 month), increased sensitivity to nitrofurantoin, cardiac insufficiency II – III stage, liver cirrhosis, chronic hepatitis B, acute porphyria, lactation.
Application of pregnancy and breast-feeding
Nitrofurantoin is contraindicated during pregnancy and lactation (breastfeeding).
The risk of developing peripheral neuropathy is increased in patients with anemia, diabetes, electrolyte imbalance, lack of vitamins B, renal failure.
Nitrofurantoin should not be used to treat diseases of the renal cortex, with purulent paranephritis and prostatitis. Nitrofurantoin is not indicated in combination with drugs that cause renal dysfunction.
The simultaneous use of nalidixic acid, and antacids containing magnesium trisilicate reduces the antibacterial effect of nitrofurantoin.
nitrofurantoin incompatible with fluoroquinolones.
With simultaneous use of drugs that block tubular secretion, reduce the antibacterial effect of nitrofurantoin (by reducing the concentration of nitrofurantoin in the urine) and increase its toxicity (increased concentration in the blood).
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