Last Updated on February 19, 2017 by Dr.Derek Fhisher

Allegra Fexofenadine 30, 120, 180 mg
Most popular brand: Allegra
Active ingredient: Fexofenadine
Available dosage forms: 30, 120, 180 mg
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Fexofenadine general information

Fexofenadine doesn’t easily traverse the blood-brain barrier, and because of this is not going to induce sleepiness. Vertigo is among the most ordinary health issues in adults. The chance of birth defects brought on by both of these ingredients is very low. Urticaria has four key mechanisms.

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In case you are presently taking any of these medications, then it’s essential your health care professional needs to be informed accordingly, particularly if you are taking any of these. If it’s a chronic circumstance, it is constantly advisable to seek advice from your physician immediately. Prior to taking any supplement, you should consult with a physician. That is, in addition, the reason it must be critical that you know type 2 diabetes symptoms. To acquire maximum benefit of the Isotretinoin prescribed dosage, superior food habits and an improved lifestyle ought to be followed combined with the treatment.

Blood tests and liver tests should be performed regularly, to confirm the progress and also to keep your eye on the after effects. Although they don’t accelerate the recovery, following expectorants are not likely to have some side effects even when mixed with several other medicines. Aside from side effects, it’s essential to take into account certain conditions which could bring about complications while taking loratadine. Despite its use, there are specific loratadine after effects an user have to know of.

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It was placed in the marketplace in 1984. It is likewise obtainable in the liquid form. In children, intake of the medicine can cause the development of conjunctivitis.

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Active – active substance / start: fexofenadine

Telfast; Feksadin; Feakes; Feksofast; Fexofenadine; Fexofenadine hydrochloride.

Fexofenadine – antihistamines, non-sedating highly effective and safe blocker H1 – histamine receptors. It is an active metabolite of terfenadine. It stabilizes mast cell membranes, which reduces the release of histamine and other biologically active substances. Effect after oral administration lasts about 24 hours. No sedative effect, has no effect on psychomotor reactions it lacks cardiotoxicity. After 28 days of treatment were observed getting used to. It is used to treat allegicheskih diseases: allergic rhinitis (including hay fever or hay fever), conjunctivitis, urticaria and angioedema .

Active – active substance:
fexofenadine / Fexofenadine.

Dosage Forms:
Tablets.

Fexofenadine

Properties / Action:
Fexofenadine – blocker H1 – receptors; active metabolite of terfenadine is a racemic mixture of two pharmacologically active isomer.
Fexofenadine – non-sedating antihistamine vysokoeffektivenoe antiallergic agent.
Fexofenadine has been thoroughly investigated, including under clinical conditions. As was shown in experiments in vitro and in vivo, Fexofenadine is highly specific and potent inhibitor of H1 – histamine receptors. It has about 2-fold greater affinity to H1 – receptors as compared to terfenadine. Histamine released from mast cells and basophils, causes many of the clinical symptoms associated with allergic rhinitis (such as sneezing, itching and rhinorrhea) and urticaria, through its effect on H1 – receptors. Furthermore, fexofenadine stabilizes mast cell membranes, which reduces the release of histamine and other biologically active substances.
fexofenadine exhibits virtually no other pharmacological activity. There was found no activity on dopamine receptors ovyh or anticholinergic, antiadrenergic, analgesic, anticonvulsant and antidepressant activity.
slow fexofenadine not block potassium currents and therefore does not cause QT interval changes. In patients taking fexofenadine, no significant changes in the QT interval compared to patients taking placebo (comparable to placebo on the manifestation of cardiotoxicity).
Fexofenadine has no effect on the central nervous system. Not registered pronounced behavioral effects or any – any changes bedtime or motor coordination. Fexofenadine does not have a sedative effect, has no effect on psychomotor reaction even at doses higher than recommended.
fexofenadine does not cause clinically significant interactions when co-administration with drugs metabolized in the liver.
Fexofenadine has a rapid onset of action. The antihistamine effect begins to appear within the first hour after administration, reaching a peak after 6 hours. Effect after oral administration lasts about 24 hours, allowing it to take one time a day. The dosage range of 10 – 130 mg dose-dependent effect observed. Clinical studies have shown that a dose of 120 mg is sufficient for 24 – hour effectiveness of Fexofenadine.
Studies conducted on patients at risk (elderly, and patients with impaired renal or hepatic function), have shown that they do not need to carry out a correction dose of Fexofenadine.
With prolonged use Fexofenadine cumulation is not observed and does not develop tolerance. After 28 days of treatment were observed getting used to.

Pharmacokinetics:
Fexofenadine is rapidly absorbed from the gastrointestinal tract when taken orally, reaching a maximum concentration in plasma levels (Cmax) after 1 – 3 hours. The mean Cmax value after administration of a dose of 180 mg 1 time per day was approximately 494 ng / ml, and after administration of 120 mg – 427 ng / ml. Fexofenadine pharmacokinetics when administered at a dose of 120 g, 2 times a day is linear. The dose of 240 mg 2 times a day caused slightly greater than proportional increase (8.8%) AUC, which means that at these doses in the range between 40 mg and 240 mg, with daily intake Fexofenadine practically linear pharmacokinetics. Receiving Fexofenadine in doses of 15, 30 and 60 mg in children aged 6-11 years proportional with comparable mode of application in adults at a dose of 120 mg per day. Bioavailability is not less than 33%. Food intake did not significantly affect the absorption of fexofenadine, so the patient does not require dose adjustment. Plasma protein binding is 60 – 70%. It does not cross the blood-brain barrier. No significant biotransformation Fexofenadine was found. Not involving metabolized by cytochrome P450, undergoes biotransformation in the liver, does not interact with other drugs metabolized by the liver, such as erythromycin, ketoconazole ohms or ohms. On average 80% of the dose detected unchanged in the feces and urine of 10%. The only Fexofenadine metabolites detected in the faeces and urine, are small amounts of methyl fexofenadine and inactive decay product – azatsiklonola. The half-life of plasma is Fexofenadine in healthy individuals on average 11 – 15 hours after administration of multiple doses.
hepatic pathology has little effect on the absorption and elimination Fexofenadine. There is no need to correct the dose in patients with liver disease.

Indications:
Fexofenadine is used for the symptomatic treatment of allergic diseases:

  • allergic rhinitis, hay fever (hay fever);
  • chronic idiopathic urticaria, allergic urticaria, recurrent angioedema (angioedema).

    Dosage and administration:
    Fexofenadine appointed interior, regardless of the meal, with water.
    For the treatment of allergic rhinitis and hay fever (hay fever) in adults and children older than 12 years recommended dose of Fexofenadine 120 mg 1 time per day orally.
    For the treatment of chronic idiopathic urticaria in adults and children over 12 years is recommended once-daily dose of Fexofenadine 180 mg orally.
    No need for correction Fexofenadine doses in elderly patients and in patients with impaired liver and kidney function.
    The use in children aged 6 to 11 years inclusive. To eliminate the symptoms of of allergic rhinitis and chronic idiopathic urticaria in children in age from 6 to 11 years inclusive of the recommended dose is 30 mg Fexofenadine 1 – 2 times a day.
    Children with impaired renal function as recommended starting dose is 30 mg once daily appointment.

    Overdose:
    Reports of overdose of Fexofenadine are rare and contain limited information.
    Symptoms: dizziness, drowsiness, fatigue, a feeling of dryness in the mouth.
    Treatment: recommended conducting standard measures to remove unabsorbed drug from the gastrointestinal tract – gastric lavage, the appointment of activated carbon. laxatives. If necessary, symptomatic and supportive therapy. Hemodialysis is ineffective.

    Contraindications:

  • Individual intolerance (including a history of hypersensitivity) fexofenadine;
  • Children under 6 years of age (safety and effectiveness not defined);
  • pregnancy and lactation.
    Fexofenadine is used with caution:
  • abnormal liver function;
  • renal dysfunction in children.

    Use during pregnancy and lactation:
    There is no data on the effects of Fexofenadine in pregnant women. There are no adequate and well-controlled studies have been conducted, so Fexofenadine is not recommended during pregnancy.
    If necessary, use during lactation should decide the issue of termination of breastfeeding, because it was found that fexofenadine into breast milk.
    The use of Fexofenadine during pregnancy and lactation is possible if the expected effect of therapy outweighs the potential risk to the fetus and newborn.

    Side effects:
    From the nervous system: headache, fatigue, drowsiness, dizziness; in some cases – anxiety, sleep disturbance, taste disturbance.
    From the digestive system: dyspepsia, nausea, dry mouth.
    Other: rare – dryness of the nose and / or throat; in some cases – anaphylactic reactions, chest pain, photosensitivity reaction.
    In clinical trials, the incidence of adverse events (headache, drowsiness, nausea, dizziness and fatigue) while taking Fexofenadine was similar to the frequency of placebo.

    Special instructions and precautions:
    No need to adjust the dose of Fexofenadine in elderly patients, patients with renal or hepatic insufficiency.
    conducted clinical – pharmacological studies have demonstrated high efficacy and safety of Fexofenadine when used in doses of 30 mg and 60 mg per day in children aged 6 to 11 years inclusive. Efficacy and Safety of Fexofenadine use in children younger than 6 years have not been studied.

    Clinical trials:
    The pharmacological action and safety of Fexofenadine have been studied more than 4,000 patients with symptoms of allergy, 500 healthy volunteers and in subjects with hepatic or renal insufficiency. More than 470 people took part in the long-term study on its safety.
    The effectiveness of Fexofenadine in seasonal allergic rhinitis:

  • 120 mg 1 time per day provides a significant suppression of symptoms mediated by histamine;
  • 120 mg 1 time per day significantly alleviates the symptoms of allergic rhinitis;
  • relief of symptoms seen in the patient for 1 hour after oral dose of 120 mg, which is confirmed by the results of provocative tests to pollen;
  • 120 mg 1 time per day provides a clinically significant relief of symptoms, which lasts for 24 hours after ingestion;
  • 120 mg per day is comparable to the effectiveness of cetirizine th (10 mg daily) for the elimination of symptoms associated with seasonal allergic rhinitis.
    The effectiveness of Fexofenadine in chronic idiopathic urticaria:
  • in a dose of 180 mg 1 time per day provides a significant relief of symptoms of chronic idiopathic urticaria;
  • 79% of patients experienced relief of chronic idiopathic urticaria symptoms when given in a daily dose of 180 mg;
  • in a dose of 180 mg 1 time per day caused a significant relief of itching, reduced the number of blisters, reduced the impact of chronic idiopathic urticaria sleep and provides normal daily activity.
    The effectiveness of Fexofenadine against blisters and inflammatory hyperemia:
  • has a more rapid onset of action than loratadine for histamine-induced blisters and flushing.
    Safety and tolerability of Fexofenadine:
  • tolerance comparable to that of placebo at doses up to 690 mg twice daily for 28 days or 240 mg 1 time per day for 12 months;
  • no difference frequency of side effects were observed in subgroups, ranked by gender, age, race or weight;
  • had no significant effect on vital activity parameters, ECG and biochemical research data;
  • There were no dose-related increase in adverse effects, particularly registered increase side effects in the case when the dose was increased from 120 mg 1 time per day to 180 mg 1 time per day, or up to 240 mg twice day;
  • no dose-dependent increase in the incidence of sleepiness was observed when used in the treatment of seasonal allergic rhinitis and chronic idiopathic urticaria;
  • in doses of 120, 180 and 240 mg did not cause changes in symptoms or psychomotor reactions somnolence versus placebo; is the drug of choice for the treatment of allergies in individuals highly skilled labor;
  • very well tolerated and can be used without special precautions, such as a dose adjustment in the appointment of special categories of patients.

    Effects on ability to drive vehicles and management mechanisms:
    The effect of Fexofenadine reception on the ability to drive and perform work requiring high concentration and speed of psychomotor reactions, it is unlikely. However, before allowing the patient to check the individual response (possibility of non-standard reactions).
    Fexofenadine – truly non-sedating agent, without a significant increase in subjective sleepiness compared with placebo. Fexofenadine Investigation of the effect at doses up to 240 mg driving quality and psychomotor reactions carried out in comparison with placebo and clemastine ohm, which has a sedative effect. Fexofenadine for results were not different from placebo, whereas the volunteers treated clemastine, showed significant deterioration of psychomotor performance tests. The use of alcohol resulted in a deterioration of their performance, but sharing with fexofenadine alcohol was not inferior to the combination with placebo alcohol.
    The effect of Fexofenadine in the daily activity and psychomotor status was also investigated by the British agency for defense research and development (as part of the British Ministry of Defence; DERA). In determining the sensitivity of experimental research for the active control used promethazine (an antihistamine with a sedative effect). Unlike promethazine, fexofenadine not worked on psychomotor reactions and manifestations did not cause drowsiness as compared to placebo. Fexofenadine DERA found useful in the treatment of allergies in persons employed in automated production, and vehicle drivers. At the same time the study of cetirizine in similar experimental conditions showed that its therapeutic dose increased sleepiness compared with placebo, and so its use in a number of persons, such as airliners crew not recommended.

    Drug Interactions:
    Fexofenadine not biotransformed in the liver and therefore does not interact with other drugs metabolized by the liver.
    In the co-administration of Fexofenadine with erythromycin or ketoconazole its plasma concentration is increased by 2 – 3 times, which is connected, by – apparently with an increase in gastrointestinal absorption and the reduction or elimination of bile, or gastrointestinal secretion. These changes were not accompanied by effects on QT interval and were not associated with an increase in side effects compared with the drugs administered individually. Fexofenadine can be administered in conjunction with ketoconazole or erythromycin without adjusting the dose of each of the drugs. Purpose
    antacid preparations containing aluminum hydroxide and magnesium. 15 minutes prior to receiving Fexofenadine reducing its bioavailability is most likely due to binding in the gastro – intestinal tract. The recommended interval between taking fexofenadine and antacids should be at least 2 hours.
    The interaction between fexofenadine and omeprazole was observed th.
    With the simultaneous use of fexofenadine has no potentiating effect on ethanol or other drug with a depressing effect on the central nervous system.

    Storage:
    Store in a dry place inaccessible to children at temperature not above 25 ° C.
    The expiration date on the package.
    Terms of pharmacy holiday – without a prescription.

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