Last Updated on February 19, 2017 by Dr.Derek Fhisher
Most popular brand: Suprax
Active ingredient: Cefixime
Available dosage forms: 100, 200 mg
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Cefixime general information
They are able to reduce inflammative conditions like redness, swelling and soreness. In addition, They are helpful for several conditions like asthma and arthritis. In addition They can’t produce immunity.
It is beneficial to become rid of Scurvy disease. This is really a sort of calicivirus that may lead to epidemic gastroenteritis. Anti-biotics are regularly prescribed in combination to resist both diseases. This pill operates by inhibiting the procedure for protein synthesis within the bacteria cells. This pill operates by encouraging the bacteria cells’ capacity to form walls. This may lead to dehydration and electrolyte imbalance in the entire body.
Antibiotics are the sole known gonorrhea remedy. This drug is utilized for curing infections which are caused by bacteria. This drug is, in addition, used as a treatment for malaria. Among the very first antibiotics used when treating gonorrhea was penicillin. Fortunately enough, bacterial infections could be cured completely with the aid of antibiotics that can be found on the market. A number of the side effects brought on by these drugs also have been mentioned below.
In adults and kids, oral rehydration solutions ought to be administered to cope with the dehydration brought on by diarrhea and vomiting. Direct contact with bacteria within the stool, specially when changing diapers, intake of contaminated food as well as water, may lead to this intestinal infection. Intake of contaminated food and water is among the key causes of the bacterial infection. The infection-causing microorganisms within the gastrointestinal tract may lead to inflammation, besides a lot of other relevant symptoms. The infection is also well-known as shigellosis. To manage the diarrhea, Lomotil or Imodium might be given.
Gonorrhea is among the considerably more common sexually transmitted diseases. Complications from pelvic inflammatory illness can result in difficulties for instance chronic pelvic malady, ectopic pregnancy and infertility. In the same way, gonorrhoea treatment is, in addition, obtainable in the type of antibiotic medications. Drinking cranberry juice can help manage the symptoms of the bladder infection. It’s possible for You to take this drug a couple of times a day conditioned upon the severity of your own outbreak. You have to use this drug once per day for a period of one or two weeks, conditioned upon the severity of your own health condition.
Bladder infections could be painful and annoying. Symptoms will be different agreeing with the form of infection. Here’s a list of the sorts of intestinal infections together with their related symptoms. Men and women who keep getting these infections could be at danger of kidney infection. Sometimes, folks are unaware they have caught this infection and this is actually the reason they don’t seek appropriate treatment. This health condition can very quickly be recognized by taking a fast test.
There’s a frequent misconception that one can safely consume over-the-counter painkillers. It’s best to ask your doctor and prevent any unnecessary medication. Always be sure you take the right dose of medicine, not go over the advised limits of alcohol. As said above, over-the-counter painkillers aren’t exactly dangerous for the body. There are specific differences between penicillin and the majority of other drugs. It was discovered that women have a greater mortality rate because of alcoholism than man do.
How exactly to detox yourself from alcohol is most likely a question you’re going to be considering asking if you got a serious alcohol issue. This can knock the flies out, but be sure you’ve removed the fruits, prior to starting spraying. Drink for taste as an alternative to effect. Put on your own wipers and you’ll see the frost clearing up. Often glasses become stained, as a result of oil, grime, dust, sprays and some sticky residue. Though the association is complex, research has demonstrated that numerous genes may cause alcoholism.
We have a tendency to cover the aftermath of the difficulty. We even go the excess length of avoiding her or him. Even during the time they’re not drinking, alcoholics wouldn’t be able to concentrate on the work accessible. Alcoholism also impacts the sufferer psychologically, along with physically. There’s also a solid possibility of alcoholism, affecting different medications. The mixture causes severe dizziness and breathing conditions that may lead to cardiac arrests, if medical attention isn’t received punctually.
In case of the serious bacterial infection, alcohol ought to be avoided because it contains sugar compounds that assist with growth of bacteria. Consuming opioids together with alcohol is a highly lethal combination. This is a very terrible thought to try this, then you ought to be heading to a medical professional for advice. This can make your task of eliminating the marks easy.
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Active – active substance / start: cefixime
Iksim (Iksim Lupin); Pantsef; Supraks; Cefixime; Tsefspan.
Cefixime – an effective and safe oral semisynthetic antibiotic cephalosporin third generation. It is characterized by a wide spectrum of antibacterial activity, high efficacy and safety when used in children from 6 months. It is used for infections of the respiratory tract and ENT – organs, urinary tract, bone, skin, uncomplicated gonorrhea, Gram-negative infections in children .
Active – dejsvie substance:
Cefixime / Cefexime.
Dosage Forms:
The capsules.
granules (powder) for suspension for oral administration.
Cefixime
Properties / Action:
Cefixime – semisynthetic cephalosporin antibiotic for oral use, refers to the III generation cephalosporins, bactericidal effect.
The mechanism of action: inhibits the synthesis of peptidoglycan – a major structural component of the cell wall of bacteria. Cefixime is resistant to beta – lactamases.
Cefixime is characterized by a wide spectrum of antibacterial activity, high efficacy and safety when used in children from 6 months.
Cefixime is active against many Gram-positive and Gram-negative microorganisms: Streptococcus pneumoniae, Streptococcus pyogenes, Streptococcus agalactiae, Haemophilus influenzae, Haemopbilus paramfluenzae, Moraxella catarrhalis (Branhamella), Esherichia coli, Proteus mirabilis, P.vulgaris, Proteus mimbilis, N . gonorrhoeae, Klebsiella pneumoniae, Klebsiella oxytoca, Pasteurella multocida, Providencia species, Salmonella spp, Shigella spp. Citrobacter diversus, Serratia marcescens.
Cefixime was synthesized in 1987 by Fujisava Pharmacevtical Co. Ltd, Osaka, Japan. At present, it has been successfully used in more than 80 countries around the world.
The effectiveness of treatment when taking 1 per day:
(Deparment of Medicine and Clinical Pharmacology, Peterfy Teaching Hospital, HUNGARY)
Pharmacokinetics:
When ingestion bioavailability of cefixime is 45 – 50%, regardless of the meal, and the maximum concentration is reached after 4 hours. However, upon receipt of cefixime with food cefixime maximum concentration reached at 0.8 hour fast.
In blood more than half (65%) binds to albumin. About 50% of the dose is excreted in the urine unchanged within 24 hours, about 10% of the administered dose is excreted in the bile.
The half-life is dose-dependent and ranges from 3 to 4 hours.
For children with impaired renal function (creatinine clearance 20 – 40 ml / min) half-life is increased to 6.4 hours, with the creatinine clearance 5 – 10 ml / min – up to 11.5 hours.
Indications:
Infectious – inflammatory diseases caused by microorganisms sensitive to cefixime:
Dosage and administration:
Inside.
Adults and children over 12 years (or more than 50 kg) – 8 mg / kg / day or 4 mg / kg every 12 hours. The maximum dose of 400 mg / day. In uncomplicated gonorrhea of the urethra and cervix prescribed 400 mg 1 time / day. Babies
5 – 11 years (50 kg or less) – 8 mg / kg 1 time / day or 4 mg / kg every 12 watches – 6 – 10 ml of the suspension per day.
Children aged 2 – 4 years – 5 ml, between the ages of 6 months to 1 year – 2.5 – 4 ml.
In diseases caused by S.pyogenes course of treatment should be not less than 10 days.
When violations of renal function in QA 21 – 60 ml / min or in patients on hemodialysis, the daily dose of cefixime should be reduced by 25%. When QA 20 ml / min or less and in patients undergoing peritoneal dialysis, the daily dose should be reduced by 2 times.
A method for preparing a suspension: to turn the bottle and shake powder. Add 40 ml of cooled boiled water and stir 2 stages after each addition until a homogeneous suspension. Thereafter, the slurry is necessary to stand for 5 minutes to ensure complete dissolution of the powder. Before use, shake well prepared suspension.
Overdose:
Symptoms: increased side effects, especially on the part of the digestive tract.
Treatment: gastric lavage, symptomatic and supportive therapy, which, if necessary, includes the use of antihistamines, corticosteroids, pressor amines, oxygen therapy, transfusion of infusion solutions, IVL. Cefixime is not displayed in large quantities from the circulation by hemo – or peritoneal dialysis.
Contraindications:
Hypersensitivity to cephalosporins.
In children younger than 6 months of treatment efficacy and safety of cefixime is not installed, so the use of cefixime is not recommended.
Use during pregnancy and lactation:
In the period of pregnancy and childbirth cefixime should be used only in cases of extreme necessity, as adequate and well-controlled studies safety of cefixime in these cases has not been (group “bi” in the classification of drugs for pregnant women).
Do not established whether cefixime is allocated to breast milk, so if you must use cefixime during lactation should decide to suspend breast-feeding.
In experimental studies have shown that cefixime did not affect fertility, not mutagenic and carcinogenic effects.
Side effects:
weak.
On the part of the digestive tract. diarrhea, abdominal pain, nausea, vomiting, transient increase in liver enzymes.
Allergic reactions: skin rash, urticaria.
Other: headache, vaginitis, genital candidiasis, transient thrombocytopenia, leukopenia, increased creatinine level.
Special instructions and precautions:
Cefixime prescribed with caution in patients with gastrointestinal disease, particularly colitis. Chronic administration of cefixime may be in breach of the normal flora of the intestine, which can lead to the growth of Clostridia, cause severe diarrhea and pseudomembranous colitis. In addition, the possible emergence of resistance of microorganisms to the drug and the development of superinfection.
If the kidney function in children on hemodialysis daily dose is reduced.
Before therapy is necessary to clarify a history indication hypersensitivity reactions to cephalosporins, penicillins and other drugs.
Drug Interactions:
To date, no clinically significant interactions recorded cefixime with other drugs.
Dispensed by prescription.
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