• Atenolol general information

      • Atenolol (Atenolol): instruction, and the use of a formula

      • Code CAS

      • substance Characteristics Atenolol

      • Pharmacology

      • Application of the substance Atenolol

      • Contraindications

      • Restrictions on the use

      • Application of pregnancy and breastfeeding

      • Side effects of substance Atenolol

      • Interaction

      • Overdose

      • Dosing and Administration

      • Precautions substance Atenolol

Tenormin Atenolol 25 mg, 50 mg, 100 mg
Most popular brand: Tenormin
Active ingredient: Atenolol
Available dosage forms: 25 mg, 50 mg, 100 mg
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Atenolol general information

If so a favorite side impact of atenolol is generally a cough. Terrible stress, on the opposite hand, can force you to be be not would like to get right up in the morning! Non-dihydropyridine calcium channel blockers, like diltiazem or verapamil, might be considered. Cravings are also believed to decrease with using beta-blockers.

I’d begin with digoxin first. Take cyclobenzaprine completely as directed. If you’ren’t having major tachyarrthymias, I’d decrease and stop it. Just Take the missed dose once you remember. Don’t stop taking atenolol without speaking to your doctor. I got a low-cal yogurt or banana for a snack.

The quivering” is almost unbearable and I must uncover what is happening. I really do take immodium, however, after maybe a few episodes. It seems to just occur when I’m sitting. I’ve gone to an eye-ear-throat specialist, Lung specialist, Cardiologist and again, generally, they all appear to think I’m not experiencing anything major, but the actuality remains that I’m still dizzy constantly. Use Amaryl as instructed by your doctor. I don’t drink a whole lot of coffee (three cups a week).

I feel like I’m over medicated. I suspect he means that there’s an occasional beat that’s not perfectly regular. I liked to wait and see the outcomes in the approaching weeks. I can’t locate any information on imdur. Take atenolol completely as directed. Not the same as Imdur that is once each day and usually has to be given 2,3, or 4 times per day.

It’s been 7 months since my very first experience with this and it’s ruining my everyday living. Never any pain. however, it’s sure scarey. Take atenolol just as instructed by your doctor. This will have to be evaluated with a particular catherization and may simply be done by specialized cardiologists. Continue taking atenolol even should you feel well. Suddenly stopping atenolol can cause chest malady, heart attack, or irregular heartbeat.

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Atenolol (Atenolol): instruction, and the use of a formula

Code CAS

substance Characteristics Atenolol

The crystalline powder. Soluble in water (26.5 mg / ml ; at 37 ° C), good ; in 1 M hydrochloric acid solution (300 mg / ml ; at 25 ° C) and poor ; in chloroform (3 mg / ml ; at 25 ° C).

Pharmacology

Mode of action -. Antianginal, hypotensive, antiarrhythmic

Selectively blocking beta 1 – adrenergic receptors, has no membrane stabilizing and intrinsic sympathomimetic activity. Stops central sympathetic impulses, reduces the sensitivity of peripheral tissues to catecholamines, inhibits renin secretion. It slows heart rate at rest and during exercise. The negative chronotropic effect is manifested within 1 h, reaches a maximum after 2 – 4 hours until 24 hours reduces cardiac output, and Sad Dad.. reduces orthostatic tachycardia. The antihypertensive effect lasts for 24 hours, stabilize with regular admission at the end of 2 weeks. It reduces myocardial oxygen demand, but by increasing the tension of the muscle fibers and ventricular end-diastolic pressure in the left ventricle may increase the oxygen inquiry, especially in patients with chronic heart failure. Suppresses sinus node automaticity, prolongs the refractory period, slowing down on the AV node. Increases the survival of patients with myocardial infarction (reduces the frequency of ventricular arrhythmias and angina attacks). Slightly reduces lung function almost does not weaken the bronchodilatory effect of isoproterenol.

Once inside absorbed about 50% of the elderly ; somewhat more. C max is achieved through a 2 – 4 hours, binding to plasma proteins ; 6 – 16%. Poor penetrate the BBB. It passes through the placental barrier and into breast milk. Practically not metabolized by the liver and excreted by the kidneys by glomerular filtration (85%). T 1/2 ; 6 – 7 hours, increases in elderly patients. Renal dysfunction is accompanied by elongation T 1/2 and cumulation: the ability to cumulation shown at Cl creatinine less than 35 mL / min / 1.73 m 2 (dose reduction is necessary).

Prolonged use is accompanied epithelium vacuolation duodenum in dogs (15 mg / kg / day) and the development of degenerative processes in myocardium Male rats (300 mg / kg / day). In experiments on rats (18 months) and mice (24 months) at a dose of 300 mg / kg / day has no carcinogenic action. At doses of 500 and 1500 mg / kg / day (rat) increases the frequency of the adrenal medulla benign tumors of the anterior pituitary adenoma, breast fibroadenomas (females), parafollicular – thyroid carcinoma cell (males). Conducting a cytogenetic test (in vivo) and the Ames test showed no mutagenic properties. The male and female rats doses 100 times higher than MRDCH. an adverse effect on fertility has not been provided. At a dose of 50 mg / kg / day increases the incidence resorption embryo / fetal rats.

Application of the substance Atenolol

Hypertension, angina pectoris, acute myocardial infarction (with stable hemodynamics) Tachycardia:. Sinus, atrial, ventricular, paroxysmal and other beats, atrial flutter and atrial fibrillation, hyperkinetic cardiac syndrome, mitral valve prolapse, neuro-circulatory dystonia of hypertensive type ; Combination Therapy of hypertrophic cardiomyopathy, pheochromocytoma, thyrotoxicosis, essential tremor; migraine (prevention).

Contraindications

Hypersensitivity, sinus bradycardia (heart rate less than 50 beats / min.), Sinoatrial blockade, sick sinus syndrome, AV block II – III degree, hypotension (Sad less than 90 mm Hg..), Acute or chronic heart failure in the stage of decompensation, cardiogenic shock, the peripheral blood circulation, pregnancy, breast-feeding.

Restrictions on the use

Diabetes, hypoglycemia, chronic obstructive pulmonary disease (emphysema, asthma), liver dysfunction and / or kidney disease, myasthenia gravis, depression, psoriasis, pheochromocytoma, metabolic acidosis, children (efficacy and safety are not defined) and old age.

Application of pregnancy and breastfeeding

Category effects on the fetus by FDA ; D.

breast-feeding should be discontinued at the time of treatment.

Side effects of substance Atenolol

From the nervous system and sensory organs: fatigue, weakness, dizziness, headache, drowsiness or insomnia, nightmares, depression, anxiety, confusion, or momentary loss of memory, hallucinations, weakening reaction ability, paresthesia, convulsions; visual disturbances, reduced secretion of saliva and tear fluid, conjunctivitis.

From the cardio – vascular system and blood (blood, hemostasis): bradycardia, heart rate, conduction disturbances infarction, AV block, arrhythmia, weakening of myocardial contractility, heart failure, hypotension, syncope, Raynaud’s phenomenon , vasculitis, chest pain, thrombocytopenia, agranulocytosis.

From the digestive tract: dry mouth, nausea, vomiting, abdominal pain, diarrhea, constipation, abnormal liver function.

From the respiratory system: shortness of breath, laryngitis – and bronchospasm.

Allergic reactions: pruritus, rash, erythema, urticaria, psoriasiform and dystrophic skin changes.

Other: reversible alopecia, rash, cold extremities, myasthenia gravis, weakening of libido, impotence, Peyronie’s disease, changes in the activity of enzymes, bilirubin, withdrawal symptoms, hypothyroid condition, hypoglycemia.

Interaction

anesthetic and antiarrhythmic agents enhance cardiodepressive effects (increased risk of bradycardia, arrhythmia, hypotension, heart failure). Reserpine, methyldopa, clonidine, guanfacine, potentiate cardiac glycosides negative chrono -, Dromo – and bathmotropic, insulin and other antidiabetic agents ; hypoglycemia. NSAIDs. estrogens, sympathomimetics, xanthines weaken hypotensive effect, absorption, increase ; sympatholytic, nitroglycerin, hydralazine and other antihypertensive drugs. antacids ; delay absorption. Cimetidine inhibits metabolism. Antidepolyarizuyuschih prolongs the effect of muscle relaxants, coumarin anticoagulant effect. Three / tetracyclic antidepressants, antipsychotics, sedatives, hypnotics, and alcohol potentiate CNS depression. Incompatible with MAO inhibitors.

Overdose

Symptoms: bradycardia, AV block II – III degree, heart failure, respiratory failure, hypotension, bronchospasm, hypoglycaemia.

Treatment: gastric lavage and the appointment of absorbent; symptomatic therapy: atropine, isoprenaline, ortsiprenalin, cardiac glycosides or glucagon, diuretics, vasopressor agents (dopamine, dobutamine or norepinephrine), selective beta – agonists, glucose solution (w / w), the installation of an artificial pacemaker. Perhaps dialysis.

Dosing and Administration

Inside. The mode set individually. When hypertension ; 25 – 50 mg once daily, if necessary 100 – 200mg 1 – 2 times per day. In CHD. tahisistolicheskoy cardiac arrhythmias ; 1 to 50 mg once a day; if necessary and well tolerated dose may be increased within weeks to 100 – 200 mg / day. In acute myocardial infarction, with stable hemodynamic parameters ; 12 hours ; again 50 mg; below ; 50 mg 2 times a day for 6 – 9 days (under the control of blood pressure EKG glucose..). In the functional disorders of the cardio – vascular system ; 1 to 25 mg once a day. If the kidney function , depending on Cl creatinine: Cl at 15 – 35 mL / min ; 50 mg / day (or 100 mg every other day), less than 15 ml / min ; 50 mg every other day (or one 100 mg 4 times a day); patients on hemodialysis ; 25 – 50 mg / day immediately after dialysis. In elderly patients, an initial single dose is 25 mg (may be increased under the control of blood pressure. Heart rate).

Precautions substance Atenolol

The treatment is carried out at regular medical control. Before starting therapy should be compensated heart failure. During treatment requires monitoring of heart rate. HELL. blood glucose level (possible correction dose antidiabetic agents) and monitoring the appearance of the symptoms of heart failure.

Be wary of during the drivers of vehicles and people skills relate to the high concentration of attention. At the time of treatment is recommended to exclude alcohol intake.

In patients with diabetes mellitus and hyperthyroidism may mask tachycardia caused by hypoglycemia or hyperthyroidism. When pheochromocytoma should be simultaneously used alpha – adrenolytics. Perhaps the increased severity of hypersensitivity reactions and the lack of effect of conventional doses of epinephrine with aggravated allergic history.

In the case of elderly patients increasing bradycardia (less than 50 u. / Min), hypotension (Sad below 100 mm Hg), AV blockade bronchospasm, ventricular arrhythmias, severe liver and kidney function, reduce dose or stop treatment. Discontinue therapy should gradually reducing the dose within 10 – 14 days. Patients with coronary artery disease should be between discontinuation of the drug be monitored carefully. Atenolol should be canceled 48 hours prior to surgery using general anesthesia (chloroform or ether) or select an anesthetic with the least negative inotropic effect.

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