Last Updated on February 19, 2017 by Dr.Derek Fhisher
Most popular brand: Fosamax
Active ingredient: Alendronate
Available dosage forms: 5, 10, 35, 70 mg
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Alendronate general information
Typically, side effects subside as the body adjusts to a brand-new drug. The most frequent side effect of the drug is edema. This could exert a hypertensive result on the heart muscle, which then increases the chance of stroke as well as heart attack. Consequently, such individuals should exercise caution when using this drug. On the opposite hand, fatigue could be experienced by about 4.5% of the individuals who are on this drug, according to clinical studies. Skip and keep together with the next dose the following morning, however, don’t double your dose.
Hearing loss in a single ear can happen in both children and grownups. If this disorder happens in adults, the most crucial symptom is the fact that the person is not able to come after a normal conversation with a single ear, but has no issue with the other. Infections are truly the most common causes of this kind of hearing loss. There are really no major symptoms of the disorder. Passion flower functions as a tranquilizer for those patients afflicted by insomnia, anxiety and restlessness.
Thyroid gland releases thyroxine that aids in proper performance of the metabolism. This spike contributes to excess insulin, as well as a comprehensive disruption in your hormone production. Consequently, causing high blood sugar. Taking lots of bananas while on the potassium-sparing water pills Aldactone (spironolactone) can bring about excessive levels of potassium within the body which can be toxic. If there’s too much calcium in your blood, it may result in a condition called hypercalcemia.
Steer clear of self medication as excess calcium within your body might result in many health complications. Examples include taking particular antacids and also water pills that may lead to nutrient deficiencies causing muscle weakness and other relevant symptoms. Additionally, It has been applied along with vitamin D and calcium for the therapy and avoidance of osteoporosis that’s corticosteroid-related. For strong bones, sufficient quantity of calcium ought to be included within the daily diet.
Osteoporosis can be a medical condition where the bones become weak as a result of loss of essential minerals and general bone density. Perhaps osteoporosis Is the most frequent form of bone disease that could affect both women and men. The status can affect any bone in the entire body, and many bones could be affected at one time. SSHL could be treated with assistance from surgery in the event the bones are damaged because of explosion or alternative trauma. Estrogen is essential for having powerful and dense bones.
Amino acids play a significant part in the appropriate functioning of human body. The perfect work pattern and efficient effect level may be enhanced if prescribed together with vitamin D by the physicians to care for the affected bones. In addition, It can interfere with the entire body’s capacity to absorb particular antibiotics like etc.. Hence It’s recommended to maintain stronger bones with the aid of a healthful diet or physical exercises. Though your specific joint problem may require certain exercises, it really is definite that exercise is crucial in rheumatoid arthritis, of whichever type that you do. There are sure exercises it’s possible to do to make sure your bones will stay healthy.
Many folks aren’t conscious of the many studies that have shown that Acupuncture can work too on pain as prescription medication, but does not have any side consequences. Although it is very effective in curing high blood pressure, like quite a few other medications, it may also generate a few unwanted side effects in certain people. It’s an antihistamine that’s implemented in treating hayfever and other allergies. I recommend that you research any medication your doctor prescribes, and the all-natural alternative remedies. I teach people how to make use of natural, no price tag, non medication methods to lower their blood pressure, reduce menopause symptoms, relieve stress, receive a wonderful night’s sleep, slim down and much more.
It is crucial to understand that taking Fosamax may cause serious adverse effects to your own health. If they want to learn more about Fosamax and the way that it works or potential side effects they might consult with their doctor. Moreover, these tips will not provide all of the information you will need about the drug thus it’s still best to consult your own doctor for your own questions about your own healthcare condition and treatment. Pregnant and breastfeeding women, and those attempting to conceive should talk to their own physician about the use of the hypertension medication. Fosamax also have many side effects which ought to be known. There continue to be other Fosamax side effects that weren’t mentioned within the report.
Edema means retention or accumulation of extra fluid within the tissues. Patients should additionally not lie down for half a hour after swallowing the tablets. Constipation for prolonged time period can cause stomach ulcers, pain and bloating. This is an important symptom of heartburns. There is absolutely no solitary known cause for this particular condition.
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Active – active substance / start: alendronate (alendronate sodium)
alendronate sodium; Alendronate Pliva; Alendronic acid; Lindron; Ostalon; Ostealen; Ostemaks; Strongos; Tevanat; Foroza; Fosamax.
alendronate (alendronate sodium) – bisphosphonate; Corrector metabolism of bone tissue; effective non-hormonal specific inhibitor of osteoclastic bone resorption. It stimulates bone formation and restores a positive balance between bone resorption and bone repair, progressively increases mineral density of bones in the spine, pelvis and other bones of the skeleton, promotes formation of bone tissue with normal histological structure. It is used to treat osteoporosis in postmenopausal women (postmenopausal osteoporosis), and osteoporosis in men (senile osteoporosis) in order to prevent fractures, Paget’s disease (osteitis deformans), hypercalcemia of malignancy.
Active – active substance:
Alendronic acid / sodium Alendronate / Alendronic acid / Alendronate sodium.
Dosage Forms:
Tablets.
alendronate (alendronate sodium)
Properties / Action:
alendronate (alendronate sodium) – Corrector metabolism of bone tissue; effective non-hormonal specific inhibitor of osteoclastic bone resorption.
Alendronic acid is an amino – bisphosphonate. Bisphosphonates are synthetic analogs of pyrophosphate, hydroxyapatite binding, a part of bone tissue. Antirezorbiruyuschego mechanism of action is associated with inhibition of osteoclast function. In preclinical studies it has been shown tropism alendronate the active sites of bone resorption.
Alendronic acid stimulates bone formation and restores a positive balance between bone resorption and bone repair, progressively increases mineral density of bones in the spine, pelvis and other bones of the skeleton, promotes formation of bone tissue with normal histological structure.
Pharmacokinetics:
The bioavailability of alendronate in women when administered on an empty stomach at least 2 hours before lunch standarnogo (in doses ranging from 5 to 70 mg) of 0.64%, from men – 0.6%. Bioavailability is reduced by about 40% when taking alendronate fasting for 1 – 1.5 hours before a standardized breakfast. In general, the effectiveness of alendronate sufficient if taken at least 30 minutes before the first meal. The bioavailability of alendronate negligible as it is received together with a meal or within 2 hours after ingestion. Upon receipt of alendronate with coffee or orange juice reduced bioavailability by approximately 60%. The average distribution volume in a state of equilibrium concentration in humans is about 28 liters. Distributed in the soft tissue, and then rapidly redistributed to bone, where it is binding, or excreted in the urine. Alendronic acid concentration in plasma – less than 5 ng / ml. Plasma protein binding is approximately 78%. Alendronic acid is not metabolized in the body. After a single intravenouslytroduction of alendronate, approximately 50% is excreted in the urine within 72 hours; excretion in the feces is negligible. Renal clearance – 71 ml / min, System – 200 ml / min. After 6 hours after on / in the plasma concentration is reduced more than 95%. In patients with impaired renal function may be expected somewhat larger accumulation of alendronate in bone. Terminal half-life of alendronate in humans than 10 years, which corresponds to the time of removal of the bones of the skeleton.
Indications:
Dosage and administration:
drugs alendronate prescribed only for adults.
Preparations alendronate should be taken at least half an hour before the first food, drink or any drugs, drinking only a full glass of plain water because other drinks (including mineral water), food and medications can reduce the absorption of alendronate. One can not chew the tablet or dissolve in the mouth, because it is at risk of ulceration of the oral cavity and pharynx.
To ensure getting the tablet to the stomach and thus reduce the potential irritant effect of alendronate on the esophagus, it is necessary to take the drug after morning rise from the bed, with a full glass of water. Thus patients after ingestion should not place at least 30 minutes prior to the first day for ingestion. Alendronic acid should not be taken at bedtime or before the morning rise from the bed. Failure to comply with the conditions of the drug may increase the risk of negative effects on the esophagus.
treatment of osteoporosis in postmenopausal women and men: the recommended dosage of 70 mg once per week or 10 mg once a day.
When Paget’s disease – 40 mg / day for 6 months.
alendronate dosage adjustments are not required or for elderly patients or for patients with mild to moderate renal insufficiency (creatinine clearance 35 to 60 mL / min). In the absence of data alendronate is not recommended for use in patients with more severe renal insufficiency (creatinine clearance = 1%:
alendronate 70 mg / once a week.
alendronate 10 mg / once a day.
Special instructions and precautions:
Alendronic acid, like other bisphosphonates, may cause local irritation of the upper gastro – intestinal tract. In some cases, side effects were pronounced, and required hospitalization. In this connection it is necessary to examine with special attention to any signs or symptoms suggestive of the possibility of reaction on the part of the esophagus. Patients should be informed about the need to stop taking alendronate and seek medical help if symptoms of esophageal disease: difficulty or pain when swallowing (dysphagia), chest pain, new or worsening heartburn. The risk of serious side effects on the esophagus, is likely to be higher in patients who lie down after taking alendronic acid and / or are taking medication is not washing it down with full glass of water, and / or continue taking the drug after the development of symptoms characteristic of esophageal irritation. Thus, it is a very important clarification of the rights of patients receiving alendronate and draw attention to the need for their strict compliance. In connection with a possible irritant effect of alendronate on the upper gastrointestinal mucosa – intestinal tract, caution must be exercised in the appointment of alendronate patients with acute upper gastrointestinal diseases – intestinal tract, such as dysphagia, oesophageal disease, gastritis, duodenitis or ulcer.
The patient should be informed that if you accidentally missed doses at a dosage of 1 time per week (70 mg), should take 1 tablet in the morning the next day. Do not take 2 tablets in one day, but in the future we need to continue to take 1 tablet on the day of the week, which has been selected for admission to the start of treatment.
Combined use of alendronate with estrogen drugs (but not simultaneous reception) is not accompanied by a change in their actions and the development of side effects.
It is necessary to take into account other causes of osteoporosis not associated with estrogen deficiency and aging. It does not investigate the effect of alendronate for the treatment of osteoporosis caused by taking corticosteroids.
In the presence of hypocalcemia is necessary to conduct its correction before treatment alendronate. Patients with other disorders of mineral metabolism (such as a deficiency of vitamin D) should receive the full appropriate treatment. Due to the fact that Alendronic acid increases mineral content in bones, may have a slight asymptomatic reduction of calcium and phosphate in the serum (including patients receiving corticosteroids, whose calcium absorption can be lowered). In this case, to ensure an adequate supply of vitamin D and calcium with the food or in the form of drugs.
In clinical studies, there was no age-related differences in the efficacy and safety of alendronic acid.
alendronate is not administered to patients with rare hereditary diseases – galactose intolerance, lactase deficiency or glucose – galactose malabsorption.
Effects on ability to drive and use other mechanisms:
Alendronic acid does not affect the ability to drive and operate potentially dangerous machinery.
Drug Interactions:
Special studies alendronate interactions with other drugs have not been conducted.
interval between reception of alendronic acid and others. medicaments should be at least 30 minutes.
calcium preparations, antacids, and some other means taken by mouth, can affect the absorption of alendronate if taken at one and the same time.
NSAIDs (indomethacin. Ibuprofen. diclofenac and others.) increase gastrotoxicity alendronate.
ranitidine increases the bioavailability of 2 times (the clinical significance is not defined).
Reception and prednisolone into healthy volunteers is not accompanied by clinically significant changes in the bioavailability of alendronate.
The combined use gormonzameschayuschey therapy (estrogen / progestin) and alendronate has been studied in two clinical trials lasting 1 or 2 years with the participation of postmenopausal women with osteoporosis. Using this combination resulted in a greater increase in bone mass and a significant reduction of bone resorption compared to the separate use of the first or second treatment. In these studies the safety profile and tolerability of combination therapy correspond to those in the application of each of these treatments on their own.
Other drug interactions with clinical significance, are not supposed to.
Storage:
List B. Store at room temperature (15 – 25 ° C) in a dry, protected from light, out of reach of children.
The expiration date on the package. Do not use beyond the expiration date.
Terms of pharmacy holiday – by prescription.
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