Last Updated on February 19, 2017 by Dr.Derek Fhisher
Most popular brand: Lozol
Active ingredient: Indapamide
Available dosage forms: 1,5, 2,5 mg
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Indapamide general information
The actual fact is that you continue to take normal baths during your pregnancy, but it really is very important to take selected precautions as doctors suggest. If you’re taking any contraceptives to prevent unwanted pregnancy, ask your gynecologist to check if they’re interfering with the regularity of your own menstrual cycle. A phase for example pregnancy requires a female to be well-hydrated, with the purpose to avert some of the other pregnancy issues. In the long run, when the pregnancy is confirmed, the woman shouldn’t wait any further and immediately begin taking the crucial care and precautions for a secure pregnancy.
Pain connected with sciatica is usually felt in a single side of the human body. The pain brought on by sciatica may also radiate to the legs. While pregnant, many women suffer with tension and anxiety, which might produce symptoms, including difficulty in breathing, back malady, shoulder malady, and sometimes even rib pain. Usually, these cramps will come and go by themselves and you can employ certain home treatments prefer to alleviate the pain from cramping.
You’ll forget each of the pain which you have suffered in your pregnancy, after getting to see the sight of your own baby! What’s within the urine that confirms you’re pregnant or not. On the opposite hand, oftentimes owners don’t know of their dog’s heat cycles and on occasion the female dog mates using a male dog less the knowledge of her owner.
A lot of women when pregnant, occasionally drink chamomile tea to acquire relief from nausea. The real key to steer clear of pregnancy problems caused by chamomile tea is moderate intake. Chamomile tea and pregnancy aren’t enemies of one another, if and only if the beverage isn’t abused. Consequently, a cautious approach is recommended in regards to drinking chamomile tea while pregnant.
When pregnant, a woman’s breasts upsurge in size on account of the hormonal changes (upsurge in the amount of estrogen and progesterone) that take place in the entire body. In the first stages of pregnancy, something similar happens, except the endometrium thickens more than it usually does. Actually, it is regarded among the first signs of pregnancy. The chance of pregnancy would be slim however it’s still there.
It sometimes leads to the stomach acids to pass back in the throat, leading to heartburn and gas. In case the vomiting is very forceful and for quite a while, it can rupture the esophagus (the swallowing tube), which can lead to stains of blood whilst vomiting. The truth is that saffron is beneficial in stimulating suitable digestion when pregnant. Changes in taste and having an urge to eat foods which you usually don’t like, might be an indication of pregnancy.
Older patients are somewhat more possible to suffer from the side results and might require close observation. During this waiting period, you might experience particular symptoms that may look identical to PMS. In the event the pain is very severe, then your personal doctor may recommend the utilization of analgesics. On the opposite hand, medicinal herbs prescribed for healing various health issues, are highly concentrated.
Rib pain when pregnant is really nothing to get worried about. Rib pain, notably in the previous trimester, is experienced by a lot of women, too. Wearing ill-fitting clothes have turned into the most frequent source of navel pain. Using a tiny pillow to make the perfect arch supporting the back will minimize pain.
indapamide – instructions for use, real counterparts and release form (tablets 2.5 mg and 1.5 mg retard, CF and Stade capsules 2.5 mg Verte) diuretic medications for the treatment of hypertension in adults and children pregnancy
In this article, you can read the instructions for use of the drug indapamide. Presents reviews of visitors – users of the drug, as well as the opinion of medical specialists on the use of the diuretic indapamide in their practice. Most requested actively add their own reviews of the preparation: helped or did not help to get rid of the medicine from the disease, which were observed complications and side effects may not be claimed by the manufacturer in the summary. Analogs of indapamide in the presence of the available structural analogues. Use for the treatment of hypertension in adults and children, as well as during pregnancy and lactation. How long you need to take the drug.
indapamide – antihypertensives, thiazide diuretic with moderate in intensity and prolonged in duration, benzamide derivatives. Salureticheskim has a moderate and diuretic effects that are associated with the blockade of reabsorption of sodium, chlorine, hydrogen, and to a lesser extent potassium ions in cortical proximal tubule, and distal tubule of the nephron segment. Vasodilating effect and a decrease in total peripheral vascular resistance are based on the following mechanisms: decrease vascular reactivity to norepinephrine and angiotensin 2; an increase in the synthesis of prostaglandins that have vasodilating activity; inhibition of calcium current in vascular smooth muscle wall.
Reduces the tone of smooth muscles of arteries, reduces the total peripheral vascular resistance. It helps to reduce hypertrophy of the left ventricle of the heart. At therapeutic doses it has no effect on the lipid and carbohydrate metabolism (including patients with concomitant diabetes).
The antihypertensive effect develops in the late first / early second week of taking the drug at a constant and lasts for 24 hours on a background of a single dose.
Once inside quickly and completely absorbed from the gastrointestinal tract; bioavailability – high (93%). Food intake slows down the absorption rate, but does not affect the amount of the absorbed compound. It has a high volume of distribution, passes through the blood-tissue barriers (including placental) passes into breast milk. It is metabolized in the liver. The kidneys remove 60 – 80% in the form of metabolites (unchanged output of about 5%), through the intestines – 20%. In patients with renal insufficiency The pharmacokinetics does not change. Not accumulates.
The tablets, film-coated 2.5 mg.
film-coated tablets 2.5 mg Stada.
The modified-release tablets, coated tablets 1.5 mg indapamide MW.
The long-acting tablets, coated tablets 1.5 mg retard.
2.5 mg Capsules Verte.
Instructions for use and dosing regimen
The tablets are taken orally without chewing. The daily dose – 1 tablet (2.5 mg) per day (in the morning). If after 4 – 8 weeks of treatment is not achieved the desired therapeutic effect, the dose of the drug is not recommended to raise (increase the risk of side effects without increasing antiginertenzivnogo effect). Instead, the drug regimen is recommended to include another antihypertensive drug, which is not a diuretic.
In cases where treatment is necessary to start from receiving the two drugs, indapamide dose is equal to 2.5 mg once daily in the morning.
Inside, without chewing, drinking plenty of fluids, regardless of the meal, preferably in the morning hours at a dose of 1.5 mg (1 tablet) per day.
If after 4 – 8 weeks of treatment is not achieved the desired therapeutic effect, the dose of the drug is not recommended to increase (increased risk of side effects without increasing the antihypertensive effect). Instead, the drug regimen is recommended to include another antihypertensive drug, which is not a diuretic. In cases where treatment is necessary to start from receiving the two drugs, the dose indapamide retard remains at 1.5 mg once daily in the morning.
In elderly patients should be monitored plasma concentration of creatinine according to the age, weight and gender, the drug can be used in elderly patients with normal or mildly impaired renal function.
- nausea, vomiting;
- dry mouth;
- general weakness;
- muscle spasm;
- blurred vision;
- orthostatic hypotension;
- hemorrhagic vasculitis;
- hyperglycemia, hypokalemia, hyposalemia, hyponatremia, hypercalcemia;
- flu-like symptoms;
- chest pain;
- back pain;
- reduced potency;
- weight loss;
- tingling in the extremities.
- severe hepatic (including with encephalopathy) and / or renal failure;
- the age of 18 years (effectiveness and safety have installed);
- simultaneous reception of drugs prolonging the interval QT;
- hypersensitivity to the drug and other sulfonamide derivatives.
Application of pregnancy and breastfeeding
is contraindicated during pregnancy and lactation.
In patients taking cardiac glycosides, laxatives, amid hyperaldosteronism, as well as in the elderly shows a regular monitoring of the content of potassium ions and creatinine.
While taking indapamide should systematically monitor the concentration of potassium ions, sodium, magnesium in blood plasma (may develop electrolyte disturbances), pH, concentration of glucose, uric acid and residual nitrogen.
The most careful control shown in patients with liver cirrhosis (especially with edema or ascites – the risk of metabolic alkalosis, increase the expression of hepatic encephalopathy), ischemic heart disease, congestive heart failure, as well as in the elderly. For high risk include patients with an increased QT interval on the electrocardiogram (congenital or develop on the background of – a pathological process).
The first measurement of the concentration of potassium in the blood should be held during the first week of treatment.
For the diuretic and antihypertensive effect of the drug is necessary for life, in the absence of side effects and contraindications to the reception.
hypercalcemia in patients receiving indapamide may be due to previously undiagnosed hyperparathyroidism.
In patients with diabetes is extremely important to control blood glucose levels, especially in the presence gipokapiemii.
Considerable dehydration may lead to acute renal failure (decreased glomerular filtration). Patients need to compensate for the loss of water and at the beginning of treatment carefully monitor renal function.
Indapamide may give a positive result in the doping – control.
Patients with hypertension and shponatriemiey (due to diuretics) must be 3 days before you start taking ACE inhibitors stop taking diuretics (if necessary diuretic may be resumed later), or they are assigned initial low doses of ACE inhibitors.
sulfonamide derivative can exacerbate during systemic lupus erythematosus (you must keep in mind the appointment of indapamide).
Effects on ability to drive vehicles and management mechanisms
During the period of treatment must be careful when driving and occupation of other potentially hazardous activities that require high concentration and psychomotor speed reactions.
Saluretics, cardiac glycosides, gluco – and mineralocorticoids, tetrakozaktid, amphotericin B (IV), laxatives increase the risk of hypokalemia.
When concomitantly with cardiac glycosides increases the likelihood of digitalis intoxication; with drugs Ca2 – hypercalcemia; metformin – possibly worsening lactic acidosis.
Increasing the concentration of lithium ions in the blood plasma (reduced urine excretion), lithium has nephrotoxic effects.
astemizole, erythromycin vnturivenno, pentamidine, sultopride, terfenadine, vincamine, antiarrhythmics 1a class (quinidine, disopyramide) and class 3 (amiodarone, bretilium, sotalol) may lead to arrhythmia development of the type of “torsades de pointes”.
Non-steroidal anti-inflammatory drugs, glucocorticosteroid agents tetrakozaktid, sympathomimetic reduce the hypotensive effect of baclofen – reinforces.
The combination with potassium-sparing diuretics may be effective in a certain category of patients, however, this is not completely ruled out the possibility of hypo – or hyperkalemia, especially in patients with diabetes and renal insufficiency.
ACE inhibitors increase the risk of arterial gipotenzni and / or acute renal failure (especially when existing renal artery stenosis).
increases the risk of renal dysfunction when using iodine-containing contrast agents in high doses (dehydration). Before use of iodine-containing contrast media to patients need to restore lost fluids.
Imipraminovye (tricyclic) antidepressants and drugs antipsihotichsskis enhance the hypotensive effect and increase the risk of orthostatic gipotenzni.
Cyclosporin increases the risk of hypercreatininemia.
Reduces the effect of indirect anticoagulants (coumarin derivatives or indandiona) due to increased concentration of clotting factors by reducing blood volume and increase their production by the liver (may require dose adjustment).
Strengthens blockade of neuro – muscular transmission, developing under the influence of non-depolarizing miorelaksaktov.
Analogues drug indapamide
The structural analogs of active material:
- Akripamid retard;
- Akuter – Sanovel;
- Arifon retard;
- Vero – indapamide;
- indapamide MB Stada;
- indapamide retard;
- Stada indapamide;
- indapamide – OBL;
- indapamide – Verte;
- indapamide – Teva;
- Ionic retard;
- Long Ipres;
- Lorvas CP;
- Ravel SR;
- SR – Indamed;
In the absence of drug analogs of active material, it is possible to follow the links below on the disease, which makes it an appropriate drug and see the existing analogues for therapeutic impact.