Last Updated on February 19, 2017 by Dr.Derek Fhisher
Most popular brand: Prandin
Active ingredient: Repaglinide
Available dosage forms: 0,5, 1, 2 mg
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Repaglinide general information
Repaglinide should be shunned in patients using a history. The procedure can be done in a physician’s office and takes about ten minutes. The patient must be educated in the best way to use them by a seasoned sleep technician. There’s also growing evidence of the connection between obstructive sleep apnea as well as heart disease.
Many experts think that people discover insomnia, and will learn to sleep better. Simply attempting to treat snoring won’t treat sleep apnea. The following simple sleep tips may make a tremendous difference.
It’s not clear if there’s an independent relationship between both conditions or whether obesity is the sole common factor. You have to discuss the advantages and risks of using Repaglinide while you’re pregnant. Various medications are on tap to treat sleep troubles. People may not even know they got the condition.
Currently, as a result of undetected blood glucose problems, a lot of people never go into fat metabolism during the night whatsoever, instead trying to burn sugar and carbs throughout the night since they did during the day. The 2nd most common source of insomnia is really a silent blood glucose issue that affects one third of Americans. Nicotine is just a stimulant, which speeds pulse and thinking. In certain situations, scientists have found sleep-restricted subjects didn’t have an elevated appetite, yet they still gained weight.
Sleep apnea is related to a greater incidence of several health conditions, besides heart and circulation. The chance of obesity is, in addition, increased by sleep deprivation. There’s an association between the daily consumption of caffeine, sleep issues and daytime sleepiness. Poor sleep is, in addition, related to increases within the secretion of insulin following a meal.
If sleep apnea isn’t obvious after a concrete examination and history, the physician will have to rule out every other difficulties. In some instances, sleep debt results from insomnia or another underlying conditions which will require medical attention. We don’t yet know whether adjusting one’s sleep can lessen the risk of eventually creating a disease or reduce the severity of a continuous disease. Dearth of sleep has been demonstrated to increase blood sugar and the danger of diabetes. Ask your wellbeing care provider if Repaglinide may interact with several other medicines which you take.
There’s a huge difference between the quantity of sleep you may get by on along with the amount you should function optimally. It’s likewise still extremely efficient when compared with monophasic with only 3-4 hours of sleep daily. Melatonin does have negative effects. Avoid naps over the course of the day.
Please consider the surroundings before printing. This might not be considered a comprehensive list of all interactions which may occur. Keep the nap to about thirty minutes and attempt to do it at an identical time every day before 3pm. Additionally, It suggests that a household camping trip before school starts might become a healthful family experience.
Sleep experts say dimming the lights through the night and receiving a lot of daylight within the morning can provide help. Sleep caught between soundings of such alarm is simply not high-quality sleep. CPAP works well but it may take a while to get used to, particularly for the very first few nights. A normal meal schedule can also assist you get a great night’s sleep.
Many uberman-users report increased capacity to lucid dream too. Scientists don’t fully understand every one of these interactions. Continue reading to pick up the facts concerning this troubling, little-known sleep issue. There’s a superb grounds for that.
The mode set individually, selecting the dose to optimize blood glucose.
The recommended starting dose is 500 micrograms. Increasing the dose should be carried out not earlier than 1 – 2 weeks of continuous use, depending on the laboratory parameters of carbohydrate metabolism.
The maximum doses: one-time – 4 mg daily – 16 mg.
After the application of other hypoglycemic drug the recommended initial dose is 1 mg.
Take before each main meal. The best time of the drug – 15 minutes before a meal, but may be taken 30 minutes before a meal or immediately before a meal.
From a metabolism: effect on carbohydrate metabolism – hypoglycemic state (pallor, sweating, palpitations, sleep disorders, tremor); fluctuations in blood glucose levels can cause temporary disturbances in visual acuity, especially at the beginning of treatment (observed in a small number of patients and did not require discontinuation of the drug).
From the digestive system: abdominal pain, diarrhea, nausea, vomiting, constipation; in some cases – increase in liver enzymes.
Allergic reactions: itching, erythema, urticaria.
Type 1 diabetes (insulin-dependent) diabetic ketoacidosis (including with coma), severe renal dysfunction, severe liver dysfunction, concomitant treatment with drugs that inhibit or induce of CYP3A4, pregnancy (incl . planned), lactation, hypersensitivity to repaglinide.
Pregnancy and breastfeeding
Application of pregnancy and lactation is contraindicated.
The experimental research found that no teratogenic effects; however, when used in high doses in rats in late pregnancy there was embryotoxicity, impaired development of the limbs of the fetus. Repaglinide is excreted in breast milk.
Application for violations of liver function
is contraindicated in severe hepatic dysfunction.
Application for violations of renal function
is contraindicated in severe renal impairment.
When liver or kidney disease, major surgery, recent myocardial disease or infection may decrease the effectiveness of repaglinide.
To apply caution in patients with kidney disease.
In debilitated patients, or in low-power repaglinide patients should be taken at the minimum initial and maintenance doses. To prevent hypoglycemic reactions in these patients the dose should be chosen with care.
Emerging hypoglycemic state reactions are usually of moderate severity and easily stoped taking carbohydrates. In severe conditions may need to be / in the glucose. The likelihood of such reactions depends on the dose, dietary habits, intensity of physical activity, stress.
Keep in mind that beta – blockers may mask the symptoms of hypoglycemia.
During treatment, patients should abstain from alcohol, because Ethanol can enhance and prolong the hypoglycaemic effect of repaglinide.
Effects on ability to drive vehicles and management mechanisms
On the background of repaglinide should assess the advisability of driving or doing other potentially hazardous activities.
Increased hypoglycemic effect of repaglinide is possible with the simultaneous use of MAO inhibitors, non-selective beta – blockers, ACE inhibitors, salicylates, NSAIDs, octreotide, anabolic steroids, ethanol.
The decrease hypoglycemic effect of repaglinide possible, while the use of hormonal contraceptives for oral administration of thiazide diuretics, corticosteroids, danazol, thyroid hormones, sympathomimetics (with the appointment or termination of these drugs must be carefully monitor the status of carbohydrate metabolism).
With the simultaneous use of repaglinide with drugs, which are mainly excreted in the bile, it should consider the possibility of a potential interaction between them.
In this regard, available data on the metabolism of repaglinide of CYP3A4 should take into account possible interactions with inhibitors of CYP3A4 (ketoconazole, itraconazole, erythromycin, fluconazole, mibefradil), leading to increased levels of repaglinide plasma. Inducers of CYP3A4 (including rifampicin, phenytoin), can reduce the plasma concentration of repaglinide. Since the degree of induction has not been established at the same time the use of repaglinide is contraindicated with these drugs.
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