Last Updated on February 19, 2017 by Dr.Derek Fhisher
Most popular brand: Rulide
Active ingredient: Roxithromycin
Available dosage forms: 150 mg
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Roxithromycin general information
The following time you went using a cough-its another antibiotic. For example, roxithromycin has stronger anti-inflammatory properties when compared with clarithromycin and azithromycin. They may likewise be given as well as other antibiotics. Macrolides are frequently recommended in position of penicillin, once the patient is allergic to penicillin.
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The drug “Roxithromycin”: instructions for use, description, analogs, reviews
November 2, 2015
In some patients the dose administered « Roxithromycin »? Instructions for use of tablets will be described hereinafter. Also from the article you will learn how much is this medication if he has analogues, what side effects and contraindications.
The composition, description, form of the drug
Tablets « Roxithromycin » film-coated, are white and round and biconvex shape engraved « 164 ».
The active ingredient of this medication is roxithromycin. In addition, the drug and includes auxiliary components such as giproloza, povidone K30, poloxamer, magnesium stearate, colloidal silicon dioxide, talc and corn starch.
With regard to film coating, it contains hypromellose, dextrose, propylene glycol and titanium dioxide.
The sale of drugs supplied in blister packs and cardboard respectively.
The pharmacological characteristics of antibiotic pills
What is the effect on the body medicine « Roxithromycin »? Instructions for use states that it is a semi-synthetic antibiotic belonging to the group of macrolides, which possesses a wide spectrum of antibiotic activity.
The drug has a bacteriostatic effect. It binds to the 50S ribosomal subunit, slow ribosome protein synthesis, inhibits transpeptidation reaction and translocation, as well as processes of formation of bonds between the peptide chain and amino acids. Such exposure promotes inhibition of growth and reproduction of bacteria.
Antibiotics « Roxithromycin » It penetrates well and quickly into the cells, which ensures its high efficacy against intracellular pathogens.
The pharmacokinetics of the drug
Where does the absorption of the drug « Roxithromycin »? Guest experts report that after oral administration of the medication is absorbed from the gastrointestinal tract.
The tablets are stable in the acidic environment of the stomach. Food, drinking through a & frac14; hours after the medicament has no effect on its absorption.
After receiving the drug its maximum concentration is reached after one and a half – two hours.
The use of the drug in 13 hours with an interval ensures that the required concentrations of drug in the blood throughout the day.
The connection to plasma proteins is 95.5%. At the same time the drug gets into the lungs, prostate and palatine tonsils. Also it is found in cells (macrophages) and various body fluids.
« Roxithromycin », whose price is listed below, practically does not penetrate the blood-brain barrier and is excreted in breast milk only in very small amounts. Despite this, take this medicine in such periods is prohibited.
The drug is partially metabolized in the liver. Its largest part (around 50%) is excreted unchanged in the intestines, as well as through the kidneys (12%) and light (about 15%).
The half-life of the active substance after a single dose is approximately 13 hours.
the maximum concentration and half-life of the drug is increased When the poor performance of the liver.
Indications for use
For what purposes prescribed pills « Roxithromycin »? Instructions for use states that it is a means to effectively treat infections that are caused by susceptible pathogens to the active substance.
For adults medication prescribed for people:
- tonsillitis, pharyngitis, acute sinusitis;
- soft tissue infections and skin;
- pneumonia, bronchitis;
- urinary tract infections;
- infections in dentistry (teeth and oral cavity).
« Roxithromycin » Children appoint at:
Contraindications to the use of antibiotic agents
In some cases, the patient does not prescribe the drug « Roxithromycin »? Instructions for use according to the following prohibitions:
- Increased patient sensitivity to roxithromycin or macrolides in general, as well as other drug substances;
- during pregnancy;
- simultaneous reception « cisapride », « terfenadine », « pimozide » and « astemizole »;
- body weight less than 40 kg;
- during breastfeeding;
- integrated use of vasoconstrictor ergot alkaloids (ergotamine, dihydroergotamine and);
- the age of 12 years.
Careful assignment tablets
The drug is « Roxithromycin », which analogues will be presented below, with the caution prescribed to people with hepatic or renal insufficiency, elderly patients, and patients with conditions that contribute to heart rhythm disorders, and congenital prolongation of the QT period
drug dosage to adults and children
The tablets prescribed inside before a meal. For adults and children older than 12 years a standard dosage is 150 mg twice a day at intervals of 13 hours or 300 mg dose (for adults).
In elderly people daily and a single dose of the drug does not change. Patients with renal insufficiency drug administered in a dose of 150 mg twice a day.
Patients with liver failure reduce the dosage by half (to 150 mg once a day).
The duration of treatment of adults and children
How long will take the drug « Roxithromycin »? The duration of treatment depends on the indication, and the microorganism that caused the infection and severity of disease.
In adults, the standard rate may take about 5 – 10 days. For infections that were caused by beta – hemolytic streptococcus, the therapy should last at least 10 days.
With regard to children, the duration of the course they also amounts to 5 – 10 days.
When higher doses of medication the patient may increase dose-related side effects. As the treatment of such conditions using symptomatic treatment and gastric lavage.
While taking the drug under review, the patient may show the following side effects:
- nausea, abdominal pain, vomiting, diarrhea, pseudomembranous colitis, pancreatitis;
- increased activity of hepatic transaminases, acute hepatocellular or cholestatic hepatitis;
- paraesthesia, dizziness, change in taste, headache, disturbances of smell, hearing loss is temporary, hallucinations, vertigo, Gipoakuzija;
- reddening, rash, purpura;
- angioedema, bronchospasm, urticaria, eosinophilia;
- anaphylactic shock, erythema multiforme;
- superinfection, candidiasis.
People with liver failure medication appointed with extreme caution.
With the development of allergic reactions and superinfection drug should be withdrawn and appropriate therapy to the patient.
If taking medication, as well as two – three weeks after the treatment, the patient may develop diarrhea, pseudomembranous colitis caused by.
The drug is « Roxithromycin » and alcohol is prohibited to combine.
Considered the medication is not administered with drugs that contain ergotamine, dihydroergotamine, or, as it may cause arterial spasm.
Do not take « Roxithromycin » to « terfenadine » of – the increased risk of complications from cardio – vascular system.
At the same time taking this drug with the « digoxin » may increase its absorption, which will lead to the development of glycoside intoxication.
The combination of « Cyclosporine » or « Theophylline » to « roxithromycin » can cause increased plasma concentrations of the latter.
The most popular analog of « roxithromycin » It is « Erythromycin ». Instruction states that the drug is an antibiotic also.
So which of these tools better? Compared with the « erythromycin » « Roxithromycin » It has more improved pharmacokinetic properties. Following oral administration, it is quite rapidly absorbed from the gastrointestinal tract.
Having a more developed bioavailability, which is weakly dependent on the food intake, the drug is found in the blood already after a & frac14; hours.
It should also be said that the drug is « Roxithromycin » tangible forms a reliable concentrations and not only in human body fluids and tissues, but in the serum.
Thus, it is safe to note that the first drug of the second bit worse. « Erythromycin », which instructions are also enclosed in a cardboard box, is obsolete antibiotic.
In addition to these funds, the drug « Roxithromycin » can be replaced, and such drugs as « Brilid », « Esparoksi », « Vero – Roxithromycin », « Elroks », « Ksitrotsin », « Rusbrikar », « Remora », « Rulitsin », & laquo ; Rokseptin “,” Rulid “,” RoksiGEKSAL “,” Romik, “” peroxide “,” Roksolit “,” Roksilor “” Roxithromycin DS “,” Roksimizan ».
How much is antibiotic « Roxithromycin »? The price of this drug is quite high. Buy it in pharmacies is possible for 550 – 600 USD.
Testimonials about the medicine
Antibiotics « Roxithromycin » – A pretty popular drug among patients. So there are quite a number of comments about this tool. Most people reported that this medication manifests itself as a very effective antibiotic medication. In combination with other medications he is fighting various infections of the lower and upper respiratory tract (tonsillitis, pharyngitis, acute sinusitis), and urinary tract, soft tissues and skin.
In addition to the positive feedback from there, and the negative of the tool. Most often last associated with side effects that occur in patients receiving the drug under consideration. Some patients complain of nausea, severe diarrhea, headaches, vomiting, rash and exacerbation of pancreatitis.
When you see these symptoms, doctors recommend to refuse to accept the tablets and see a doctor, who is obliged to advise a safer medication.
It should also be noted that there are a lot of reviews that the drug has an inflated cost. Patients claim that the analogues of this tool are much cheaper and at the same time did not concede his efficiency.