Last Updated on February 19, 2017 by Dr.Derek Fhisher

Luvox Fluvoxamine 50, 100 mg
Most popular brand: Luvox
Active ingredient: Fluvoxamine
Available dosage forms: 50, 100 mg
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Fluvoxamine general information

Fluvoxamine is wholly absorbed following oral administration. Fluvoxamine shouldn’t be used in conjunction with MAOIs (see also contraindications). There is absolutely no particular antidote to fluvoxamine. Thus far, there are really no known problems related to long-term use of fluvoxamine.

Fluvoxamine is mainly taken 2 times daily with or without food. Fluvoxamine undergoes extensive metabolism within the liver. The other metabolites aren’t anticipated to be pharmacologically active. There are not any particular laboratory tests recommended.

It might be more complicated to stop taking Prozac if it’s been taken over the course of many decades, rather than several weeks or months. Although fluvoxamine is typically used for OCD, it is likewise qualified for depression. Your own doctor may would like you to gradually lessen the amount you’re taking before stopping it completely. Fluvoxamine and tizanidine shouldn’t be used together.

Luvox Cr can be a rather hard drug to quit taking. Fluvoxamine is largely prescribed for adults. Fluvoxamine treatment was associated with various instances of priapism. Call your physician for medical advice regarding side effects. When you have taken Luvox and been via the withdrawal procedure, don’t hesitate to share your experience within the comments section below.

People living with MDD wishing to turn into pregnant face important decisions. Families and caregivers of patients ought to be advised to locate the emergence of said symptoms on a daily basis, since changes might be abrupt. While there aren’t any systematic studies to answer the inquiry of how long to carry on fluvoxamine cure, OCD is just a chronic condition and it’s reasonable to think about continuation beyond 10 weeks in responding patients. In such scenarios, somebody may wind up deciding it would be better to discontinue treatment. Safe use of fluvoxamine when pregnant and lactation hasn’t been established. Fluvoxamine is located in breast milk and must be used with caution in mothers that are breast-feeding.

You might need urgent medical care. Don’t take different medicines unless they’ve been discussed with your physician. In addition, your health care professional might be able to let you know about methods to stop or reduce a number of these side results. Some side effects may happen that usually don’t need medical attention. Some medicines aren’t suitable for those who have certain circumstances, and at times a medicine may just be used if extra care is taken. These medications aren’t suggested for women who are or wish to develop into pregnant.

Fluvoxamine is an antidepressant medication that is employed within the brain. A particular treatment to reverse the repercussions of fluvoxamine will not exist. In patients who develop these symptoms, raising the dose could possibly be detrimental and it might be required to review the utilization of fluvoxamine. Fluvoxamine may potentiate the repercussions of alcohol and boost the degree of psychomotor impairment. Fluvoxamine can also be used in treating obsessive compulsive disorder. Consequently, it is strongly recommended that fluvoxamine not be utilized in conjunction with pimozide.

If you’re pregnant, please discuss the risks and advantages of antidepressant use by means of your healthcare provider. Only your healthcare provider can determine the duration of treatment that’s appropriate for you. Fluvoxamine administration needs to be discontinued in such instances.

Your condition isn’t going to improve any faster, along with your risk of side effects increase. This will definitely allow for developments in the dose and also to help decrease any side outcomes. This medication operates by helping reestablish the balance of the certain all-natural substance (serotonin) in the mind. In this means, fluvoxamine helps relieve depression.

FLUVOXAMINE (fluvoxamine)

Set individually. At the beginning of treatment a daily dosage of 50 – 100 mg (advised to take at night). In case of insufficient effectiveness of the daily dose can be increased to 150 – 200 mg. The maximum daily dose – 300 mg. If a daily dose of 100 mg, it should be divided into 2 – 3 doses.

In accordance with the official recommendations of the WHO antidepressant medication should be continued at least for 6 months after treatment of a depressive episode.

From the digestive system: often – nausea, sometimes accompanied by vomiting (usually disappears within the first 2 weeks of treatment); possible – constipation, anorexia, dyspepsia, diarrhea, discomfort in the epigastric region, dry mouth, discomfort; rare – increase in liver enzymes, predominantly in elderly patients – transient hyponatremia (in some cases due to the syndrome of inappropriate secretion of ADH, disappearing after the abolition of fluvoxamine).

CNS: are possible drowsiness, dizziness, headache, insomnia, anxiety, agitation, anxiety, tremors, discomfort, asthenia; after abrupt withdrawal of fluvoxamine were observed in rare cases headache, nausea, dizziness, feeling of fear.

Cardio – vascular system: , a slight decrease in heart rate (2 – 6 beats / min.), Palpitations, tachycardia.

Other: possibly increased sweating, change in body weight.

Some of the side effects listed above may be symptoms of depression and are not due to the action of fluvoxamine.


Severe hepatic dysfunction, the simultaneous use of MAO inhibitors, children up to 8 years, hypersensitivity to fluvoxamine.

Pregnancy and breastfeeding

If necessary, use of fluvoxamine during pregnancy should assess the potential benefits of therapy for the mother and the potential risk to the fetus.

fluvoxamine should not be used during lactation, because this active substance in a small amount is excreted in breast milk.

Application for violations of liver function

Contraindications hepatic dysfunction.

Patients with liver failure in the early treatment of fluvoxamine should be administered in low doses under close supervision of a physician.

If you have symptoms caused by an increase in liver enzymes, fluvoxamine should be discontinued.

Application for violations of renal function

Patients with renal insufficiency in the early treatment of fluvoxamine should be administered in low doses under close supervision of a physician.

Use in children

is contraindicated in children younger than 8 years old.

The use in elderly patients

In elderly patients a dose of fluvoxamine should always improve more slowly and with great care.

If depression, usually there is a high likelihood of suicide attempts, which may persist until a sufficient remission.

To use caution in patients with a history of instructions cramps. With the development of epileptic seizure treatment with fluvoxamine should be discontinued.

Patients with hepatic or renal insufficiency in the early treatment of fluvoxamine should be administered in low doses under close supervision of a physician.

If you have symptoms caused by an increase in liver enzymes, fluvoxamine should be discontinued.

In elderly patients a dose of fluvoxamine should always improve more slowly and with great care.

There are reports on the development of ecchymosis and purpura in the application of the electoral serotonin reuptake inhibitors. With this in mind, it should be used with caution in these drugs, particularly in conjunction with drugs that affect platelet function (eg atypical antipsychotics and phenothiazines, many tricyclic antidepressants, NSAIDs, including acetylsalicylic acid), as well as patients with bleeding history.

In the period of treatment is not allowed alcohol consumption.

From – due to lack of clinical experience with fluvoxamine is not recommended for the treatment of depression in children.

Effects on ability to drive vehicles and management mechanisms

In patients whose activities are connected with the need to concentration and speed of psychomotor reactions, fluvoxamine should be used with caution until the final determination of individual response to treatment.

Treatment of MAO inhibitors should be discontinued 2 weeks prior to initial use of fluvoxamine.

fluvoxamine may inhibit the excretion of drugs metabolized with the participation of microsomal liver enzymes.

In an application with MAO inhibitors, there is the possibility of serotonin syndrome, particularly when an application with non-selective irreversible MAO inhibitors.

In an application increases plasma concentration of alprazolam, bromazepam, diazepam and amplify their side effects due to the fact that fluvoxamine inhibits the metabolic processes of these benzodiazepines.

In an application increases plasma concentration of amitriptyline, clomipramine, imipramine, maprotiline, trimipramine, driven by – apparently that fluvoxamine is a noncompetitive inhibitor of isoenzyme CYP1A2, with the participation of which is the process of N – demethylation of these antidepressants

In an application c buspirone may decrease its effectiveness; with valproic acid – may increase the effects of valproic acid; warfarin – warfarin may increase the concentration in plasma and the risk of occurrence of bleeding; with galantamine – increases the likelihood of increased side effects of galantamine; haloperidol – increases lithium plasma concentration.

In an application increases the concentration of carbamazepine in plasma, which is due to inhibition of its metabolism in the liver, primarily by suppressing the activity of CYP2D6 isoenzyme influenced by fluvoxamine.

In an application significantly increases the clozapine plasma concentration that some patients accompanied by the development of toxic effects of clozapine.

In an application may be reduced clearance of caffeine and strengthening its effects. This reaction is due to the fact that fluvoxamine largely inhibits isozyme CYP1A2, which is the primary enzyme responsible for metabolism of caffeine.

While the use of metoclopramide, a case of extrapyramidal disorders.

While the use of olanzapine, olanzapine increases the concentration in plasma; with propranolol – increased propranolol plasma concentration, which, in – apparently due to inhibition of cytochrome isoenzymes fluvoxamine the P450, involved in the metabolism of propranolol.

While the use of theophylline increases theophylline plasma concentration that leads to the development of toxic reactions. This reaction is due to the fact that fluvoxamine largely inhibits isozyme CYP1A2, which is the main enzyme responsible for the metabolism of theophylline.

With simultaneous use of reduced clearance of tolbutamide and its metabolites, which is due to inhibition of isozyme CYP2C9.

There are some reports of increased side effects of phenytoin when an application with fluvoxamine.

In an application slows metabolism and decreases clearance of quinidine.

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