Last Updated on February 19, 2017 by Dr.Derek Fhisher
Most popular brand: Prevacid
Active ingredient: Lansoprazole
Available dosage forms: 15, 30 mg
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Lansoprazole general information
Lansoprazole, known also as Prevacid, is regularly taken once every day for 14 days. Drugs like Omepraxole or Lansoprazole are able to heal inflammation within the esophagus quite quickly. At times, surgery is advised in case the medicines aren’t responding well to control the stomach ulcer. GERD, unfortunately can’t be cured at present but it really can be contained with using medications.
There’s a condition referred to as Visceroptosis or Glenard syndrome at which stomach acid secretion and motility is altered owing to its sunken place in the abdomen. Barrett’s esophagus takes place when chronic acid reflux or esophagitis isn’t controlled. Increase in gastrin production can also lead to high degrees of calcium within the blood (Hypercalcemia) which can likewise cause GERD. It is not advisable to breast feed when taking Amoxil.
It is thought that obstructive sleep apnea too can cause GERD. Melatonin is, in addition, famous as a sleep agent. H2 blockers may be used to take care of mild to moderate instances of acid indigestion and heartburn. Treatment is, in addition, needed to stop long-term damage.
Amoxil can trim the efficacy of contraceptive pills so you ought to take more precautions whilst utilizing it. The usage of some non-steroidal anti-inflammatory drugs like prednisolone. There’s also a much more powerful category of drugs called proton pump inhibitors. This particular product has a penicillin.
It’s not something to worry about in case you have heartburn occasionally. It can help to eradicate heartburn by lessening the acidity in your stomach. In addition, It augments your metabolism.
Litmus paper is usually utilised to try for acidity and can really be purchased in local health stores to try your precise pH level. Alternatively, the solutab could be mixed with a little bit of water, dissolved, then swallowed. Dexlansoprazole is taken once every day, usually prior to a meal. The vinegar isn’t just a favorite choice as acid reflux medicine, as additionally, it contains organic bacteria-fighters which has long since proven to be advantageous to health.
Some individuals don’t have any symptoms whatsoever. There are many other cures for anxiety that might be more effective based on the scope and severity of your own anxiety. If still medications aren’t effective along with the symptoms become much more severe it’s absolutely necessary that you see a physician. To be able to keep the disorder in order and also to prevent further complications, people who have chronic kinds of acid reflux need an ideal medication treatment.
If stomach acid has been low for a while, there could be bacteria that must be eliminated. One surefire way to prevent the potential deficiency will be certain to take a supplement. Along with taking good high quality supplements, you need to eat foods that have essential chromium like meat, poultry, dairy goods, seafood, grain, vegetables and fruits. In reality, I haven’t attended to any cases of individuals who lost weight, but didn’t lose the acid reflux.
When I visit a doctor it’s for diagnostic purposes only. The alternative of utilizing medication, in cases where it deems it necessary, doesn’t represent the best solution to the issue. It really is taken for just two weeks and also the regimen may be repeated after 4 months. If more than one dose is missed, or if it’s required to set a new dosage I schedule, get in touch with your physician or pharmacist.
The discomfort and pain connected with acid reflux is quite common around the globe. One of the organic remedies to ease the symptoms of acid reflux is cinnamon, another of the oldest spice in the whole world. Beyond that, a dry cough might be caused by a handful of conditions. There are a number of rare cases when treatment isn’t powerful and other measures should be applied.
You’d be surprised how frequently a building can cause you to feel sick constantly. There are several reasons that this is how it is. There are many of alternatives. If not one of the dietary changes or medications you’ve tried can put a limit to your own acid reflux, then surgery can be viewed as a final resort.
In case your acid reflux medicine isn’t helping lessen your symptoms then surgery could be considered. In combination with taking acid reflux medication, you need to be advised additionally to keep an eye on your own diet. Other things that put patients in danger of Vitamin B-12 deficiency is elderly folks, alcoholics, patients with dementia, patients which have had a tiny bowel resection in addition to AIDS patients. Here are a couple of steps which you can take in case your aim is to alkalize your own body.
When an individual loses weight and starts to drink a whole lot of water, rather than diet sodas, the acid reflux disappears. Interestingly enough, I’ve observed that every time an individual loses weight the reflux as well as the acidity also disappears. This contributes to progression of numerous degenerative diseases too. There’s no preference for absolutely any specific sex or age as Ulcers might occur at the similar proportion in men as in women and will affect patients at any given age.
Description of the active ingredient lansoprazole / Lansoprazolum.
Formula: C16H14F3N3O2S, chemical name: 2 – [[[3 – methyl – 4 – (2,2,2 – trifluoroethoxy) – 2 – pyridyl] methyl] sulfinyl] benzimidazole
Mode of action: protivoyazvennoe.
lansoprazole blocks the formation of hydrochloric acid in the final step. Lansoprazole is transformed into a sulfonamide (the active form of the drug) in the tubules of parietal cells of the gastric and irreversibly reacts with SH – groups of proton pump (H + – K + – ATPase). Lansoprazole reduces stimulated (insulin, pentagastrin, food) and basal acid secretion and secretion volume. The degree and rate of inhibition of gastric acid secretion are dose dependent: when receiving 30 mg and 15 increases through the pH 2 – 3 and 1 – 2 hours, and secretion decreased to 80 – 97%, respectively. Proton pump activity is recovered with a half life of 30 – 48 hours. The average pH of gastric juice is increased to 2.9. When you remove the drug acid level is less than 50% of basal within 39 hours, not marked rebound increased secretion. In patients with Zollinger syndrome – Ellison drug lasts longer
lansoprazole inhibits the formation of pepsin (pepsinogen content in blood plasma increases).. Lansoprazole by increasing the oxygenation of the mucosa and secretion of bicarbonate has a gastroprotective effect. Lansoprazole inhibits the growth of Helicobacter pylori (lowest antimicrobial concentration is 0.78 – 6.25 mg / l), promotes the formation of mucosal immunoglobulin A specific to Helicobacter pylori, H. pylori increases the activity of other means. It slows the evacuation of the stomach contents. Lansoprazole approximately 17% reduction in blood flow to the gatekeeper and the duodenum, the antral stomach. Inhibition of secretion is accompanied by an increase in the nitrate content and increase the amount of nitrozobaktery in gastric secretions. Lansoprazole increases gastrin in the blood plasma by 50 – 100% (concentration of gastrin after 2 months of therapy reaches a plateau and goes back to the initial values after discontinuation of the drug). Lansoprazole is effective in the treatment of duodenal ulcers and gastric resistant H2 – blockers. Lansoprazole provides faster relief of symptoms and healing of duodenal ulcer (after 4 weeks of therapy at a dose of 30 mg per day of 85% heal duodenal ulcers)
After treatment recurrence of peptic ulcer is 55 -. 62%. Complete cure under reflux esophagitis seen in 88.7% by the end of 8 weeks of reception (30 mg daily). Lansoprazole does not exhibit anticholinergic or antihistamine properties.
Lansoprazole is usually used in the form of pellets, which are acid-resistant coating and are not destroyed in the stomach, as the drug is acid-fast. Lansoprazole is almost completely absorbed by the small intestine into the systemic circulation. In cirrhosis of the liver slows down the absorption. The absolute bioavailability is greater than 80%, 2-fold decreases in food intake (antisecretory effect is attenuated). The ingestion of 30 mg maximum concentration is 0.75 – 1.15 mg / l is achieved in 1.5 – 2.2 hours (about 1.7 hours), the maximum concentration is achieved more rapidly at the reception in the morning. When receiving from 15 mg to 60 is a linear pharmacokinetics, serum concentrations proportional to the dose and pharmacokinetic parameters constant drug accumulation occurs. The plasma protein binds to 97 – 99% (at a concentration of 0.05 – 5.0 g / ml). The volume of distribution of 0.5 l / kg. Lansoprazole is well into the tissue, including in the parietal cells of the stomach
The half-life in healthy volunteers was 1.5 hours in elderly patients -. 1.9 – 2.9 hours in patients with impaired functional status liver – 3.2 – 7.2 hours. The half-life is shortened in case of violation of renal function. Lansoprazole is metabolized in the liver with the cytochrome P450 enzyme system, thus formed hydroxy -, sulfinyl – and sulfonproizvodnye. Lansoprazole is displayed in the form of two major inactive metabolites in the bile (2/3 dose) and urine (the magnitude and rate of excretion of kidney failure has no significant effect)
lansoprazole causes hyperplasia of ECL -. Cells (enterochromaffin cells), increases the frequency epithelial metaplasia of the gastric mucosa and adenoma formation in the interstitial tissue of the testes when using high doses in experimental animals.
Peptic ulcer of the duodenum and stomach, non-ulcer dyspepsia, syndrome Zollinger – Ellison syndrome, benign gastric ulcer, reflux – esophagitis, erosive – ulcerative esophagitis, infection Helicobacter pylori (combination therapy).
How to use and dose of lansoprazole
lansoprazole ingested in the morning. Gastric ulcer: 30 – 60 mg per day for 4 – 8 weeks. Duodenal Ulcer 30 mg per day for 2 – 4 weeks. Non-ulcer dyspepsia: 15 – 30 mg per day for 2 – 4 weeks. Reflux – esophagitis 30 mg a day for 4 weeks. Erosive – ulcerative esophagitis: 30 – 60 mg per day for 4 – 8 weeks. Syndrome Zollinger – Ellison syndrome: the dose picked individually, you must provide a level of basal production of hydrochloric acid is less than 10 mmol per hour. Infection with Helicobacter pylori:. 2 times a day to 30 mg in the various schemes of combined treatment of Helicobacter
Before treatment, and after the obligatory endoscopic examinations to rule out malignancy (lansoprazole can mask the symptoms and delay the diagnosis is). It should be routinely carried out all the preventive diagnostic measures, which are aimed at the early detection of abnormal growths upper gastro – intestinal tract. Improving the well-being of patients in response to treatment lansoprazole does not preclude the gastric malignancy.
To use caution lansoprazole in patients with impaired hepatic function and in elderly patients (treatment start with half doses which are gradually increased to the recommended, but not more than 30 mg per day).
There is information that in the treatment of lansoprazole increases the risk of osteoporosis-related fractures of the ankle, hip or spine. The risk of fractures is increased in patients with a single receiving high doses or long-term treatment with lansoprazole (a year or more). When selecting the dose and duration of treatment preference is given the lowest dose and duration in accordance with the clinical condition of the patient. When there is a high risk of osteoporosis-related fractures should be used with caution
When used together with antacids should be administered at 1 -. 2 hours after or 1 hour before receiving lansoprazole.
Hypersensitivity, malignant tumors of gastro – intestinal tract, breast-feeding, pregnancy (especially I trimester).
Restrictions on the use
Abnormal liver function, advanced age, the age of 18 years (safety and efficacy not established use).
Pregnancy and breastfeeding
The use of lansoprazole is contraindicated in the I trimester of pregnancy. In II and III trimesters of application is possible if the supposed benefit of therapy up the possible risk to the fetus. At the time of lansoprazole therapy must stop breast-feeding (it is not known whether lansoprazole into breast milk in women allocated). Lansoprazole and its metabolites are excreted in the milk of rats.
Side effects of lansoprazole
Digestive system: diarrhea, nausea, decreased or increased appetite, abdominal pain, constipation, candidiasis gastro – intestinal tract, ulcerative colitis, increased activity of bilirubin and liver enzymes (alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, lactate dehydrogenase, gamma – glutamyl transferase), irregular stools, cardiospasm, anorexia, cholelithiasis, dry mouth, colitis, dyspepsia, enteritis, dysphagia, regurgitation, stenosis of the esophagus, esophagitis, esophageal ulcers, changes in stool color, polyps fundus of the stomach, flatulence , gastritis, gastro – intestinal bleeding, gastroenteritis, glossitis, increased salivation, vomiting, melena, mouth ulceration, rectal bleeding, stomatitis, tenesmus, ulcerative colitis, thirst
The nervous system and sensory organs: headache, dizziness, malaise, depression, drowsiness, anxiety, insomnia, amnesia, anxiety, apathy, dementia, convulsions, depersonalization, hallucinations, emotional lability, double vision, hyperkinesia, hemiplegia, increased / decreased libido, tremor, paresthesia , amblyopia, cataract, blepharitis, conjunctivitis, glaucoma, photophobia, loss of visual fields, retinal dystrophy, deafness, tinnitus, otitis media, distortion or loss of taste, parosmiya
The respiratory system:. coughing, rhinitis, pharyngitis, an infection or inflammation of the upper respiratory tract, asthma, dyspnea, bronchitis, hemoptysis, hiccups, epistaxis, laryngeal tumors, pneumonia, sinusitis, pulmonary fibrosis, stridor
Cardio -. vascular system and blood: arrhythmia, angina pectoris, bradycardia, hypotension, hypertension, tachycardia, syncope, collapse, myocardial infarction, thrombocytopenia (with hemorrhagic manifestations), anemia, hemolysis, lymphadenopathy
Urogenital system. : dysuria, menstrual irregularities, gynecomastia, nephrolithiasis, impotence, polyuria, pain in the urethra, vaginitis, problems with the reproductive function of women, frequent urination, symptoms of dysfunction of the male gonads (testes)
Endocrine system: hypothyroidism, diabetes, thyrotoxicosis
Musculo – skeletal system:. arthritis, arthralgia, muscle cramps, myasthenia, myalgia, synovitis
skin photosensitivity, alopecia, erythema multiforme, acne, contact dermatitis, maculo – papular rash, pruritus, dystrophic nail changes, rash, sweating, skin carcinoma
Allergic reactions: skin rash
Metabolic disorders:. , dehydration, vitamin deficiency, gout, hypoglycemia, hyperglycemia, weight loss, peripheral edema
General disorders:. fatigue, bloating, allergic reaction, chest pain, back pain, neck pain, swelling, pain in the pelvis, fever, flu-like symptoms, chills.
lansoprazole Interaction with other substances
Sucralfate reduces the bioavailability of lansoprazole by 30% (should be an interval of 30 – 40 minutes between doses of these drugs). Lansoprazole reduces clearance (10%) of theophylline. Antacids that contain magnesium hydroxide and algeldrat, when used in conjunction with lansoprazole may decrease the absorption of the latter. Possible interactions with drugs that are metabolized by the cytochrome P450 enzyme system. Simultaneous use of tacrolimus and lansoprazole may increase tacrolimus concentrations in blood serum. Especially tacrolimus in the blood serum was significantly increased in patients who are slow metabolizers by isoenzyme CYP2C19. Lansoprazole slows down the absorption of digoxin, ampicillin, ketoconazole, iron salts, cyanocobalamin. Lansoprazole can change pH – dependent absorption of drugs that are groups of bases (acceleration) and acids (deceleration). Amoxicillin mutually increases the risk of adverse reactions from the gastro – intestinal tract when used in conjunction with lansoprazole. Against the background of lansoprazole reduced the risk of gastric mucosa NSAIDs, corticosteroids. Do not use with lansoprazole rilpivirine as rilpivirine possible a significant reduction in blood concentration. Lansoprazole is compatible with the diazepam, antipyrine, ibuprofen, oral contraceptives, indomethacin, phenytoin, propranolol, prednisone, warfarin.
The symptoms of overdose of lansoprazole is not described (single dose of 600 mg clinical manifestations of overdose are not accompanied). In case of overdose, the patient monitoring is recommended, carrying out symptomatic and supportive treatment; Hemodialysis is ineffective.
Trading names of drugs with the active ingredient lansoprazole
Akrilanz® Lanzabel Lanzap®