Last Updated on April 28, 2021 by Dr.Derek Fhisher
Most popular brand: Mevacor
Active ingredient: Lovastatin
Available dosage forms: 10, 20 mg
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Lovastatin general information
Don’t take lovastatin if you’re pregnant. Don’t take lovastatin and niacin in case you are pregnant. Don’t breast-feed while you’re taking lovastatin and niacin. Don’t breast-feed while you’re taking lovastatin.
Alcohol easily gets absorbed into the little intestine, and as soon as it reaches the liver, the hepatic cells have to work difficult to metabolize huge quantities of alcohol. Niacin is, in addition, present in several multivitamins and nutritional supplements. Grapefruit and grapefruit juice might interact with lovastatin and cause unwanted side outcomes. Take lovastatin completely as directed.
If your physician has prescribed Mevacor or another statin drug, learn why. Don’t miss any dose or quit taking the drug by yourself. Practice the directions on your own prescription label thoroughly and ask your own doctor or pharmacist to clearly explain any part you don’t understand. Be certain to tell your physician and pharmacist about all of the products you use (including prescription medications, nonprescription medications, and herbal products).
At a great body temperature, all of the functions which are being carried out by various organs can occur with no hindrance. Low body temperature caused by hypothyroidism is regularly observed within the morning. When the kidneys aren’t able to accomplish this, the blood volume may increase, which then, may elevate blood pressure. Myoglobin can result in kidney failure and maybe even death.
Many drugs shouldn’t be used at the similar time. The side effects can be mild or severe, conditioned upon the age and total well-being of the patient. Possessing both, sedative and anticholinergic properties, it’s therefore employed in the treatment of allergies. Therefore, the wise point to do would be to talk with your doctor about the precautions that you want to follow while taking this antihypertensive drug.
While moderate drinking might not lead to harm, alcohol abuse is surely related to various serious ailments. In addition, There are many possible very serious health complications as well as those two. Older patients are somewhat more possible to suffer from the side results and could require close observation. Heavy drinkers are also at an elevated risk of creating kidney disease.
Use effective birth control to prevent pregnancy throughout the time you’re taking lovastatin. Pick out the medicine within the evening, unless your physician tells you otherwise. You shouldn’t take lovastatin if you’re pregnant or breast-feeding, or when you have active liver disease. Tell your physician straight away if you experience any unexplained muscle malady, tenderness, or weakness when taking lovastatin.
Lovastatin can give rise to a condition that results within the breakdown of skeletal muscle tissue, resulting in kidney failure. In rare situations, lovastatin can lead to a condition that results within the breakdown of skeletal muscle tissue, resulting in kidney failure. Lovastatin shares side effects, for example liver and muscle damage connected with all statins. When used together with food regimen, weight reduction, and exercise, lovastatin may decrease the chance of heart attack, stroke, and heart surgery.
Some side effects might occur that usually don’t need medical attention. In conclusion, we can say, in case you are taking flomax, and notice any one of the aforementioned unwanted side effects, don’t delay in contacting your doctor to elucidate the circumstance, and block the long-term ill consequences. This isn’t a comprehensive record of side results and others can occur. These weren’t thought of as common unwanted side effects, nevertheless they still must be mentioned.
Tell your physician straight away if you’re pregnant or intend on becoming pregnant before taking lovastatin. Speak to your doctor about the risks and advantages of utilizing lovastatin whilst breastfeeding. Call your physician for medical advice regarding side effects. You ought not take lovastatin in case you are allergic to it, in case you are pregnant or breast-feeding, or when you have liver disease.
Well, various research have established excessive usage of alcohol among the usual causes for hypertension. Consulting a doctor on how best to manage intake founded on the ingestion of both of these medications is essential, and may end up being life-threatening if not considered. In rare instances, lovastatin and niacin can lead to a condition that results within the breakdown of skeletal muscle tissue, resulting in kidney failure. Take a peek at this organic cholesterol lowering formula and learn how it could help significantly reduce your cholesterol levels as well as being able to promote overall heart health.
Withdrawal symptoms of prednisone are grave in comparison to other medications, especially in the event of long-term prednisone usage. Drugs for example lisinopril can assist in averting medical emergencies including acute congestive heart failure or even a heart attack. So in regards to functioning, these medications are not any different from one another. Well, there’s another listing of medications that shouldn’t be used in any way with lovastatin, since they can allow you to be at increased risk of the most important side effects I simply mentioned.
Lovastatin (Lovastatin): instruction, and the use of a formula
The Latin name of the substance Lovastatin
Lovastatinum ( genus. Lovastatini)
[1S – [1alpha (R *), 3alpha, 7beta, 8beta (2S *, 4S *), 8a beta]] – 2 – methylbutanoic acid 1,2,3,7,8,8a – hexahydro – 3 , 7 – dimethyl – 8 – [2 – (tetrahydro – 4 – hydroxy – 6 – oxo – 2H – pyran – 2 – yl) ethyl] – 1 – naphthalenyl ester
Gross – formula
Therapeutic agents Lovastatin
The nosological classification (ICD – 10)
Feature substance Lovastatin
The white non-hygroscopic, crystalline powder; insoluble in water, slightly soluble in alcohol.
Mode of action – lipid-lowering, cholesterol-lowering.
It stops the initial and intermediate stages of cholesterol biosynthesis in the liver. The body forms a free beta – hydroxy acid, which competitively inhibits 3 – hydroxy & minus; 3 – methylglutaryl – coenzyme A – reductase (HMG – CoA – reductase) and disrupts the conversion of HMG – CoA to mevalonate ; the result is limited to the synthesis of cholesterol, increasing its catabolism, decreases plasma levels, decreases in LDL concentration. containing large amounts of cholesterol. It inhibits the synthesis of VLDL and triglycerides, increases HDL concentrations. Significantly reduces the amount of apolipoprotein B (a part of LDL) circulating LDL and other components.
In the digestive tract is absorbed slowly and incompletely (approximately 30% of the dose), fasting reduces the absorption of 30%. C max is achieved in 2 hours, but then the plasma level decreases rapidly, accounting for over 24 hours 10% of the maximum. As lovastatin and its beta – hydroxy acid metabolite generally circulate in the bloodstream associated with plasma proteins form (about 95%). A stable equilibrium concentration of lovastatin (and its active derivatives) for assigning one time per day at night (cholesterol is synthesized mainly at night) is reached 2 – 3 – day treatment and is 1.5 times the single dose posed. Penetrates through the BBB and placental barrier, accumulates in the liver, which is oxidized to a beta – hydroxy acid, its 6 – hydroxy derivative and other metabolites, some of which remain active (inhibit HMG – CoA – reductase).. 10% of the drug is excreted by the kidneys, 83% ; intestines. The pronounced hypolipidemic effect develops after 2 weeks. maximum ; for 4 – 6 weeks.
Application of the substance Lovastatin
Hypercholesterolemia: a primary high LDL content (Types IIa and IIb) in the absence of effect of diet, combined with hypertriglyceridemia (hyperlipoproteinemia type IIb); atherosclerosis.
Hypersensitivity, renal dysfunction, severe hepatic impairment, a persistent increase in transaminase levels in blood plasma, pregnancy, lactation, children’s age.
Application of pregnancy and breastfeeding
Category effects on the fetus by FDA ; X.
Side effects of substance Lovastatin
Abnormal liver function, increased levels of transaminases, dyspepsia, flatulence, nausea, vomiting, heartburn, dry mouth, taste disturbance, anorexia, constipation / diarrhea, hepatitis, headaches, muscle pain, myopathy, rhabdomyolysis, weakness, pain chest, arthralgia, insomnia, paresthesia, dizziness, mental disorders, convulsions, optic atrophy, cataracts, allergic reactions (skin rash, etc.).
Kolestiramin and bile acids enhance the effect. Cyclosporin increases the plasma levels of the active metabolites of lovastatin. Fibrates, niacin, itraconazole and other azole antifungals, erythromycin or tacrolimus increase the risk of myopathy, indirect anticoagulants (coumarin) ; bleeding.
Dosing and Administration
Inside, during the meal; in hypercholesterolemia ; 10 – 20 mg once daily for dinner; atherosclerosis ; 20 – 40 mg. With the lack of effectiveness of the dosage is increased (at intervals of not less than 4 weeks) to 60 – 80 mg in 1 – 2 reception.
Precautions substance Lovastatin
Patients taking immunosuppressants, or severe renal dysfunction, the dose should not exceed 20 mg / day. During treatment, patients must be on a standard diet low in cholesterol. It is recommended to carefully monitor the general condition (appearance of muscle pain or weakness, especially on the background of fever, requires the removal of lovastatin), periodically check the blood cholesterol levels and liver function tests are carried out.
It may increase the levels of creatine phosphokinase and transaminase (should be considered in the differential diagnosis of chest pain).