Last Updated on February 19, 2017 by Dr.Derek Fhisher

Accupril Quinapril 5, 10, 20 mg
Most popular brand: Accupril
Active ingredient: Quinapril
Available dosage forms: 5, 10, 20 mg
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Quinapril general information

Even Though it is very effective in treating high blood pressure, like quite a few other medications, additionally it may generate a few unwanted side effects in a few people. On the opposite hand, secondary hyperhidrosis is distinguished by generalized sweating that’s caused because of a medical condition or the application of certain drugs. Some patients don’t respond sufficiently to this medication alone, hence it may also be utilized in conjunction with other drugs.

It’s always best to consult with a doctor. It’s not a prescribed medication. It might be an important source of patient over treatment. Sometimes, symptomatic treatment might be considered.

Phentermine, which truly is a drug that’s prescribed for controlling obesity, is also know to result in night sweats in people experiencing sleep apnea. Consequently, such individuals should exercise caution when using this drug. The dosage differs from individual to individual, based on individual need and also the stage of hypertension the individual is experiencing. Side effects could be serious and frequently the drug is contraindicated or should be withdrawn. On the opposite hand, fatigue might be experienced by about 4.5% of the individuals who are on this drug, according to clinical studies.

Medication taken for nausea while pregnant can also cause sweating. Medications to control these conditions could also trigger night sweats. In addition, abnormal sweating might even become a withdrawal symptom. Such sweating is, in addition, accompanied by heartburn, excessive desire to urinate during the night, sunken chest (in children) during sleep as well as dry mouth each morning. Additionally, This may lead to night sweats. And so, if you experience night sweats, don’t strive to self-diagnose the issue.

Pregnant and breastfeeding women, together with those attempting to conceive should talk to their own physician concerning the use of the hypertension medication. Typically these medications are suggested for all those patients who are unable to take ACE inhibitors on account of their side effects, like, allergy and cough. More tests may be necessary to set a comprehensive symptom picture linked to the raised blood pressure. There are lots of other tests that might be needed to make the proper diagnosis.

Heart medicine that’s healthy as well as happy! So they’ren’t usually the very first medication you’d be prescribed to decrease your blood pressure. Then ask your physician to compare your blood pressure readings at an ulterior date to learn what progress you’ve made.

About 1% of individuals with higher blood pressure don’t seek medical care until the superior blood pressure is quite severe, a condition called malignant hypertension. For those with diabetes, beta blockers may block hints of low blood glucose, including dizziness or even a rapid heartbeat. Beta blockers are not normally prescribed before diuretics are tried. The most usual side effect of the drug is edema. They have adverse impacts on cholesterol and boost LDL with all the exception of Indipamide.

Everyone needs enough shut eye as a way to keep a healthy lifestyle. Not to mention deprivation of day-to-day slumber can eventually bring about other health concerns. That’s because too little sleep can lead to many unfortunate consequences far past the standard groggy feeling. Several people are unable to sleep, and it is probably because of the fact which they have a terrible sleep cycle.

Which each surgery, there’s risk. To avoid this issue, doctors can fit a device across the penis that’ll record just how many erections occur during an individual night’s sleep. Other theories indicate that night-time erections occur so as to avoid a complete bladder from voiding during sleep.

QUINAPRIL (quinapril)

In the treatment of hypertension the usual starting dose is 2.5 mg 1 time / day maintenance dose – 20 – 40 mg in 1 or 2 divided doses, sometimes – up to 80 mg / day,.

In chronic heart failure the initial dose 2.5 mg maintenance dose – 5 – 20 mg / day in 2 divided doses usually, sometimes – up to 40 mg / day,.

The maximum doses: when administered a single dose – 20 mg daily – 80 mg.

From the nervous system: may dizziness, weakness, headache; rarely – paresthesia, mood disorders and sleep.

Cardio – vascular system: is possible hypotension; rarely – tachycardia.

From the digestive system: are possible dyspeptic symptoms (including dryness in the mouth, violation of appetite); rarely – stomatitis, abdominal pain, pancreatitis, cholestatic jaundice.

From a metabolism: can hyperkalemia, hyponatremia; rarely – proteinuria, increased levels of urea and creatinine in the blood (mainly in patients with impaired renal function).

The respiratory system: may be a dry cough, bronchitis, rhinitis.

From the hematopoietic system: , rarely – neutropenia, agranulocytosis, thrombocytopenia, anemia.

From the urinary system: may impair renal function.

From the reproductive system: , rarely – impotence.

Allergic reactions: are possible skin rash, angioedema.

Dermatological reactions: is rare – alopecia.

Other: , rarely – muscle spasms.


Angioedema in history associated with treatment with ACE inhibitors, hereditary and / or idiopathic angioedema; pregnancy, lactation (breastfeeding); childhood and adolescence to 18 years; simultaneous application of aliskiren and aliskirensoderzhaschimi drugs with angiotensin II receptor antagonists or with other drugs that inhibit the RAAS (dual blockade of the RAAS), in patients with diabetes mellitus or in patients with diabetes with organ lesions – targets (diabetic nephropathy), with dysfunction kidney (GFR of less than 60 ml / min / 1.73 m 2), with hyperkalemia (5 mmol / l), with chronic heart failure and hypertension.

Pregnancy and breastfeeding

Do not use this during pregnancy and lactation (breastfeeding). When it should be lifted immediately established pregnancy.

quinapril excreted in breast milk.

Application for violations of liver function

Contraindications hepatic dysfunction.

Application for violations of renal function

Contraindications renal impairment, condition after kidney transplantation. Patients with moderate and mild impairment of renal function requires correction dosing regimen based on QC values.

Use in children

Do not use in children under 14 years.

We do not recommend use in severe impaired renal function (with CC less than 30 ml / min), the primary disease or hepatic dysfunction, severe heart failure decompensation phase, as well as children up to 14 years. Patients with impaired renal function requires correction dosing regimen based on QC values.

Patients with severe hypertension or treatment of quinapril should be started in the hospital concomitant heart failure. Before treatment, patients need to study renal function. During treatment it is necessary to monitor kidney function, electrolyte composition of the blood, the level of liver enzymes, as well as peripheral blood picture. This is especially true of patients with autoimmune diseases receiving immunosuppressive drugs. At deficiency of fluid and sodium before treatment is necessary to correct these violations.

While the use of potassium-sparing diuretics and potassium supplements requires regular monitoring of the level of potassium in the blood.

During treatment quinapril hemodialysis can not be performed with the use of polyacrylonitrile membranes, as increased risk of anaphylactic reactions.

The application period quinapril avoid alcohol because there is a strengthening of the last in patients receiving quinapril.

Effects on ability to drive vehicles and management mechanisms

To apply caution in patients whose activities are connected with the need to concentration and speed of psychomotor reactions, especially early in treatment, as well as the transition to other drugs.

While the use of tetracycline antibiotics, drugs that interact with magnesium may reduce the absorption of tetracycline antibiotics and other drugs that interact with magnesium, because Quinapril contains large amounts of magnesium.

In an application with antihypertensive agents is synergistic antihypertensive effect.

While the use of potassium-sparing diuretics (including with spironolactone, triamterene, amiloride), potassium supplements, salt substitutes and food supplements containing potassium may develop hyperkalemia (especially in patients with impaired renal function), ie, .to. ACE inhibitors reduce the amount of aldosterone, resulting in potassium retention in the body to limit background removal or potassium intake of additional.

In an application with the “loop” or thiazide diuretics increased antihypertensive effect. Severe hypotension (especially after the first dose of a diuretic) is shown on – apparently due to hypovolemia, which leads to a transient enhancement of the hypotensive effect of quinapril. Increased risk of renal dysfunction.

In an application with NSAIDs may reduce the effectiveness of quinapril.

While the use of allopurinol, immunosuppressants, cytostatics, procainamide there is a risk of leucopenia.

While the use of insulin, sulfonylureas hypoglycemic agents may develop hypoglycemia due to increase glucose tolerance.

In an application with lithium carbonate increases the concentration of lithium in blood serum, accompanied by symptoms of lithium intoxication.

While the use of co – trimoxazole cases of hyperkalemia are described.

With the simultaneous use of ACE inhibitors and drugs gold (sodium aurothiomalate, w / w) describes a symptom, including facial flushing, nausea, vomiting and decreased blood pressure.

Patients simultaneously receiving therapy with inhibitors of the mTOR enzyme (eg, temsirolimus) or inhibitors of DPP – 4 (gliptiny) or estramustine may be at greater risk of developing angioedema.

In an application with quinapril may increase the action of ethanol.

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