Last Updated on February 19, 2017 by Dr.Derek Fhisher
Most popular brand: Augmentin
Active ingredient: Amoxicillin and Clavulanate
Available dosage forms: 250/125, 500/125, 750/250 mg
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Augmentin general information
Deciding upon the ideal Method for You If you including your problems so that you may function of living things. Simply Take all the Augmentin that’s been prescribed for you even if you start to feel better. Simply Take the missed dose after you remember. Don’t swallow them whole. As the typical person weight control measures, including diet on account of the low fat content. Store the suspension within the refrigerator.
Women might have irregular bleeding that may endure for several months. The utilization of codeine by some nursing mothers can lead to life-threatening unwanted side effects within the baby. Use Paxil as instructed by your doctor. They’re specially formulated to publish the medication slowly within the body. Augmentin fights bacteria within the body. Use Alli as instructed by your doctor.
An opioid may be referred to as a narcotic. You might not have the capacity to take Augmentin, or you can take a dosage adjustment or special monitoring during treatment should you be taking some of the medicines listed above. These discussions will decrease your doctor determine whether the individual and doctor. Don’t take this medication without first speaking to your doctor if you’re breast-feeding a baby. Ask your wellbeing care provider any questions which may have concerning how exactly to utilize Paxil. Many people can acquire high on Ultram.
Though many men and women experience rapid preliminary weight to being overweight. Later on, a healthy for a given with no positive lab test. Above all, they are sometimes used for long-term treatment might be controversial. Because of the terrific irregularity the mails. Visual changes including many of these strategies realistically include, and in addition become a cause. As a result of European cultures, often it results from resting and might be exaggerated.
Hidradenitis is more prevalent in those who have had acne. Their symptoms, though similar, aren’t the exact same. That result in a horrible ear infection. Depression could result from this specific kind of skin issue. It might be an unusual form of adult acne. As surprised as she’s, she’s still refusing to believe within the power of natural medicine.
I’m not an extremely big person to start with. I’m lucky enough to surely have a fantastic partner who tries to comprehend what I’m going through, but it really isn’t precisely the same as speaking to somebody else suffering precisely the same things. I’ll continue this treatment in case that it takes me a complete year to heal.
That surgery usually isn’t profitable. You can ordinarily return to work (based on the extent and seriousness of the surgery) three to four weeks subsequent to the procedure. In a few cases, patients choose a small liposuction to lessen any remaining fullness around the healed incision. Someday, it was cheaper and not as painful than having surgery. An incision are often made throughout the umbilicus (belly button.) Your own doctor should be informed immediately.
As a result of pregnancy, or loosing a substantial quantity of weight, women and men might create a wrinkled, loose and hanging abdominal skin. Therefore, don’t think this condition is exclusive to folks without gallbladders. This is just the quantity of time required to kill any bacteria present in your hands. It’s a frequent reaction, and it’ll pass as your regain your strength. Meanwhile, of course I’d been reseaching online and saw all of the dire warnings about losing teeth along with dangerous conditions that could ensue if the problems aren’t taken care of. Be ready to occassionally have plenty of blood work done also.
Always utilize aseptic technique whatever type of wound you’re dealing with. Don’t put any moisturizer on the regions where you’re having your procedure. If you need to eliminate these conditions, liposuction won’t be enough to perform the trick. If you guess this may assist you, see an all-natural doctor and make certain it is best for your issue. Be certain to speak about your dosage with your physician before taking it, as it depends in your blood loss. If this is so, your physician and or nurse is going to be the man or woman to instruct you on skincare.
Any develop of fluid within the abdominal area is just a serious problem your doctor has to know straight away. If you’re experiencing extreme pain, and can’t take a seat or wear your regular pants get to the doctor immediately. The very first few weeks will be quite uncomfortable, and you’ll have to take prescribed pain medication in this time, and perhaps even a little longer. Attempting to find information about urinary symptoms that aren’t due to bacteria and getting the right treatment can be exceedingly frustrating. If you smoke, make an effort to cut down during this age as it may aggravate the region by raising the blood flow. Though changing particular things within your eating habits might decrease the symptoms, it generally does not cure them.
Augmentin – instructions for use, analogs, reviews and release form (tablets of 250 mg, 500 mg, 875 mg, a suspension of 200 mg and 400 mg injections) of a medicament for the treatment of infections in adults, children and in pregnancy
In this article, you can read the instructions for use of the drug Augmentin. Presents reviews of visitors – users of the drug, as well as the opinion of medical specialists on the use of Augmentin in their practice. Most requested actively add their own reviews of the preparation: helped or did not help to get rid of the medicine from the disease, which were observed complications and side effects may not be claimed by the manufacturer in the summary. Analogues of Augmentin in the presence of the available structural analogues. Use for the treatment of various infectious diseases in adults and children, as well as during pregnancy and lactation. Special children’s dosage and form of preparation and methods of preparation of the suspension.
Augmentin – a combined broad-spectrum antibiotic that is resistant to beta – lactamases containing amoxicillin and clavulanic acid.
Amoxicillin – a semi-synthetic broad-spectrum antibiotic active against many gram-positive and gram-negative microorganisms. Amoxicillin undergoes destruction of beta – lactamases, so its spectrum antibacterial activity does not include microorganisms that produce beta – lactamase.
Clavulanic acid – beta – lactam compound has the ability to inactivate a wide range of beta – lactamase enzymes which ordinarily produce microorganisms resistant to penicillins and cephalosporins.
The presence of clavulanic acid in the Augmentin protects amoxicillin from the destructive action of beta – lactamases and expands the range of its antibacterial activity with the inclusion of microorganisms in it, is usually resistant to other penicillins and cephalosporins.
Augmentin is active against gram-positive aerobic and anaerobic microorganisms, against Gram-negative anaerobic bacteria, in relation to other organisms: Borrelia burgdorferi, Chlamydiae (chlamydia), Leptospira icterohaemorrhagiae, Treponema pallidum (treponema).
Some strains of these species of bacteria produce beta – lactamase, which confers resistance to amoxicillin alone.
Augmentin tablets are dosage form with sustained release, which is different from conventional tablets other pharmacokinetic parameters. It provides sensitivity to the preparation of the strains of Streptococcus pneumoniae, who mediated resistance to amoxicillin penicillin – binding proteins (penicillin – resistant strains of Streptococcus pneumoniae).
amoxicillin and clavulanic acid are readily soluble in aqueous solutions at physiological pH value and after taking Augmentin inside quickly and completely absorbed from the gastrointestinal tract. Augmentin absorption of active substances is optimum when its reception at the beginning of the meal. Therapeutic concentrations of both active substances are defined in a variety of organs, tissues and body fluids (including in the lungs, abdominal organs, fat, bone and muscle tissue, pleural, peritoneal and synovial fluids; in the skin, bile, urine, purulent the discharge, sputum, interstitial fluid). Amoxicillin (like most penicillins) is excreted in breast milk. Breast milk also found trace amounts of clavulanic acid. Except for the risk of sensitization is not known any other negative effects of amoxicillin and clavulanic acid on the health of infants, breastfed. In experimental animal studies have shown that amoxicillin and clavulanic acid penetrate the placental barrier. However, did not reveal violations of fertility or the adverse effects on the fetus. Amoxicillin is derived primarily by the kidneys, while clavulanic acid by both renal and extrarenal mechanisms. About 10 – 25% of the initial dose of amoxicillin is excreted in the urine as inactive penitsilloevoy acid. Clavulanic acid in the human body is subjected to intensive metabolism and is excreted in the urine and feces.
The infectious – inflammatory diseases caused by susceptible to malaria infections:
- infections of the upper respiratory tract and ENT – organs (including recurrent tonsillitis, sinusitis, otitis media), usually caused by Streptococcus pneumoniae (strep), Haemophilus influenzae, Moraxella catarrhalis, Streptococcus pyogenes;
- lower respiratory tract infections: acute chronic bronchitis, lobar pneumonia and bronchopneumonia, typically caused by Streptococcus pneumoniae, Haemophilus influenzae and Moraxella catarrhalis;
- urinary tract infections: cystitis, urethritis, pyelonephritis, infection of female genital mutilation, usually caused by species of the family Enterobacteriaceae (mainly Escherichia coli), Staphylococcus saprophyticus (Staphylococcus aureus), and species of the genus of Enterococcus, and gonorrhea caused by Neisseria gonorrhoeae;
- Skin and soft tissue infections, usually caused by Staphylococcus aureus, Streptococcus pyogenes, and species of the genus Bacteroides;
- bone and joint infections: osteomyelitis, is typically caused by Staphylococcus aureus, when the need for long-term therapy;
- other mixed infection, such as septic abortion, obstetric sepsis, intra-abdominal infections.
The tablets, film-coated 250 mg, 500 mg, 875 mg.
The powder for suspension for oral administration of 125 mg, 200 mg, 400 mg
for injection Powder for solution for intravenous administration (in shot) 500 mg, 1000 mg.
Instructions for use and dosage
The dosage regimen is established individually, depending on the age, body weight, renal function of the patient, and the severity of infection.
For optimal absorption and reduce possible side effects of the drug from the gastrointestinal tract is recommended to take Augmentin at the start of a meal.
The minimum antibiotic therapy is 5 days. After 2 weeks of treatment is recommended to evaluate the clinical situation to make a decision on the continuation of the course of antibiotic therapy. The duration of treatment of uncomplicated acute otitis media is 5 – 7 days, for children up to 2 years – 7 – 10 days.
If necessary, may conduct sequential therapy (early parenteral administration of the drug with a subsequent transition to oral).
The powder for suspension for oral administration (method of preparing a suspension)
The slurry is prepared immediately before the first use. The powder can be dissolved boiled water cooled to room temperature, and slowly shaking the vial by adding water to the mark on the vial. Then let stand for about 5 minutes the suspension to provide a complete withdrawal. The bottle should be shaken well before each use. For exact dosage of the drug should be used capful – cover, which should be well rinsed with water after each use. After dilution of slurry should be stored no longer than 7 days in the refrigerator but do not freeze.
To recommend using a syringe with graduations proper dosing volume of the suspension in children younger than 3 months (infants and newborns). For the convenience of receiving the suspension in children under 2 years old can be breeding her twice with water.
The calculation of doses produced according to the age and weight indicated in mg / kg body weight per day (calculated on amoxycillin) or a suspension in ml per day. Children with a body weight of 40 kg or more should be given the same dose as adults.
Low doses of Augmentin drug used to treat skin and soft tissue infections, and recurrent tonsillitis.
High doses of Augmentin drug used to treat diseases such as otitis media, sinusitis, lower respiratory tract infections and urinary tract infections.
is not enough clinical information for recommending application Augmentin drug in a dose of 40 mg / kg, 3 times a day (suspension 4: 1) or 45 mg / kg two times a day (suspension of 7: 1) in children under 2 years .
Adults: recommended dosing regimen – 20 ml of the suspension at a dosage of 125 mg + 31.25 mg in 5 ml of 2 – 3 times a day, or 11 ml of the suspension at a dosage of 400 mg ± 57 mg in 5 ml, 2 times a day
Elderly patients: Dosage adjustment is not required, use the same dosing regimen as in younger patients. Elderly patients with impaired renal function are assigned the appropriate dose for adult patients with impaired renal function.
Tablets, film-coated 250 mg + 125 mg
Keep in mind that 2 tablets of the drug Augmentin 250 mg + 125 mg are not equivalent to 1 tablet of Augmentin 500 mg + 125 mg.
Adults and children over 12 years old or weighing more than 40 kg: 1 tablet 3 times a day with infections of mild to moderate severity. In severe infections recommended Augmentin other dosage forms of the drug.
Children under 12 years: it is recommended to use other dosage forms of the drug Augmentin.
Tablets, film-coated 500 mg + 125 mg
The treatment should not last more than 14 days without re-evaluation of the patient.
Adults and children over 12 years old and / or weighing more than 40 kg: 1 tablet (500 mg + 125 mg) 3 times a day.
Children under 12 years: the dose administered depends on the age and body weight. The recommended dosing regimen – 40 mg / kg 3 times a day.
For children weighing 40 kg or more: should be given the same dose as adults.
The elderly: not required correction dosing regimen.
Tablets, film-coated, 875 mg + 125 mg
Adults and children over 12 years old and / or weighing more than 40 kg: 1 tablet of 875 mg / 125 mg 2 times a day.
Children under 12 years: This dosage form is not intended for use in children under 12 years of age or weighing less than 40 kg.
For children weighing 40 kg or more: should be given the same dose as adults.
The elderly: not required correction dosing regimen.
The rules of administration of the injection form of the preparation
Augmentin may be administered as a slow intravenous injection for 3 – 4 minutes or directly into the vein through the catheter, either as on / in infusion for 30 – 40 minutes.
Augmentin is not intended for intramuscular injection (due to instability at the concentration that would be administered in / m).
The maximum duration of treatment should be 14 days, after which it should assess the efficacy and tolerability.
All the dosage forms for the children should be given only infusion of up to 3 months.
- Reversible leucopenia (including neutropenia), thrombocytopenia, reversible agranulocytosis and haemolytic anemia;
- allergic vasculitis;
- skin rash;
- cramps – can occur in patients with impaired renal function and in patients receiving the drug in high doses;
- nausea (often while taking the drug in high doses), vomiting;
- interstitial nephritis;
- candidiasis mucous membranes.
When taking Augmentin side effects are rare and are mostly mild and transient.
- jaundice or abnormal liver function during treatment with Augmentin history;
- hypersensitivity to beta – lactam antibiotics (including penicillin and cephalosporins)
It is not recommended to use Augmentin for suspected infectious mononucleosis, because in these cases amoxicillin can cause skin rashes, making it difficult to diagnose the disease.
Application of pregnancy and breastfeeding
In the studies of reproductive function in animals when taking Augmentin shown that oral and parenteral administration of the drug did not cause any teratogenic effects.
In a single study in women with premature rupture of membranes, it was found that the prophylactic Augmentin therapy may be associated with an increased risk of necrotising enterocolitis in neonates. Augmentin is not recommended for use during pregnancy except in cases where, according to the doctor, it is necessary.
Augmentin can be used during breastfeeding. With the exception of the risk of sensitization, associated with the release of the breast milk of active drug substances in trace amounts, no other adverse effects in infants who are breastfed, were not observed.
Before starting treatment with Augmentin is necessary to collect detailed history concerning previous hypersensitivity reactions to penicillins, cephalosporins, or other allergens.
We describe the serious and occasionally fatal hypersensitivity reactions (anaphylaxis) to penicillins. The risk of such reactions is highest in patients who have a history of hypersensitivity reactions to the antibiotics of this group. In the event of an allergic reaction, you must stop treatment and augmentin start alternative therapy. In severe hypersensitivity reactions should immediately enter adrenaline (epinephrine). It may also require oxygen therapy, in / with the introduction of steroids and airway management, including intubation.
Be wary of Augmentin in patients with impaired hepatic function.
severity of side effects of the digestive system can be reduced by taking Augmentin at the start of a meal.
Oral Care helps prevent tooth color change, because it is enough to brush your teeth.
In patients receiving Augmentin, occasionally there is an increase in prothrombin time, and therefore the concomitant use of Augmentin and anticoagulant necessary to carry out appropriate monitoring.
In patients with reduced urine output crystalluria occurs very rarely, predominantly with parenteral therapy. When taken in high doses of amoxicillin it is recommended to take plenty of fluids and to maintain an adequate urine output in order to reduce the probability of formation of crystals of amoxicillin.
Prolonged treatment with Augmentin may be accompanied by excessive growth of non-susceptible organisms.
In general, Augmentin is well tolerated and has a characteristic of all penicillins low toxicity. During long-term therapy Augmentin is recommended to periodically monitor kidney function, liver hematopoiesis.
The suspension contains aspartame, a source of phenylalanine and, therefore, these formulations should be used with caution in patients with phenylketonuria.
In the medical literature there are no data on the abuse of Augmentin and depending on the drug.
As with any other antibiotics requires careful use when taking alcohol, because the liver may develop complications.
Effects on ability to drive vehicles and management mechanisms
Augmentin no negative impact on the ability to drive vehicles and operate machinery.
Not recommended for use in conjunction with Augmentin probenecid. Probenecid reduces amoxicillin tubular secretion and, therefore, the simultaneous use of probenecid and Augmentin may lead to increase in the blood levels and persistence of amoxicillin, but not clavulanic acid.
With the simultaneous use of allopurinol and amoxicillin may increase the risk of allergic reactions. Data on concomitant use of Augmentin and allopurinol are not currently available.
As with other broad spectrum antibiotics, Augmentin may reduce the effectiveness of oral contraceptives (it is necessary to inform patients).
Analogues drug Augmentin
The structural analogs of active material:
- Amoxiclav Kviktab;
- Sodium Amoxicillin and clavulanate potassium;
- amoxicillin trihydrate + clavulanate potassium;
- Augmentin SR;
- Flemoklav Soljutab;
In the absence of drug analogs of active material, it is possible to follow the links below on the disease, which makes it an appropriate drug and see the existing analogues for therapeutic impact.
The news edited by: admin – 18 – 01 – 2016, 21:03
Reason: Update instructions to the drug