Last Updated on February 19, 2017 by Dr.Derek Fhisher
Most popular brand: Glucotrol
Active ingredient: Glipizide
Available dosage forms: 2,5, 5, 10 mg
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Glipizide general information
In case you have taken the meal and extremely near the meal you’ve taken Byetta then you may suffer with stomach pain and nausea. Therefore it is very important to control your blood sugar constantly, and not only before going to the doctor. It’s likewise important your monitor your blood glucose commonly to avoid both low and high blood glucose. To get this done, your physician will insist on a superb diet and normal exercise. It’s highly advisable to take the missed dose when it’s remember, if it’s the time of next dose then more advisable to drop the missed one and continue with all the normal schedule.
The more information you’ve got about your blood glucose levels, the simpler it will be for you to truly control it. This may then automatically become section of your diet. You might also profit from this excellent seed and keep healthy for long time.
Diabetes or more popularly called blood glucose is really a disease whenever your body doesn’t regulate blood glucose level mainly because of the disturbance in the degree of insulin production. Gymnema is just a remarkable herb which is really a potent aid in blood-sugar related ailments including weight reduction and diabetes, or pre-diabetes. Whenever your cells ignore the insulin, as said above, it’s frequently known as insulin resistance. Your personal doctor may prescribe such a medicine in conjunction with sulfonylureas insulin, or possibly a category of drugs generally known as thiazolidinediones.
Hypoglycemia, or very low blood glucose, occurs from now and then in many people with diabetes. Both forms of diabetes ultimately cause high blood sugar, a condition called hyperglycemia. Vitamin K is necessary for the blood clotting in the event of severe wounds and therefore helps to prevent the loss of blood. The body attempts to eliminate the surplus blood glucose by eliminating it in the urine. It will help with blood sugar control, fat loss, and higher blood pressure.
Regular exercise is especially critical for those who have diabetes. There are lots of things you should do to help control your diabetes. They would like to look like they’re doing an excellent job controlling their blood sugar. While pregnant, there are just a few methods of making certain your baby is healthy.
Most patients with diabetes must have a residence blood monitoring kit. Another test known as the oral glucose tolerance test could be performed instead. The regular utilization of this medicine can cause kidney issues. Antacids that have magnesium or aluminium needs to be taken a number of hours prior to or a couple of hours after taking the medication. It can be taken by adults and kids over the age of a couple of years old.
Currently, flaxseed are available commonly in a type of food additives and soft gel capsule. Generally Vitamins can be found in a similarity to capsules, tablets, syrups and injections. The major side effect, as such, is that as it may reduce blood sugar, some caution might be necessary if you take it with other agents, including herbs or pharmaceutical medications, which could lower blood glucose. Gradual decrease in Insulin dose in future.
The most recent research has indicated that the ovulation problem in women experiencing polycystic syndrome could be cured by metformin. Sometimes clomid together with metformin is utilized for ovulation and pregnancy. When associated with certain different abnormalities, it’s also known as the metabolic syndrome.
Acute complications (hypoglycemia, ketoacidosis or nonketotic hyperosmolar coma) might occur whether the disease isn’t adequately controlled. It’s therefore essential to control the diabetes also as the rest of the risk factors for artery diseases that bring about heart attack and stroke. High rates of ketones can be exceedingly harmful. Afterwards, studies reveal that flaxseed has numerous health benefits and there are specific minerals and vitamins found within the plant that are essential for the entire body’s proper functioning.
It is helpful to become rid of Scurvy disease. In addition, They are helpful for a lot of conditions like asthma and arthritis. It is very important to take it exactly as it is often prescribed to prevent any unforeseen complications. It is really an antihistamine which is used in treating hay fever and other allergies.
There are only three areas which are important that you understand in diabetes. For those who have heart issues, you must probably receive a referral to a cardiologist. If you eat too much as you are taking metformin, obviously, you may gain weight.
It is not utilised to stop a migraine that is already triggered. They’re able to reduce inflammative conditions like redness, swelling and soreness. Fexofenadine doesn’t easily traverse the blood-brain barrier, and because of this isn’t going to induce sleepiness. On the opposite hand it can also cause constipation.
Pre-diabetes is a typical condition associated with diabetes. Type 2 diabetes is easily the most common type of the disease. Diabetes is a disease where the body doesn’t produce or properly utilize insulin. Weight gain, liver issue and risk of creating anemia are other problems related to the use of Thiazolidinediones.
Glipizide (Glipizide) – instructions for use, description of the pharmacological action, indications for use, dosage and mode of administration, contraindications, side effects
Code CAS: 29094 – 61 – 9
Characteristics: White odorless powder. Insoluble in water and alcohol, but soluble in NaOH solution at a concentration of 0.1 mol / l and good solubility ; dimethylformamide.
Mode of action
Pharmacology: Mode of action – hypoglycemic. It stimulates the release of insulin from the functional – active beta – cells of the pancreas. It lowers the level of glycated hemoglobin and fasting glucose concentrations in patients with moderate and severe forms of insulin dependent diabetes mellitus. Postpischevuyu reduces hyperglycemia, increase glucose tolerance and clearance of free liquid (slightly). Insulinotropic response develops within 30 min after oral administration, the duration of action after a single reception is 24 hours. No effect on the lipid profile of blood plasma.
In the experiments on rats and mice at doses in excess of 75 times MRDC not induce carcinogenesis and has no effect on fertility (rats). Studies performed in bacteria, and in vivo, showed no mutagenic properties.
A high-speed form is absorbed rapidly and completely. Food does not affect the total absorption, but it slows down for 40 minutes. C_max defined in 1 – 3 hours after a single dose. T_1 / 2 is 2 – 4 hours after oral slow form will appear in the blood after 2 -. 3 hours, C_max reached after 6 -. 12 hours Associated with the plasma protein by 98 – 99%. The volume of distribution after the on / in ; 11 liters, the average T_1 / 2 ; 2 -. The Cl 5 hours after a single intravenouslytroduction of 3 l / h. Biotransformiroetsa in the liver (during the initial passage ; slightly). Less than 10% is excreted unchanged in the urine and faeces, approximately 90% is excreted as metabolites in the urine (80%) and faeces (10%).
Indications for use
Application: Type 2 diabetes mellitus in the absence of the effect of a low calorie diet, adequate exercise, etc .; diabetic microangiopathy.
Contraindications: Hypersensitivity, diabetic ketoacidosis, diabetic coma, juvenile diabetes, type 1, fever, trauma, surgery, pregnancy, breast-feeding.
Restrictions to application: Diseases of the digestive tract, liver and kidney (continuous monitoring of blood glucose levels), children’s age (efficacy and safety of use in children have not been established).
Pregnancy and lactation: Contraindicated. If use during pregnancy is required for cancellation 1 month before the expected birth and the transition to insulin therapy. At the time of treatment should stop breastfeeding.
Side effects: to a slow form of glipizide:
From the nervous system and sensory organs: dizziness, headache, insomnia, somnolence, anxiety, depression, confusion, gait disturbance, paresthesia, hypersthesia, blurred vision, eye pain, conjunctivitis, bleeding in the retina
On the sides of cardio – vascular system and blood (blood, hemostasis): syncope, arrhythmia, hypertension, feeling the tides.
From a metabolism:. Hypoglycemia
From the digestive tract: anorexia, nausea, vomiting, feeling of heaviness in the epigastric region, dyspepsia, constipation, blood in the stool.
For the skin: rash, hives, itching,.
From the respiratory system: rhinitis, pharyngitis, dyspnea.
With the genitourinary system: dysuria, loss of libido.
Others: thirst, tremor, peripheral edema, nonlocalized pain throughout the body, arthralgia, myalgia, convulsions, sweating.
For a quick form glipizide:
From the nervous system and sensory organs: headache, dizziness, drowsiness.
On the part of cardio – vascular system and blood (blood, hemostasis: leukopenia, agranulocytosis, thrombocytopenia, pancytopenia, hemolytic or aplastic anemia.
From a metabolism: diabetes insipidus, hyponatremia, porphyrin disease.
From the digestive tract: nausea, vomiting, epigastric pain, constipation, cholestatic hepatitis (yellow color of the skin and sclera, discoloration of stools and dark urine, pain in the right upper quadrant).
For the skin: erythema, maculo – papular rash, urticaria, photosensitivity.
Others: increased concentrations of LDH, alkaline phosphatase, indirect bilirubin.
Interaction: Efficacy weaken mineral – and glucocorticoids, amphetamines, anticonvulsants (hydantoin derivatives), asparaginase, baclofen, calcium antagonists, carbonic anhydrase inhibitors (acetazolamide), chlorthalidone, oral contraceptives, epinephrine, ethacrynic acid, furosemide, glucagon, salicylates thiazide diuretics, thyroid hormones, triamterene and others. drugs, causing hyperglycemia. Anabolic steroids and androgens increase the hypoglycemic activity. Indirect anticoagulants, NSAIDs, chloramphenicol, clofibrate, guanethidine, MAO inhibitors, probenecid, sulfonamides, rifampicin increase the concentration of the free fraction of blood (due to displacement from its association with plasma proteins) and accelerate the biotransformation. Ketoconazole, miconazole, sulfinpyrazone and enhance inactivation block hypoglycemia. Against the background of alcohol may develop disulfiramopodobnyh syndrome (abdominal pain, nausea, vomiting, headache). Antithyroid and myelotoxic drugs increases the risk of agranulocytosis; the latest addition ; thrombocytopenia.
Treatment: removal of the drug, taking glucose and / or change of diet with the necessary monitoring of blood glucose; in severe hypoglycemia (coma, epileptiform seizures) ; immediate hospitalization, the introduction of 50% glucose solution / jet with simultaneous infusion (/ drip) 10% glucose solution for blood glucose concentrations above 5.5 mmol / L; glucose monitoring requires further 1 – 2 days after patient release of coma. Dialysis is ineffective.
Dosage and method of administration
Dosage and administration: Inside before or during a meal. Rapid-form ; 5 mg before breakfast, with no effect for several days the dose is increased by 2.5 – 5 mg (required constant monitoring of blood glucose concentration); the maximum single dose of ; 15 mg, the maximum daily dose of ; 40 mg. Doses above 15 mg administered in divided doses. Against the background of liver, kidney, and elderly patients ; 2.5 mg. Slow form ; 5 mg at breakfast. To monitor the effectiveness of a slow form 1 time in 3 months determine the level of glycosylated hemoglobin. If after three months the effect is insufficient, increasing the dose to 10 mg or 20 mg (maximum daily dose).
Caution: Be wary appoint elderly, debilitated, and malnourished patients and patients with adrenal and pituitary insufficiency (in order to avoid hypoglycemic reactions starting and maintenance doses should not be high).
Other medications and drugs used together and / or instead of the “Glipizide (Glipizide)” in the treatment and / or prevention of the following diseases.