Last Updated on February 19, 2017 by Dr.Derek Fhisher
Most popular brand: Imuran
Active ingredient: Azathioprine
Available dosage forms: 50, 25 mg
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Azathioprine general information
Besides these azathioprine might cause headache and tummy upset. Currently there isn’t any cure for Myositis, but it might be controlled with medications, including Prednisone, and immunosuppressants, for example Methotrexate and Azathioprine. Drugs for example vaccines and allopurinol ought to be avoided while taking azathioprine. Fortunately, most patients have the ability to control the issue with the correct medications.
Irritability is among the absolute most generally symptoms in children. Some patients may well not show any symptoms whatsoever. Even though most cases of the disease occurs in the ileum and also the colon. Symptoms include cramping within the abdominal region and frequent, loose bowel movements.
Taking prednisone together with alcohol can cause severe interactions. Side effects may also occur because of drug interactions. Thirdly, it shouldn’t be given along with aspirin and other drugs that bring about interaction effects. The doses would need to be increased for a brief period followed by gradual decrease in dosage.
Prednisone is really a synthetic corticosteroid which is used for remedying certain health conditions in humans in addition to animals. Prolonged utilization of prednisone can affect the entire body’s ability to create natural corticosteroids, thereby increasing the odds of drug dependence. There’s a risk of creating osteoporosis and rheumatoid arthritis over the plan of treatment. Don’t forget, that prednisolone can be considered a life-saver oftentimes if taken exactly as prescribed while the doctor is well-informed of your healthcare history.
Also called hyperadrenocorticism, Cushing’s disease is among the most serious unwanted side effects of prednisone. In canines, prednisone is often prescribed for healing autoimmune conditions. It is usually used for remedying canine infections due to pathogens or allergens. Prolonged utilization of prednisone can lead to pain as well as inflammation within the joints, thereby making it tough for the dog to walk.
Prednisone is put under a division of drugs called corticosteroids. Prednisone resembles cortisol. Prednisone is generated by dehydrogenation of cortisone. The medicine will not produce instant consequences.
Prednisone dosage for dogs really depends on the condition that’s being treated. Although prednisone is a powerful drug, it must be administered carefully. This is among the most frequent and dreaded side-effects of consuming prednisolone. You may experience ulceration within the mouth.
The remainder of the post let’s you know about the correct utilization of this drug in canines, its common unwanted side effects, in addition to a few precautions you should exercise as a pet owner. Consequently, it is very important to monitor any abnormal behavior within the dog. Their interaction can affect a number of people within an adverse manner, and not affect others whatsoever. This might affect the friends or relatives of that particular individual too.
Researchers believe beer consumption results in gout due to the high purine content. This causes accumulation of glucose within the blood, which then results in diabetes. The side effects might be severe, hence it is best to prevent the consumption altogether.
It is essential to be aware that a little volume of alcohol could possibly be introduced, if and as soon as the doctor is totally certain about how your system is really in the position to tolerate the consumption. In any case, in the event the patient really has been a drinker, the physician will prescribe several tests to fix the degree of liver deterioration, if any, as a result of excess alcohol consumption. The dose is frequently adjusted taking into regard the answer to the therapy. Its effects could be observed in a couple hours.
When prednisone is provided alone, the objective is mainly symptom management, plus it doesn’t boost the duration of survival. That’s the reason why, drugs like prednisone are tapered off rather than stopping abruptly, so the body has plenty of time to recuperate and resume its regular formation of cortisol. In several cases, cutting back the dose might be needed, but ought to be done strictly under the doctor’s guidance. The affected men and women have to follow the directions of the doctor about the dosage religiously.
Some could complain about increased hair growth on the whole body, bed wetting during the night, headaches, drop in bone density, etc.. As baldness generally leads to baldness if untreated, it is advisable to reduce hair thinning including re grow the hair too. It’s also now known to affect hair development and loss. To locate the root cause of baldness, it is best to visit a doctor.
Canine diabetes happens when the body cannot produce enough insulin, or when the body isn’t able enough to absorb the insulin that’s being produced. In addition, it may interact with several other routine medications and can lead to health complications. The danger of secondary infections brought on by viruses or fungi could also increase with long-term glucocorticoid therapy. Its prolonged use leads to a weak immune system which then increases the frequency or seriousness of infections.
As an overall rule it’s accepted that exercise is great for health. Because of this, it is better to prevent the consumption. They could diminish the energy level within your body including your resistance power.
Azathioprine (Imuran), instructions for use
International name. Azathioprin.
Structure and Composition The active substance -. Azathioprine. Tablets containing 50 mg azathioprine in a package of 100 tablets, ampoules for injection containing the equivalent of 50 mg of azathioprine sodium salt, lyophilized under cooling in an individual package.
Indications for receiving azathioprine. Azathioprine is indicated for the treatment of patients who undergo organ Azathioprine transplantation has a significant therapeutic effect for the following diseases chronic active hepatitis, severe rheumatoid arthritis, systemic lupus erythematosus, dermatomyositis, pemphigus vulgaris , periarteritis nodosa, acquired hemolytic anemia, idiopathic thrombocytopenic purpura, pyoderma gangrenosum.
Azathioprine is also used in the following conditions: 1) When the disease is not curable one corticosteroid; 2) In diseases amenable to treatment with corticosteroids at the doses that cause severe adverse reactions, if necessary, reduce the need for steroid medications; 3) In cases where the use of corticosteroids is contraindicated. In the treatment of pemphigus vulgaris and rheumatoid arthritis Azathioprine exhibit significant therapeutic activity without corticosteroids. In other testimony, or in cases where the use of azathioprine in this disease is not permitted officially, it must be regarded as experimental. The risk associated with the use of azathioprine should correlate with the severity of the patient’s condition and the possible therapeutic effect
Dosage and method of use. is set individually, depending on the nosology and severity of the disease, the dosage of other drugs (such as prednisone), appointed at the same time imuranom, haematological tolerance.
Adults and children. Transplantation. Usually assigned a loading dose to 5 mg / kg orally, followed by a maintenance dose of 1 – 4 mg / kg / day orally (depending on the clinical condition and hematologic tolerance). If oral administration is not possible, a maintenance dose of 1 – 2, 5 mg / kg / day may be administered intravenously. Imuranom treatment in the absence of contraindications can be performed for an unlimited time may sometimes be necessary only very low doses. There is a significant risk of graft rejection in a few weeks after stopping treatment, even if treatment is continued for a number of years.
Other diseases. The dosage and duration of treatment varies depending on the disease, its severity and the clinical effect achieved. The clinical effect may not appear for several days or even a few weeks after starting treatment. If within 3 months of the patient’s condition does not improve, it is necessary to reconsider the advisability of appointing azathioprine. For the treatment of many diseases is the initial oral dose of 2 – 2, 5 mg / kg / day, it should be reduced in the event of hematologic and other complications. In chronic active hepatitis administered 1 – 1 5 g / kg / day. In rheumatoid arthritis, may be less effective dose. The use of intravenous injections (just in transplantations). The contents of each vial should be dissolved in 5 – 15 ml of water for injection. Preparation of the solution should be carried out immediately prior to use. Unused solution was stored at 5 degrees C to 5 days at room temperature – 24 hours. Data on the compatibility of azathioprine with other solutions for intravenous injection absent. When you remove the drug dose should be reduced gradually.
The side effects. The main side effect of azathioprine is a dose-related, generally reversible suppression of bone marrow function, manifested in leukopenia, thrombocytopenia, and, rarely, anemia. Hematological toxicity of the drug is also reflected in the development of megaloblastic erythropoiesis and macrocytosis. Hematological toxicity of azathioprine is most often at the beginning of treatment, but later provided data on the development of leukopenia and anemia, which confirms the need for continuous hematological monitoring even during prolonged stable treatment. Data on gastrointestinal intolerance to azathioprine orally vary. It is mainly manifested by nausea, anorexia, vomiting, sometimes. In some cases, these phenomena are due to dose; After a short break, the drug may be renewed at lower doses. The drug, if possible, should be taken with food. There is evidence of other, more serious gastrointestinal complications Pancreatitis is more common in transplant recipients and patients with intestinal granulomatosis. Gastrointestinal ulcers, intestinal haemorrhage, necrosis and perforation of the intestine are observed only after transplantation may have caused their occurrence is the simultaneous treatment of steroids In some cases Azathioprine can cause dose-dependent, reversible toxic cholestatic liver disease. In such cases, stop taking the drug. There is evidence of different possibly allergic, reaction. Rare complications occurred following drug fever, skin rash, myalgia and arthralgia There are also isolated reports of complications, presumably related to the taking azathioprine, such as acute renal failure, hemolytic anemia, acute lung disease and unexplained meningeal reactions Application of pregnancy and lactation. It is necessary to take into account the potential teratogenicity of azathioprine. Although its teratogenic properties have been proved in laboratory animals, a person’s risk of their occurrence is low. There is no doubt that azathioprine and its metabolites cross the placenta. There temporarily impaired immune function after exposure to azathioprine in combination with prednisone in utero. Long-term consequences of these properties of azathioprine are not known, but many children whose mothers during pregnancy received the drug, currently safely reached the age of ten. In the breast milk of women treated with Imuran, the drug has not been found.
Contraindications for use of azathioprine. : Hypersensitivity to the drug.
Caution. The patient should be under the supervision of an appropriate during therapy. There is a potential risk when using azathioprine. It should be used only if there is adequate opportunity for the patient observation to detect toxic effects throughout the treatment period. During the first 8 weeks of treatment Imuranom weekly or more often (using high-dose or presence of severe renal and / or hepatic – cell deficiency) should do a complete blood count, including platelet count of frequency of blood tests can then be reduced. Azathioprine may be used for a long time if the patient tolerates the drug. Cancel effective dose in some cases, such as systemic lupus erythematosus, nephritis accompanied may cause severe relapse. In other diseases such as rheumatoid arthritis and certain diseases of the blood system, the treatment may be terminated after a certain period of time without a negative effect. Discontinuation of treatment is always carried out slowly and under constant surveillance. If you have severely impaired renal or liver function closely monitored since the beginning of treatment should be carried out, that is to may be necessary to reduce the dose of azathioprine.
Infections. The development of severe secondary infections, which are often redkovstrechayuschiesya pathogens microorganisms poses a risk during immunosuppressive therapy. These infections are more common in transplant recipients than in patients taking Azathioprine in connection with other diseases.
The mutagenicity. Azathioprine is potentially mutagenic and causes chromosomal abnormalities in humans. The clinical significance of these data is unclear, t. To. The damage is obviously reversible on discontinuation of the drug.
The impact on fertility. Azathioprine does not have any – any inhibitory effect on fertility in women or men Suppression ability to bear children with chronic uremia is usually reversible after transplantation and its accompanying treatment with azathioprine.
carcinogens. In transplant recipients, an increase in the incidence of malignant tumors, especially the epithelial and lymphoreticular. Skin tumors in transplant recipients are mainly developing on the areas of skin exposed to sunlight. Patients should be warned about the inadmissibility of prolonged exposure to the sun, they should be regularly carried out inspection of the skin. However, no definitive data on the increase in the incidence of tumors in patients treated with azathioprine. In these patients, the risk of tumor is less than the risk in the treatment of certain diseases other drugs There is evidence of a small number of cases, evidence of another character of the development of tumors in non-transplant. Tumors develop less often have higher latency and occur mainly after long-term continuous treatment; they are not only exceptionally lymphoreticular, but also tend to develop in patients receiving both drugs alkylating
Interact with other drugs. In an application zilorika (allopurinol) Imuranom the last dose should be reduced to 1/4 the normal dose. Azathioprine should be used cautiously in patients who are receiving or have recently received other drugs that suppress bone marrow function Azathioprine is an antagonist of non-depolarizing muscle relaxants such as curare, d – tubocurarine and pancuronium. Experimental data confirm that azathioprine may enhance nervous – muscular blockade caused by succinylcholine and reduce the blockage caused by the d – tubocurarine.
overdose. It is necessary to carry out the symptomatic treatment. Azathioprine is removed by dialysis, however, in severe cases can be applied dialysis.
Storage. The tablets stored at temperatures below 35 ° C and in a dry, dark place Ampoules for injection stored at temperatures below 25 ° C in a dark place
Manufacturer of. WELLCOME, United Kingdom.
Use of the drug azathioprine only on prescription, instructions are given for reference!