Last Updated on February 19, 2017 by Dr.Derek Fhisher
Most popular brand: Lamprene
Active ingredient: Clofazimine
Available dosage forms: 50 mg
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Clofazimine general information
Clofazimine also appears to have anti-inflammatory action to lessen the swelling and pain associated with leprosy. Acquired ichthyosis is just a disorder clinically and histologically much like ichthyosis vulgaris. Clofazimine crosses the placenta, as well as skin discolouration was seen in neonates. Clofazimine capsules are employed to treat leprosy. Clofazimine can be found as a 50mg capsule. Acquired ichthyosis usually appears in adulthood.
The drug comes in capsules which include a clofazimine suspension in oil. Employing this medicine with any of these medicines is mainly not recommended, but might be needed in some instances. The existence of other medical problems might affect the use of the medicine. In severe cases they might prescribe oral retinoids for example acitretin or isotretinoin. Additionally, Clofazimine would be created available under special circumstances to be used in treating multi-drug resistant tuberculosis. The utmost dosage ought to be used from the beginning and ought not to be decreased during lepra reactions.
Inform your doctor in case you are pregnant or intend on becoming pregnant. Call your physician for medical advice regarding side effects. Don’t take your medicine more frequently than directed. Don’t skip doses or quit your medicine early. When it is almost time for your subsequent dose, take just that dose. In the event your dose differs, don’t change it unless your own doctor orders you to achieve that.
Potential dangers of clofazimine while pregnant and breastfeeding needs to be weighed. Special care might be needed. Keep away from the reach of children.
It could have a role in a few autoimmune diseases. It could appear before or following the diagnosis of the systemic condition. Consequently, synergy needs to be tested, rather than assumed, before treatment. It’s quite slowly eliminated within the faeces using a half-life of abut 70 days. It’s been hypothesized the depression was a result of the chronic skin discoloration. Side effects consist of dry and flaky epidermis, nausea, abdominal pain and discolouration of the epidermis, retina, cornea and urine.
Clofazimine is presently registered to be used in leprosy only, even though it’s also used in the treatment of multidrug-resistant tuberculosis and, sometimes, NTM. Clofazimine ought to be not be utilized in these patients. Get rid of any unused medicine following the expiration date. In such cases, your own doctor may want to alter the dose, or alternative precautions might be necessary. If you are taking this medicine, it’s especially important your healthcare professional know if you’re taking any one of the medicines given below.
Multidrug therapy is crucial to prevent the growth of drug resistance. This finding doesn’t support a major role for Mycobacterium avium subspecies paratuberculosis within the pathogenesis of Crohn’s disease in a clear majority of patients. For reasons which aren’t well documented, clofazimine wasn’t advanced for treating human tuberculosis but was utilized for treating leprosy and later, unsuccessfully, for healing Mycobacterium avium complex infection in patients with AIDS (3, 4). 7 out of 22 patients could reduce different immunosuppressants including cyclosporine A. This information includes only the typical doses of the medicine. Though the drug is effective within the management of leprosy reactions due to the anti-inflammatory activity, the mechanism causing the cessation of inflammation isn’t well understood.
The FDA categorizes medications predicated on safety to be used while pregnant. Clofazimine also passes into breast milk leading to skin discolouration within the infant. Speak with your pediatrician concerning the use of the medicine in children. Weigh the possible benefits against the possible risks before taking this medication whilst breastfeeding.
The argument they’ve made is in an alternative population in patients using a different condition which they didn’t enjoy the drug,” explained Field. As the association wasn’t recognized in the beginning, most patients continued to obtain rifabutin after the beginning of uveitis. Lastly, the comparison between both doses of rifabutin has to be interpreted cautiously, as the patients weren’t randomly assigned to receive 1 dose or the other, along with the doses were given about 1 year apart. It doesn’t just provides a positive reply but in addition demonstrates the contribution of clofazimine was obtained with no apparent injury to the mice. Right now, monotherapy with an acceptable antileprosy drug may be instituted. The BreslowDay statistic26 was used to rate the homogeneity of the therapy effect prior to and following the reduction within the rifabutin dose.
The pharmacological action. Protivoleprozoyny drug. It inhibits the growth of Mycobacterium leprae (the bacteria that cause leprosy). It is active against pathogens that are resistant (resistant) to other drugs. Also has anti-inflammatory properties and can be used for the treatment of lepra reactions observed in the treatment by other means; in this case, may reduce the dose of glucocorticoids (hormones of the adrenal cortex or their synthetic analogues), until their complete abolition.
Indications for use Leprosy (prevention of secondary resistance / stability / to drugs sulfone series and leprosy reactions at lepromatous, borderline, and borderline – lepromatous types of leprosy).. Treatment lepromatous, borderline, and borderline – lepromatous types of leprosy, resistant to sulfone drugs (eg, diafenilsulfonom). Treatment of leprosy reactions (eg, erythema nodosum leprosy).
Dosage and administration. Before you assign patient drug to determine sensitivity to the hair that caused the disease in this patient. Clofazimine is used in combination with rifampicin and diafenilsulfonom. Scheme of use in the treatment polibatsillyarnoy leprosy: clofazimine – 300 mg 1 time per month under the control and 50 mg 1 time per day as a maintenance therapy, rifampicin – 600 mg 1 time per month under the control of, diafenilsulfonom – 100 mg 1 time per day as maintenance therapy. The course of treatment – at least 2 years. When nodal erythema dose of clofazimine should be increased to 300 mg per day (no more than 3 months).
Children prescribed drugs according to the following scheme: clofazimine – 5 mg / kg body weight one time per month under the control and 1 mg / kg “! once a day as a maintenance therapy, rifashshiin – 10 mg / kg 1 month raz.V under control diafenilsulfonom – 1.5 mg / kg, 1 time per day as maintenance therapy.
The capsules should be taken with food or drink milk.
To prevent the development of resistance of Mycobacterium leprae to clofazimine, it is useful to combine with solyusulfonom.
With care prescribe a drug to patients with impaired liver and kidney function and / or an indication of liver and kidney disease in history (history). In these cases, as well as long-term use of the drug every 3 months is necessary to monitor the common blood and urine tests, biochemical analysis of blood.
Side effect. Colouring in red or dark brown color and leprosy lesions (especially in areas exposed to light, in patients with fair skin) as well as hair coloring, the conjunctiva (the outer membranes of the eyes) , tears, sweat, sputum, urine, feces. Dry skin, ichthyosis (scaly thickening of large areas of skin), pruritus, photosensitivity (increased sensitivity of the skin to sunlight), aknepodobnye (acneform) rash, nonspecific rash. Nausea, vomiting, abdominal pain, diarrhea, loss of appetite, weight loss – these side effects observed with concomitant diseases of the gastro – intestinal tract, such as amoebiasis (infectious diseases caused by amoeba Entamoebahistolytica, characterized by chronic inflammation of the colon with the formation of ulcers) bacterial intestinal infections; and when receiving high doses – over 300 mg / day. for more than 3 months.
When you are in the treatment of gastro – intestinal disorders, it is necessary to reduce the daily dose or increase the interval between doses of the drug. Lepra reactions are rarely observed during treatment with clofazimine, can be eliminated by a temporary increase in the dose of the drug.
Contra. It should be possible to refrain from appointment clofazimine in patients with frequent abdominal pain and diarrhea (diarrhea). Appointment in the first trimester of pregnancy should be carried out only under strict indications.
Release Form. The capsules of 0.05 and 0.1 g in a package of 100 and 1,000.
Storage. : List B. In dry, dark place.
This information is not a guide to self-treat.
Necessary to consult a doctor.