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Most popular brand: Pepcid
Active ingredient: Famotidine
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Famotidine (Famotidine): instruction, and the use of a formula

Code CAS

Characteristics of Famotidine substances

White or pale – yellow crystalline powder. It is soluble in acetic acid, weak ; in methanol and water, practically insoluble in ethanol.

Pharmacology

Mode of action -. Protivoyazvennoe

It blocks histamine H ₂ – receptors inhibits basal and stimulated secretion of hydrochloric acid; inhibits the activity of pepsin.

From the digestive tract is not fully absorbed, bioavailability of 40 – 45%, increases under the influence of food and decreases with the use of antacids. Binding to plasma proteins ; 15 – 20%. C _max is achieved within 1 – 3 hours 30 – 35% is metabolized in the liver with the formation of S – oxide and excreted by the kidneys by glomerular filtration and tubular secretion.. 25 – 30% of the dose ingested and 65 – 70% imposed on / in is detected in the urine in unchanged form. T _1/2 from plasma ; 2,5 – 3 hours in patients with severe renal insufficiency (creatinine Cl < 10 ml / min) may be increased to 20 hours (dose adjustment is required). Passes through the placenta and is excreted in breast milk.

Once inside the action begins at 1 hour, reaches a maximum for 3 hours and lasts 10 – 12 h under / in the maximum effect is 30 minutes.. A single dose of (10 mg and 20) inhibit the secretion of 10 – 12 h.

Application of the substance famotidine

Treatment and prevention of relapse of gastric ulcer and duodenal ulcer; symptomatic treatment and prevention of gastric and duodenal ulcers (associated with taking NSAIDs stress, postoperative.); erosive gastro reflux – esophagitis, Zollinger syndrome – Ellison syndrome, bleeding from the upper gastrointestinal tract (in the complex treatment) and prevention of recurrent bleeding from the upper gastrointestinal tract. systemic mastocytosis, multiple endocrine adenomatosis, prevent aspiration of gastric juice during general anesthesia (Mendelson’s syndrome). Functional dyspepsia associated with increased gastric secretion. Symptomatic treatment of dyspepsia associated with acidity of gastric juice (including heartburn, acid regurgitation).

Contraindications

Hypersensitivity, pregnancy, breast-feeding.

Restrictions on the use

Liver cirrhosis with hepatic encephalopathy, children’s age.

Application of pregnancy and breastfeeding

Category effects on the fetus by FDA ; B.

Side effects of substance famotidine

From the digestive tract: dryness of the oral mucosa, loss of appetite, nausea, vomiting, abdominal pain, increased liver transaminases, constipation, diarrhea, jaundice; hepatocellular, cholestatic or mixed hepatitis, acute pancreatitis.

From the cardio – vascular system and blood (blood, hemostasis): decrease in blood pressure. bradycardia, AV block, arrhythmia, vasculitis, neutropenia, leukopenia, thrombocytopenia, hemolytic anemia, agranulocytosis, pancytopenia; when administered parenterally ; asystole.

From the nervous system and sensory organs: headache, asthenia, somnolence, insomnia, fatigue, anxiety, depression, anxiety, psychosis, dizziness, confusion, hallucinations, hyperthermia, ringing in the ears.

With the genitourinary system: with prolonged high doses of ; lower potency and libido.

From the musculo – skeletal system: arthralgia, myalgia.

Allergic reactions: hives, skin rash, itching, bronchospasm, angioedema, mnogomorfnaya erythema, exfoliative dermatitis, Stevens – Johnson syndrome, toxic epidermal necrolysis, anaphylaxis.

Other: bronchospasm, dry skin, alopecia, gynecomastia; Local reactions ; irritation at the injection site.

Interaction

At the same time taking famotidine and ketoconazole may decrease the absorption of ketoconazole. In the case of famotidine with antacids the interval between their intake should be at least 1 – 2 hours.

Overdose

Symptoms: aggravation of side effects.

Treatment: gastric lavage, symptomatic and supportive therapy.

Dosing and Administration

Inside, intravenously. Inside, acute gastric ulcer and duodenal ulcers, 40 mg at night or 20 mg 2 times / day (morning and evening), the daily dose may, if necessary, be increased to 80 – 160 mg, the duration of the course ; 4 – 8 weeks; for the prevention of exacerbations ; 1 to 20 mg once a day at night. When reflux – esophagitis ; 20 – 40 mg 2 times a day for 6 – 12 weeks. Zollinger – Ellison ; the dose and duration of treatment is determined individually.

When heartburn or other symptoms of dyspepsia ; 10 mg (1 tab.); should not be used more than 2 tablets. per day.

B / (bolus or infusion), the usual dose ; 20 mg every 12 hours; single dose not exceed 20 mg. The syndrome Zollinger – Ellison initial dose ; 20 mg every 6 hours, subsequently adjust the dose; for the prevention of aspiration of gastric contents prior to general anesthesia: 20 mg before surgery or at least 2 hours prior to the start.

Precautions substance famotidine

Patients with renal impairment (Cl creatinine less than 30 mL / min) daily dose should be reduced to 20 mg. Children drug is not recommended.

In the treatment of gastric ulcer and duodenal ulcers should be excluded in a patient with malignant tumor (biopsy study of ulcer area). To use caution in the human liver.