Last Updated on February 19, 2017 by Dr.Derek Fhisher
Most popular brand: Pepcid
Active ingredient: Famotidine
Available dosage forms: 20, 40 mg
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Famotidine general information
Paula is a great teacher. You can also read a number of them below. Please get in touch with us for availability. In case it’s almost time for your subsequent dose, forget the missed dose and return to your own usual dosing timetable. To stop recurrence after healing trim the dose to a 20mg tablet during the night.
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Step one is to keep up a nutritious weight. Increase in gastrin production can also lead to high rates of calcium within the blood (Hypercalcemia) which can likewise cause GERD. Using some non-steroidal anti-inflammatory drugs like prednisolone. It is thought that obstructive sleep apnea may also cause GERD. Therefore, the truth is the fact that surgical procedures have several complications and significant failure rates and don’t always cure gastroesophageal reflux. Sometimes, the underlying cause might not be found.
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Famotidine (Famotidine): instruction, and the use of a formula
Characteristics of Famotidine substances
White or pale – yellow crystalline powder. It is soluble in acetic acid, weak ; in methanol and water, practically insoluble in ethanol.
Mode of action -. Protivoyazvennoe
It blocks histamine H 2 – receptors inhibits basal and stimulated secretion of hydrochloric acid; inhibits the activity of pepsin.
From the digestive tract is not fully absorbed, bioavailability of 40 – 45%, increases under the influence of food and decreases with the use of antacids. Binding to plasma proteins ; 15 – 20%. C max is achieved within 1 – 3 hours 30 – 35% is metabolized in the liver with the formation of S – oxide and excreted by the kidneys by glomerular filtration and tubular secretion.. 25 – 30% of the dose ingested and 65 – 70% imposed on / in is detected in the urine in unchanged form. T 1/2 from plasma ; 2,5 – 3 hours in patients with severe renal insufficiency (creatinine Cl < 10 ml / min) may be increased to 20 hours (dose adjustment is required). Passes through the placenta and is excreted in breast milk.
Once inside the action begins at 1 hour, reaches a maximum for 3 hours and lasts 10 – 12 h under / in the maximum effect is 30 minutes.. A single dose of (10 mg and 20) inhibit the secretion of 10 – 12 h.
Application of the substance famotidine
Treatment and prevention of relapse of gastric ulcer and duodenal ulcer; symptomatic treatment and prevention of gastric and duodenal ulcers (associated with taking NSAIDs stress, postoperative.); erosive gastro reflux – esophagitis, Zollinger syndrome – Ellison syndrome, bleeding from the upper gastrointestinal tract (in the complex treatment) and prevention of recurrent bleeding from the upper gastrointestinal tract. systemic mastocytosis, multiple endocrine adenomatosis, prevent aspiration of gastric juice during general anesthesia (Mendelson’s syndrome). Functional dyspepsia associated with increased gastric secretion. Symptomatic treatment of dyspepsia associated with acidity of gastric juice (including heartburn, acid regurgitation).
Hypersensitivity, pregnancy, breast-feeding.
Restrictions on the use
Liver cirrhosis with hepatic encephalopathy, children’s age.
Application of pregnancy and breastfeeding
Category effects on the fetus by FDA ; B.
Side effects of substance famotidine
From the digestive tract: dryness of the oral mucosa, loss of appetite, nausea, vomiting, abdominal pain, increased liver transaminases, constipation, diarrhea, jaundice; hepatocellular, cholestatic or mixed hepatitis, acute pancreatitis.
From the cardio – vascular system and blood (blood, hemostasis): decrease in blood pressure. bradycardia, AV block, arrhythmia, vasculitis, neutropenia, leukopenia, thrombocytopenia, hemolytic anemia, agranulocytosis, pancytopenia; when administered parenterally ; asystole.
From the nervous system and sensory organs: headache, asthenia, somnolence, insomnia, fatigue, anxiety, depression, anxiety, psychosis, dizziness, confusion, hallucinations, hyperthermia, ringing in the ears.
With the genitourinary system: with prolonged high doses of ; lower potency and libido.
From the musculo – skeletal system: arthralgia, myalgia.
Allergic reactions: hives, skin rash, itching, bronchospasm, angioedema, mnogomorfnaya erythema, exfoliative dermatitis, Stevens – Johnson syndrome, toxic epidermal necrolysis, anaphylaxis.
Other: bronchospasm, dry skin, alopecia, gynecomastia; Local reactions ; irritation at the injection site.
At the same time taking famotidine and ketoconazole may decrease the absorption of ketoconazole. In the case of famotidine with antacids the interval between their intake should be at least 1 – 2 hours.
Symptoms: aggravation of side effects.
Treatment: gastric lavage, symptomatic and supportive therapy.
Dosing and Administration
Inside, intravenously. Inside, acute gastric ulcer and duodenal ulcers, 40 mg at night or 20 mg 2 times / day (morning and evening), the daily dose may, if necessary, be increased to 80 – 160 mg, the duration of the course ; 4 – 8 weeks; for the prevention of exacerbations ; 1 to 20 mg once a day at night. When reflux – esophagitis ; 20 – 40 mg 2 times a day for 6 – 12 weeks. Zollinger – Ellison ; the dose and duration of treatment is determined individually.
When heartburn or other symptoms of dyspepsia ; 10 mg (1 tab.); should not be used more than 2 tablets. per day.
B / (bolus or infusion), the usual dose ; 20 mg every 12 hours; single dose not exceed 20 mg. The syndrome Zollinger – Ellison initial dose ; 20 mg every 6 hours, subsequently adjust the dose; for the prevention of aspiration of gastric contents prior to general anesthesia: 20 mg before surgery or at least 2 hours prior to the start.
Precautions substance famotidine
Patients with renal impairment (Cl creatinine less than 30 mL / min) daily dose should be reduced to 20 mg. Children drug is not recommended.
In the treatment of gastric ulcer and duodenal ulcers should be excluded in a patient with malignant tumor (biopsy study of ulcer area). To use caution in the human liver.