Most popular brand: Artane
Active ingredient: Trihexyphenidyl
Available dosage forms: 2 mg
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Trihexyphenidyl general information
Dont diet to shake off excess weight or even to maintain your prior weight level while you’re pregnant. Sometimes medications and drugs can pep up your own metabolism resulting in weight loss. The body could possibly be experiencing some weight gain currently because it’s getting cleared of extra build-up within the colon and intestines. If you keep on a very natural weight-loss program, an affordable expectation once you have lost the water weight is about 1 to 2 pounds weekly. You’re well mindful of the substantial role muscle plays to burn calories, so should you wish to be lean and toned you’ll should build muscle to assist your body burn calories. In the event that you really just need some vitamin C, have a supplement or eat a real orange and find a number of the fiber to go along with it.
Fiber isn’t talked about much in regards to gaining weight. There are many of women who’ve also lost weight when taking it if they’ve adhered to a healthful diet and plenty of exercising. They don’t necessarily need to get rid of excess weight.
Outstanding liver function is completely essential to having the ability to reach natural weight reduction. It actually aids within the digestive process but in addition, it can stimulate appetite. To start with, it’s important to tone down the detoxification load on the liver. The liver is a rather commonly-overlooked generator of weight difficulties. The above mentioned information associated with fast metabolism is dependent on the general symptoms faced by many of the individuals with fast metabolism. These pancreatic enzymes are crucial for the right digestion and absorption of nutriments.
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You might not actually possess the stomach flu, but instead, a parasite or alternative infection you acquired during your travels. If so, then ask your physician to receive your thyroid tested. It’s only an issue of locating the suitable medication and workout routine. If at all possible, I advise avoiding alcohol and non-essential medications entirely for no less than a few weeks to provide the liver a chance to recover.
Soy becomes an essential ingredient in the Vegan diet too, replacing meat as a wellspring of protein. You have to eat lots of proteins to put on weight with equal variety of carbohydrates. PediaSure may serve as a nutritional supplement or even a sole wellspring of nutrition.
Analogues and price Trihexyphenidyl. Reviews and instructions for use
Trihexyphenidyl – antiparkinsonian agent. It has a strong central district – anticholinergic effects, and peripheral m – anticholinergic action. Central action helps to reduce or eliminate the movement disorders associated with extrapyramidal disorders.
When Parkinsonism reduces tremors, to a lesser extent, affects the rigidity and bradykinesia.
It has antispasmodic action, which is associated with anticholinergic activity and direct action miotropnym.
Comparative cost analogues
Registration number. LSR – 005076/09 – 260 609
Commercial product name. Trihexyphenidyl
International Non-Proprietary Name (INN). trihexyphenidyl
Dosage Form. Tablets
Ingredients. 1 tablet contains
The active substance . 2 mg trihexyphenidyl hydrochloride;
Excipients . sucrose (sugar), potato starch, povidone (polyvinylpyrrolidone, low molecular weight Medical M. 12600 ± 2700 m.), calcium stearate monohydrate, crospovidone (polyplasdone XL – 10).
Description. Tablets white, round biconvex.
Pharmacotherapeutic group:. holinoblokator central
Code ATX N04AA01
Refers to the number 1 list of potent substances PKKN.
antiparkinsonian agent. It has central and peripheral anticholinergic and muscle relaxant effects. The mechanism of action is based on competition with acetylcholine on the postsynaptic membrane. It reduces tremor, less effect on rigidity and hypokinesia. It has peripheral M – anticholinergic action: reduce salivation in less sweating and sebaceous gland secretion.
In the oral application Trihexyphenidyl is rapidly and completely absorbed from the digestive tract. The half-life of 5 – 10 hours. Trihexyphenidyl is highly lipotropic well pass through the blood-brain and placental barriers. Provided with breast milk. It is hydrolyzed under the influence of a nonspecific tissue esterases. Report the news: a small amount in an unmodified form, and the main part – in the form of metabolites.
Parkinsonism of various etiologies; movement disorders associated with lesions of the extrapyramidal system.
Hypersensitivity to any component of the drug, mechanical stenosis of gastro – intestinal tract, megacolon, angle-closure glaucoma, urinary retention, prostatic hyperplasia (with the presence of residual urine), pulmonary edema, dementia, children’s age (12 years), pregnancy, lactation.
Precautions . decompensated heart disease, kidney or liver disease, tachycardia, tachyarrhythmia, hypertension, psychosis, acute myocardial infarction, advanced age.
Dosing and Administration
Inside, before a meal or during a meal.
The initial dose – 0.5 – 1 mg / day. Gradually increase the dose of 1 – 2 mg every 3 – 5 days.
The usual maintenance dose – 6 – 10 mg per day, divided into 3 – 4 doses. In severe cases it may be necessary to increase the dose up to 12 – 16 mg, divided into 3 – 4 divided doses. The maximum single dose – 10 mg daily – 16 mg.
From the of the nervous system. headache, dizziness, irritability, delusions, hallucinations, fatigue, decreased concentration, psychoses.
Effects due to anticholinergic activity . dryness of the mouth, paresis of accommodation, increased intraocular pressure, constipation, urinary retention (including the prostate cancer), tachycardia, decreased sweating.
From the digestive system . nausea, vomiting.
Allergic reactions . skin rash.
Others . purulent parotitis (due to xerostomia), flushing of the skin, decreased muscle tone, possible development of drug dependence.
Large doses of trihexyphenidyl cause blockade postganglionic endings of the parasympathetic nervous system, poisoning the picture corresponds to the poisoning of atropine (mydriasis, dryness of the oral mucous membranes, tachycardia, atony bowel and biliary tract. Fever). Disorders of the central nervous system symptoms are expressed in mental and motor excitation may develop coma or paralysis of the respiratory center.
Chelation Therapy . there is no specific antidote. First Aid: gastric lavage, activated charcoal, symptomatic treatment.
In a joint application with the H1 – histamine blockers, phenothiazine derivatives, tricyclic antidepressants increase the expression of peripheral anticholinergic effects with chlorpromazine – possible decrease in its plasma concentrations.
Under the influence of reserpine antiparkinsonian effect of reduced trihexyphenidyl (dopamine depletion of the reserves of the central nervous system, activation of cholinergic neurons).
Levodopa increases the activity of anti-trihexyphenidyl. When applied with both drugs levodopa dosage should be reduced. Usually it is sufficient to 3 – trihexyphenidyl 6 mg per day, divided into two steps.
Under the influence of monoamine oxidase inhibitors may increase the anticholinergic action of anticholinergics used in parkinsonism.
In an application trihexyphenidyl reduced effect of sublingual nitrates used (due to dry mouth).
depressive effects of alcohol and drugs that affect the central nervous system may be enhanced when used with trigeksifenidilom.
During the period of treatment should refrain from driving motor vehicles and activities potentially hazardous activities that require high concentration and psychomotor speed reactions. Treatment should not be stopped suddenly. If you are taking the drug there is dryness of the mouth, it is desirable to take before eating, as otherwise it may appear nausea.
At the end of treatment or in case of alternative treatment trihexyphenidyl dose should be reduced gradually.
Patients older than 60 years is prescribed with extreme caution – the sensitivity to the drug – the possibility of deterioration of memory and thinking. When large doses of the drug or in patients with predisposing factors (atherosclerosis, advanced age or patients who previously appeared idiosyncrasy on what – or a drug) can appear mental disorders (unnatural increase in mood, agitation, irritability), vomiting or nausea . In these cases it is necessary to stop treatment. During long-term treatment severity of side effects caused by anticholinergic effect, decreases. It is necessary to periodically monitor eye pressure.
2 mg tablets. 10 tablets in blisters. 5 contour cell packages with instructions for use in a pile of cardboard.
The list of number 1 PKKN potent substances. In a dry, protected from light and the reach of children, at a temperature no higher than 25 ° C.
5 years. Do not use beyond the expiration date printed on the package.
The Federal State Unitary Enterprise “Moscow Endocrine Plant”), 109052, Moscow, ul. Novokhokhlovskaya, 25.
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