• Trihexyphenidyl general information

      • Analogues and price Trihexyphenidyl. Reviews and instructions for use

      • Indications

      • Comparative cost analogues

      • Trihexyphenidyl

      • Indications

      • Contraindications

      • Dosing and Administration

      • Side Effects

      • Overdose

      • Drug Interactions

      • Cautions

      • Release Form

      • Storage

      • Shelf Life

      • Terms holidays

      • Manufacturer

Artane Trihexyphenidyl 2 mg
Most popular brand: Artane
Active ingredient: Trihexyphenidyl
Available dosage forms: 2 mg
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Trihexyphenidyl general information

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Analogues and price Trihexyphenidyl. Reviews and instructions for use

Indications

Trihexyphenidyl – antiparkinsonian agent. It has a strong central district – anticholinergic effects, and peripheral m – anticholinergic action. Central action helps to reduce or eliminate the movement disorders associated with extrapyramidal disorders.

When Parkinsonism reduces tremors, to a lesser extent, affects the rigidity and bradykinesia.

It has antispasmodic action, which is associated with anticholinergic activity and direct action miotropnym.

Comparative cost analogues

Trihexyphenidyl

Registration number. LSR – 005076/09 – 260 609

Commercial product name. Trihexyphenidyl

International Non-Proprietary Name (INN). trihexyphenidyl

Dosage Form. Tablets

Ingredients. 1 tablet contains
The active substance . 2 mg trihexyphenidyl hydrochloride;
Excipients . sucrose (sugar), potato starch, povidone (polyvinylpyrrolidone, low molecular weight Medical M. 12600 ± 2700 m.), calcium stearate monohydrate, crospovidone (polyplasdone XL – 10).

Description. Tablets white, round biconvex.

Pharmacotherapeutic group:. holinoblokator central
Code ATX N04AA01

Pharmacological Properties
Refers to the number 1 list of potent substances PKKN.
Pharmacodynamics
antiparkinsonian agent. It has central and peripheral anticholinergic and muscle relaxant effects. The mechanism of action is based on competition with acetylcholine on the postsynaptic membrane. It reduces tremor, less effect on rigidity and hypokinesia. It has peripheral M – anticholinergic action: reduce salivation in less sweating and sebaceous gland secretion.

Pharmacokinetics
In the oral application Trihexyphenidyl is rapidly and completely absorbed from the digestive tract. The half-life of 5 – 10 hours. Trihexyphenidyl is highly lipotropic well pass through the blood-brain and placental barriers. Provided with breast milk. It is hydrolyzed under the influence of a nonspecific tissue esterases. Report the news: a small amount in an unmodified form, and the main part – in the form of metabolites.

Indications

Parkinsonism of various etiologies; movement disorders associated with lesions of the extrapyramidal system.

Contraindications

Hypersensitivity to any component of the drug, mechanical stenosis of gastro – intestinal tract, megacolon, angle-closure glaucoma, urinary retention, prostatic hyperplasia (with the presence of residual urine), pulmonary edema, dementia, children’s age (12 years), pregnancy, lactation.
Precautions . decompensated heart , kidney or liver disease, tachycardia, tachyarrhythmia, hypertension, psychosis, acute myocardial infarction, advanced age.

Dosing and Administration

Inside, before a meal or during a meal.
The initial dose – 0.5 – 1 mg / day. Gradually increase the dose of 1 – 2 mg every 3 – 5 days.
The usual maintenance dose – 6 – 10 mg per day, divided into 3 – 4 doses. In severe cases it may be necessary to increase the dose up to 12 – 16 mg, divided into 3 – 4 divided doses. The maximum single dose – 10 mg daily – 16 mg.

Side Effects

From the of the nervous system. headache, dizziness, irritability, delusions, hallucinations, fatigue, decreased concentration, psychoses.
Effects due to anticholinergic activity . dryness of the mouth, paresis of accommodation, increased intraocular pressure, constipation, urinary retention (including the prostate cancer), tachycardia, decreased sweating.
From the digestive system . nausea, vomiting.
Allergic reactions . skin rash.
Others . purulent parotitis (due to xerostomia), flushing of the skin, decreased muscle tone, possible development of drug dependence.

Overdose

Large doses of trihexyphenidyl cause blockade postganglionic endings of the parasympathetic nervous system, poisoning the picture corresponds to the poisoning of atropine (mydriasis, dryness of the oral mucous membranes, tachycardia, atony bowel and biliary tract. Fever). Disorders of the central nervous system symptoms are expressed in mental and motor excitation may develop coma or paralysis of the respiratory center.
Chelation Therapy . there is no specific antidote. First Aid: gastric lavage, activated charcoal, symptomatic treatment.

Drug Interactions

In a joint application with the H1 – histamine blockers, phenothiazine derivatives, tricyclic antidepressants increase the expression of peripheral anticholinergic effects with chlorpromazine – possible decrease in its plasma concentrations.
Under the influence of reserpine antiparkinsonian effect of reduced trihexyphenidyl (dopamine depletion of the reserves of the central nervous system, activation of cholinergic neurons).
Levodopa increases the activity of anti-trihexyphenidyl. When applied with both drugs levodopa dosage should be reduced. Usually it is sufficient to 3 – trihexyphenidyl 6 mg per day, divided into two steps.
Under the influence of monoamine oxidase inhibitors may increase the anticholinergic action of anticholinergics used in parkinsonism.
In an application trihexyphenidyl reduced effect of sublingual nitrates used (due to dry mouth).
depressive effects of alcohol and drugs that affect the central nervous system may be enhanced when used with trigeksifenidilom.

Cautions

During the period of treatment should refrain from driving motor vehicles and activities potentially hazardous activities that require high concentration and psychomotor speed reactions. Treatment should not be stopped suddenly. If you are taking the drug there is dryness of the mouth, it is desirable to take before eating, as otherwise it may appear nausea.
At the end of treatment or in case of alternative treatment trihexyphenidyl dose should be reduced gradually.
Patients older than 60 years is prescribed with extreme caution – the sensitivity to the drug – the possibility of deterioration of memory and thinking. When large doses of the drug or in patients with predisposing factors (atherosclerosis, advanced age or patients who previously appeared idiosyncrasy on what – or a drug) can appear mental disorders (unnatural increase in mood, agitation, irritability), vomiting or nausea . In these cases it is necessary to stop treatment. During long-term treatment severity of side effects caused by anticholinergic effect, decreases. It is necessary to periodically monitor eye pressure.

Release Form

2 mg tablets. 10 tablets in blisters. 5 contour cell packages with instructions for use in a pile of cardboard.

Storage

The list of number 1 PKKN potent substances. In a dry, protected from light and the reach of children, at a temperature no higher than 25 ° C.

Shelf Life

5 years. Do not use beyond the expiration date printed on the package.

Terms holidays

Manufacturer

The Federal State Unitary Enterprise “Moscow Endocrine Plant”), 109052, Moscow, ul. Novokhokhlovskaya, 25.
Consumer Complaints sent to the address of the manufacturer.