• Pantoprazole general information

      • Pantoprazole *

      • Description of the active substance pantoprazole / Pantoprazole.

      • Pharmacological Properties

      • Indications

      • How to use and dosage of pantoprazole

      • Contraindications

      • Restrictions on the use

      • Pregnancy and breastfeeding

      • Adverse effects of pantoprazole

      • The interaction of pantoprazole with other substances

      • Overdose

      • Trading names of drugs with working substance pantoprazole

Protonix Pantoprazole 20, 40 mg
Most popular brand: Protonix
Active ingredient: Pantoprazole
Available dosage forms: 20, 40 mg
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Pantoprazole general information

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Oxytetracycline is a wide spectrum antibiotic that’s active against a wide selection of bacteria. Tetracyclines are indicated in curing trachoma, even though the infectious agent isn’t always eliminated, as judged by immunofluorescence. Due to this issue, some veterinarians are reluctant to make use of these drugs. Since tetracycline antibiotics aren’t generally permitted in drug-free competition, it is significant to check with all the individual regulatory group. Because humans and animals often don’t fully metabolize pharmaceuticals in their own entire body, they are able to excrete drugs or their breakdown goods, which may the enter the surroundings. Chemical lightsticks are suggested due to their safety, Road flares may be used but aren’t as safe as the lightsticks.

Chronic prostatitis has become the most typical complication. Sebaceous gland linked to the hair follicle. Redness of the skin made by congestion of the capillaries which might result from quite a few causes. It’s to be noted that in the entire lack of sebum, acne will not occur.

Oxytetracycline is a sort of medicine referred to as a tetracycline antibiotic. Used to take care of wound plus together with mild respiratory infections. You have notices your eyelashes become matted with dry yellow skin. Swallow the tablets with a lot of water. The better prepared you’re, the better your chances you’ll survive.

Pantoprazole *

Description of the active substance pantoprazole / Pantoprazole.

formula: C16H15F2N3O4S, chemical name: 5 – (difluoromethoxy) – 2 – [[(3,4 – dimethoxy – 2 – pyridinyl) methyl] sulfinyl] – 1H – benzimidazol (as sodium . salts)
Pharmacological group: Organotropona funds / gastro – intestinal agents / proton pump inhibitors
Mode of action: protivoyazvennoe.


Pharmacological Properties

Pantoprazole accumulate in the tubules of parietal cells of the stomach is converted to the cyclic sulfenamide (the active form of the drug) that selectively interacts with the H + – K + – ATPase (forms a covalent bond and inhibits it). Thus pantoprazole gives transfer into the gastric lumen of hydrogen ions parietal cells and blocks the final phase of hydrochloric acid. Pantoprazole dose-dependently stimulated and continuously suppresses basal production of hydrochloric acid. When in vivo studies the mean effective doses ranging from 0.2 to 2.4 mg / kg. The maximum effect of pantoprazole is possible only in a highly acidic medium (pH = 3). Pantoprazole is virtually inactive at higher pH values. Pantoprazole has antibacterial activity against Helicobacter pylori, and also contributes to the manifestation of H. pylori effects of other drugs.

IPC pantoprazole equal to 128 mg / l. Therapeutic effects in single dose of the drug occur rapidly and last for days. Pantoprazole is rapidly reduced symptoms and promotes healing of duodenal ulcer. When receiving 40 mg pH> 3 last more than 19 hours. After 2 weeks of treatment in 89% of patients showed complete healing of duodenal ulcers. After 4 weeks treatment complete healing of gastric ulcers is observed in 88% of patients. recurrence rate is 55% after treatment of peptic ulcers. Within 4 weeks of therapy in 82% of patients with gastroesophageal reflux 2 – 3 stages provided complete remission after 8 weeks – 92%. After 4 weeks of treatment in 57% of children 6-13 years with gastroesophageal reflux disease 1c / 2 stage achieved complete endoscopic remission. Within 4-8 weeks of therapy in the plasma level increased 1.5 fold gastrin. Maintenance treatment of patients with peptic ulcer disease was accompanied by a slight increase in the number of enterochromaffin-like (ECL) cells.

Experimental carcinogenicity studies show that prolonged use of pantoprazole is associated with an increased possibility of the ECL hyperplasia – cells and the development of carcinomas and adenomas of the liver, gastric carcinoid, neoplastic processes in the thyroid.

Pantoprazole is completely and rapidly absorbed by ingestion. The absolute bioavailability of pantoprazole is 70-80%. Maximum concentration is achieved in 2-4 hours. With pantoprazole plasma protein binds to 98%. half-life is 0,9-1,9 hours clearance – 0.1 l / h / kg, a volume of distribution – 0.15 L / kg. Pantoprazole is excreted in breast milk, the blood-brain barrier penetrating very poorly. Food intake of antacids or at maximum concentration, AUC, and bioavailability is not affected. Proportional increase in the dose increases the maximum concentration and AUC. The values ​​of clearance and half-life is independent of dose. Pantoprazole is metabolized in the liver by oxidation, conjugation, dealkylation. By cytochrome P450 drug it has a low affinity, mainly involved in the metabolism of isozymes CYP2C19 and CYP3A4. The major metabolites of pantoprazole -2 demetilpantoprazol sulfated conjugate (with a half-life of 1.5 hours). Pantoprazole is not accumulates. Metabolites excreted as urine mainly (82%) in the feces is detected in small amounts. In patients with liver cirrhosis the half-life is increased to 7-9 hours, in renal insufficiency – increased slightly, but the half-life period, the main metabolite is 2-3 hours. The maximum concentration and AUC in the older age group is slightly higher.


The exacerbation of peptic ulcer disease (including refractory to the treatment of histamine H2 – receptors or associated with the use of nonsteroidal anti-inflammatory drugs); , Ellison – Syndrome Zollinger gastroesophageal reflux disease (moderate and severe forms); Combined treatment of H. pylori eradication in patients with peptic ulcer to reduce the frequency of relapses.

How to use and dosage of pantoprazole

Pantoprazole ingested (not crush or dissolve, regardless of the meal), administered intravenously (only if oral administration is not possible). Monotherapy with gastroesophageal reflux disease, peptic ulcer disease – usually 40 mg / day, may increase the dose to 80 mg / day. The duration of treatment of duodenal ulcer is 2 weeks, gastroesophageal reflux disease and peptic ulcer stomach- 4 weeks. Eradication of Helicobacter pylori: use only in accordance with the recommended combinations; duration of treatment 7 days (maximum 14 days).

Before treatment pantoprazole is necessary to exclude malignant disease of the stomach and esophagus. Reflux disease should be confirmed endoscopically. Do not use pantoprazole in patients with non-ulcer dyspepsia origin. Elderly patients and for violations of renal function the dose of 40 mg / day are not recommended to exceed. In severe hepatic insufficiency dosage regimen must be adjusted under the supervision of a physician.


Hypersensitivity, liver cirrhosis and hepatitis, which are accompanied by severe hepatic failure.

Restrictions on the use

Violations of the functional state of the liver, the age of 6 years (no experience of use of the drug).

Pregnancy and breastfeeding

When pregnancy is possible the use of pantoprazole only under strict indications, where the benefits to the mother above the possible risk to the fetus. At the time of treatment pantoprazole must stop breastfeeding.

Adverse effects of pantoprazole

digestive system: diarrhea, dry mouth, nausea, increased appetite, belching, flatulence, vomiting, abdominal pain, increased liver transaminases activity, constipation, gastrointestinal carcinoma;
sense organs and the nervous system: headache, asthenia, somnolence, dizziness, insomnia, nervousness, tremor, depression, paresthesia, visual disturbances, photophobia, tinnitus;
urogenital system: swelling, hematuria, impotence;
skin: acne, alopecia, exfoliative dermatitis;
allergic reactions: urticaria, rash, angioedema itching;
other: myalgia, hyperglycemia, fever, hyperlipoproteinemia, eosinophilia, hypercholesterolemia.

The interaction of pantoprazole with other substances

Pantoprazole may reduce the pH – dependent absorption of ketoconazole and other drugs (absorption depends on the level of pH). Pantoprazole is compatible with drugs that are metabolized by the enzyme system involving cytochrome P450: diazepam, phenazepam, digoxin, carbamazepine, theophylline, diclofenac, piroxicam, naproxen, phenytoin, nifedipine, metoprolol, , ethanol. Pantoprazole on the effectiveness of hormonal contraceptives is not affected.


When pantoprazole overdose symptoms are not described. If you suspect an overdose of pantoprazole must be symptomatic and supportive treatment; hemodialysis ineffective.

Trading names of drugs with working substance pantoprazole

Zipantola Kontrolok® Krosatsid


Pantazi Pantap

Panum® Peptazol

Your question – the subject of long-standing debate among doctors
-. Effective and relatively safe drug for the treatment of diseases associated with high intensity of gastric acid production
Pantoprazole -. A proton pump inhibitor that has, compared with omeprazole greater bioavailability, but smaller antisecretory activity and clinical efficacy in the treatment of peptic ulcer, reflux – esophagitis I degree and 8 – week treatment of reflux – esophagitis grade II and III according to Savary-Miller (equivalent daily doses of 20 mg omeprazole and 40 mg of pantoprazole) .
differ and possible side effects.
Of the two proton pump inhibitor pantoprazole can definitely be recommended only when necessary joint application with clopidogrel or citalopram.

love 60 years 2. Mon, 27/04/2015 – 19:52

I have a hemorrhagic erosions of the stomach may be they from taking warfarin? If so, how to drink zovantu. Thank you

Natalia 56y.o. 2. Thu, 28/05/2015 – 08:48

I have a stomach ulcer and erosive gastritis in the beginning I was assigned to a biopsy and then panteprazol . What’s the difference, rabeprazole dear to me. I have an ulcer 1 cm. Thank you

Their action is a little different. And besides, the effectiveness of rabeprazole in treatment of acid-related diseases is higher than that of pantoprazole. But you can stretch to a substitution after consulting a doctor.

Olga Mon, 22/06/2015 – 14:18

I am 59 prednisolone therapy at diagnosis of dermatomyositis To mitigate the side effects of his appointed pantaprazol read the instructions I see that he too is quite strong Can I use omeprazole and three times better question – after the doctor recommended chemotherapy Poliksidony candles to enhance immunity .a my current therapy I realized directed contrary to immunosuppression is this true and if so should I stop using these candles

Thank you in advance for the answer

ALBIN Sat, 16/01/2016 – 15:15