• Imipramine general information

      • IMIPRAMINE (imipramine)

Tofranil Imipramine 25, 75, 50 mg
Most popular brand: Tofranil
Active ingredient: Imipramine
Available dosage forms: 25, 75, 50 mg
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Imipramine general information

Imipramine was the very first TCA. Taper slowly, over a few weeks or longer. First usage of imipramine occasionally causes a rise in anxiety that normally diminishes in many weeks. Use Glucophage as instructed by your doctor. Gabapentin prevents allodynia and hyperalgesia connected with PHN pain, along with the associated sleep disorders. Pharmacists can deploy quite a few tools at their disposal to improve zoster immunization rates.

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Click here to join for our newsletter If you’re a healthcare provider and you would like to further your comprehension of prescription medications, street drugs and get your C.E.U’s in the method, The Road Back recommends The Addictions Academy. You might need to stop utilizing the medicine for a brief time.Do not stop employing imipramine without first speaking to your doctor. If you don’t spend the medication first thing each morning, spend the Neuro Endure Mini first thing. An overdose of imipramine might be fatal. You shouldn’t stop taking imipramine suddenly. The pre-taper is truly that simple.

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IMIPRAMINE (imipramine)

Set individually. Adults ingestion – 25 – 50 mg 3 – 4 times / day; / m – 100 mg / day in divided doses.

Babies when administered at the age of 6 – 12 years – 10 – 30 mg / day in 2 divided doses; over 12 years – 25 – 50 mg / day in divided doses if necessary and taking into account the tolerance dose can be gradually increased. The scheme of treatment set individually.

When bedwetting, depending on their age – 25 – 75 mg 1 time / day for 1 hour before bedtime.

The maximum doses: when administered to adult outpatients – 200 mg / day in the hospital – 300 mg / day; for elderly patients – 100 mg / day; for children – 100 mg / day,.

CNS: tremor, nervousness, restlessness; when used in high doses may be sleep disturbances, intense fear, confusion; rarely – ringing in the ears, seizures, convulsions.

Cardio – vascular system: tachycardia, hypotension, dizziness due to orthostatic hypotension; when used in high doses – arrhythmias.

Allergic reactions: is rare – skin rash, itching, photosensitivity, swelling of the face and tongue, eosinophilia.

From a metabolism: a decrease of protein content in the blood serum.

Liver: , rarely – cholestatic jaundice.

From endocrine system: is rare – breast enlargement, galactorrhea.

From the hematopoietic system: in a few cases – agranulocytosis.

Effects due to anticholinergic action: may be dry mucous membranes, accommodation disturbances, pain in the eyes, constipation, urination disorders.

Contraindications

Violations function blood-forming organs, the liver and / or kidney disease, heart failure, acute phase of myocardial infarction, angle-closure glaucoma, atony bladder, benign prostatic hyperplasia, I trimester of pregnancy, lactation, hypersensitivity to imipramine and other tricyclic antidepressants, derivatives dibenzoazepina.

Pregnancy and breastfeeding

is contraindicated in the I trimester of pregnancy, during lactation.

Do not apply in the II and III trimester of pregnancy, except in cases of extreme necessity. There are no adequate and well-controlled studies safety of imipramine in human pregnancy has not been conducted, but there is clinical evidence of congenital malformations associated with the use of imipramine.

Application for violations of liver function

is contraindicated with abnormal liver function.

Application for violations of renal function

is contraindicated in violation of renal function.

Use in children

For the treatment of bedwetting in children shows imipramine hydrochloride (but not pamoate). Not recommended for oral administration to children under 6 years old, in / m – children up to 12 years.

To use caution in patients with a low seizure threshold; with severe liver or kidney disease; during treatment with steroids; in pheochromocytoma and neuroblastoma of the – of the risk of a hypertensive crisis; in hyperthyroidism; diabetes (required dosing regimen hypoglycemic drugs correction).

It should not be used in conjunction with sympathomimetic drugs, including epinephrine, ephedrine, isoprenaline, norepinephrine, phenylephrine, phenylpropanolamine. Imipramine can be applied not earlier than 14 days after discontinuation of MAO inhibitor therapy starting with the lowest dose. With simultaneous use of imipramine with alprazolam or disulfiram require a dose reduction of imipramine.

Tricyclic antidepressants should not be used in combination with hinidinopodobnyh antiarrhythmic drugs.

Before treatment is necessary to monitor blood pressure, in the period of treatment to monitor patterns of peripheral blood during prolonged therapy – control functions of the cardio – vascular system and the liver.

Patients with a tendency to suicide in the initial phase of treatment requires constant medical supervision. The use of electric shock during treatment with imipramine requires special care.

During the period of treatment should be deleted alcohol use.

For the treatment of bedwetting in children shows imipramine hydrochloride (but not pamoate). Not recommended for oral administration to children under 6 years old, in / m – children up to 12 years.

Effects on ability to drive vehicles and management mechanisms

During the period of treatment should refrain from potentially hazardous activities requiring increased attention and rapid psychomotor reactions.

In an application with drugs, have a depressing effect on the CNS, with ethanol may be a significant increase in inhibitory action on the central nervous system, on the respiratory function, increased hypotensive effect.

At simultaneous application with MAO inhibitors significantly increases the risk of excitation, seizures, blood pressure fluctuations, hyperthermia, coma.

In an application with anticholinergics observed additive anticholinergic effects.

In an application with drugs thyroid hormones are enhanced adrenergic effects caused by increased sensitivity adrenergic receptors under the influence of thyroid drugs and inhibition of inactivation (transport adrenergic axons) norepinephrine influenced imipramine, which can cause tachyarrhythmias and development of angina attacks.

While the use of agonists (epinephrine, norepinephrine, phenylephrine) increases the risk of tachycardia, arrhythmia and hypertension due to inhibition of inactivation of catecholamines imipramine.

In an application with barbiturates may reduce imipramine plasma concentrations.

In an application with antihypertensive effect of Clonidine decreases, which may be due to the inhibition of its binding to the presynaptic & alpha; – Adrenoceptor.

While the use of , , imipramine increased plasma concentrations due to the inhibition of CYP2D6 isoenzyme under the influence of paroxetine, or sertraline.

In an application with ritonavir is likely to increase imipramine plasma concentrations; – may increase the concentration of phenytoin in blood plasma; with quinidine – imipramine may increase the plasma concentration due to a decrease in its excretion. On – This is probably due to the inhibition of metabolism of imipramine under the influence of quinidine.

In an application with imipramine cimetidine slows the metabolism, increases its concentration in blood plasma and develop toxic effects.

While the use of estrogen may be in breach of imipramine metabolism.

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