Buy Generic Diovan (Valsartan) 40, 80, 160 mg online

Last Updated on February 19, 2017 by Dr.Derek Fhisher

Most popular brand: Diovan
Active ingredient: Valsartan
Available dosage forms: 40, 80, 160 mg

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Valsartan general information

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Although it helps in the therapy for heart-related conditions like angina, an overdose can change the cardiovascular system. Consequently, various a1 blockers are utilized in healing hypertension to balance the higher blood pressure. These were a number of the feasible causes linked to this condition. In such circumstances, the individual has to really go for sure tests, such as the electrocardiogram, which are useful in diagnosis of the condition.

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valsartan (Valsartan): instruction, and the use of a formula

Therapeutic agents Valsartan

angiotensin receptor antagonists II (AT ₁ – subtype)

The nosological classification (ICD – 10)

Code CAS

Feature substance Valsartan

A white or almost white powder. Soluble in ethanol and methanol, slightly soluble in water. The molecular weight of 435,5.

Pharmacology

Mode of action -. Antihypertensive

Competitive blocking the receptors of angiotensin II (AT subtype ₁ ), located in the blood vessels, heart, kidneys, brain, lungs, and adrenal cortex. Suppresses all mediated through the AT ₁ receptor effects of angiotensin II, including vasoconstriction and aldosterone secretion. It reduces myocardial hypertrophy in hypertensive patients. No effect on total cholesterol, triglycerides, glucose and uric acid.

The antihypertensive effect develops within 2 hours after a single dose, reaching a maximum of 4 –. 6 hours and lasts up to 24 hours When used regularly, sustained reduction in blood pressure occurs within 2 – 4 weeks.

Rapidly absorbed from the gastrointestinal tract. Bioavailability is 10 – 35% (average 25%). C _max is achieved through a 2 –. 4 hours Eating reduces AUC by 40% and C _max 50% without altering the efficiency. Plasma protein binding (mostly to albumin) 94 – 97%. The volume of distribution ; 17 l. A small proportion (20%) biotransformed to inactive metabolites (Valeria 4 – hydroxy valsartan) and the main ; excreted unchanged mainly in faeces (70%) and urine (30%). T _1/2 about 9 hours.

AUC and C _max increase in elderly patients (over 65 years) to 70% and 35%, respectively.

In experimental studies in mice and rats had no carcinogenic activity at 24 – monthly administration at doses up to 160 (mouse) and up to 200 mg / kg / day (rat), which corresponds to 2.6 and 6 MRDC. The male and female rats (200 mg / kg / day orally) adverse effects on reproductive function not provided. The mutagenic properties of valsartan were found.

Application of the substance Valsartan

Hypertension; Chronic heart nedostatochnoct (II – IV functional class NYHA classification) in the complex therapy; increase survival of patients with acute myocardial infarction complicated by left ventricular failure and / or left ventricular systolic dysfunction, the presence of a stable hemodynamic parameters.

Contraindications

Hypersensitivity, pregnancy, breast-feeding.

Restrictions on the use

Age 18 years (effectiveness and safety have not been proven).

Application of pregnancy and breastfeeding

is contraindicated in pregnancy.

Category effects on the fetus by FDA ; D.

At the time of treatment should stop breastfeeding (not known whether valsartan is excreted into breast milk).

Side effects of substance Valsartan

From the nervous system and sensory organs: rare ; weakness, headache, dizziness.

From the digestive tract: rare ; diarrhea, nausea, abdominal pain, increased liver transaminases.

From the cardio – vascular system and blood (blood, hemostasis): rare ; neutropenia (1.9%), anemia, decrease in hematocrit.

Other: rare ; cough, hyperkalemia, viral infection.

Interaction

(mutually) the hypotensive effect of diuretics. Potassium-sparing diuretics, and drugs containing potassium, increase the risk of hyperkalemia.

With simultaneous use of lithium-containing medicines with angiotensin II receptor antagonists, including valsartan, noted reversible elevation of lithium in blood serum and increased its toxic effects. In this regard, lithium is recommended to control serum.

Dual RAAS blockade

Dual blockade of the renin – angiotensin – aldosterone system (RAAS), angiotensin receptor antagonists, ACE inhibitors or aliskiren is associated with an increased risk of hypotension, hyperkalemia, and renal dysfunction (including acute renal failure) compared with monotherapy these drugs. It is necessary to carefully monitor blood pressure. renal function and electrolyte balance in patients taking valsartan and other drugs. influencing the RAAS.

NSAIDs. including selective inhibitors of COX – 2

In elderly patients with reduced BCC (including with diuretic therapy), or impaired renal function, combined use of NSAIDs. including COX – 2 with angiotensin II receptor antagonists, including valsartan, may lead to a deterioration of renal function, including possible acute renal failure. These effects are usually reversible. Patients receiving valsartan and NSAIDs. necessary to monitor kidney function.
When applied simultaneously with NSAIDs antihypertensive effect of angiotensin II receptor antagonists, including Valsartan may be weakened.

The study in vitro on the culture of human liver valsartan is a substrate for protein – transporter OATR1V1 and MRP2. The combined use of valsartan with protein inhibitors – OATR1V1 transporter (rifampicin, tacrolimus) or MRP2 (ritonavir) may increase the systemic exposure of valsartan.

Overdose

Symptoms: hypotension, tachycardia or bradycardia.

Treatment: symptomatic therapy; Dialysis is ineffective.

Dosing and Administration

Inside, the recommended dose in patients with arterial hypertension of 80 mg 1 time per day; the lack of effectiveness may increase the dose to 160 mg or additional appointment of another antihypertensive drug (eg a diuretic). The maximum daily dose of 320 mg.

Precautions agent Valsartan

Caution should be exercised in the appointment of patients with deficiency of sodium and / or a pronounced decrease in the bcc (from – to an increased risk of excessive hypotension), with bilateral renal artery stenosis or stenosis of the renal artery to a solitary kidney (necessary to monitor the concentration of creatinine and urea nitrogen serum), with severe renal impairment (creatinine clearance less than 10 ml / min), severe hepatic impairment, biliary cirrhosis, biliary tract obstruction, the concomitant use of potassium-sparing diuretics, potassium-containing medications or potassium supplements.

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Trading names of drugs with working substance