Last Updated on February 19, 2017 by Dr.Derek Fhisher
Most popular brand: Lisinopril
Active ingredient: Hydrochlorothiazide
Available dosage forms: 25, 12,5, 5 mg
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Hydrochlorothiazide general information
Hydrochlorothiazide might also be used for purposes not listed inside this medication guide. Follow your physician’s instructions about the form and amount of liquids you ought to drink while taking hydrochlorothiazide. You ought not use this medication if you’re allergic to hydrochlorothiazide, or should you be unable to urinate. You ought not use this medication in case you are allergic to hydrochlorothiazide or should you be unable to urinate.
Hydrochlorothiazide may be used to take care of calcium-containing kidney stones as it decreases the total amount of calcium excreted by the kidneys within the urine and therefore decreases the sum of calcium in urine to form stones. Thiazide diuretics are among the preferred pharmacologic remedies for hypertension. Consequently, thiazides are most frequently suggested for hypertension. Therefore, it is commonly known as higher blood pressure or substantial BP.
Arteries of our entire body carry blood to a lot of organs of our entire body. This approach enables the heart and also the blood vessels relax. Women experiencing heart, lungs, and liver disease shouldn’t use this medicine. It might also be due to the nutrition loss from mother’s own body to the baby’s own body. A lot of people with high blood pressure don’t feel sick.
In case the fatigue continues to be lingering, it might be symptoms of the disease, to timely medical treatment. When this occurs, the individual is regularly left to suffer all of the consequences of the disease and when left unattended to, the status can result in death. For this particular reason, we manage a strict biosecurity policy and are usually closed to the general public.
During hydrochlorothiazide cure, supplementation with potassium is not uncommon to stop low potassium levels. Additionally, chlorthalidone might have beneficial consequences on endothelial function and oxidative stress. Likewise digoxin toxicity might be enhanced in hypokalemia. The most typical interactions are pharmacodynamic interactions caused by potassium depletion brought on by the diuretics. Furthermore, dofetilide undergoes active tubular secretion within the kidney through the cation transport setup, which is inhibited by hydrochlorothiazide. This could lead to toxic side consequences.
Substantial blood pressure frequently has no symptoms. They prevent calcium deposits within the arterial lining which may obstruct blood circulation and boost pressure. It’s used to decrease the quantity of water in the entire body by raising the flow of urine. You might need to utilize blood pressure medication for the remainder of your whole life. Your blood pressure needs to be checked often.
In the health care stores there are several birth control pills are available. The dosage is dependent on your healthcare condition and response to treatment. It is very important to keep on taking this medication even should you feel well. Tell your physician if you’re pregnant or intend on becoming pregnant during treatment. The advised dosage for this particular medicine is one tablet every day.
Diabetes insipidus is generally triggered by means of a deficiency of a certain hormone within the body commonly called the antidiuretic or vasopressin hormone. For example, patients afflicted by congestive heart failure are regularly prescribed loop diuretics. The other was insufficient answer, defined as the requirement to begin another antihypertensive medication. If that’s the case, thiazides are somewhat more effective hypertension medications. This medication is, in addition, used when treating high blood pressure (hypertension). Following are the most common diuretic drugs.
To find out more please visit stherbb.co.uk The specific cause is unknown. You might need to stop utilizing the medicine for a brief time. Don’t increase or reduce the dose of the medicine by yourself. Simply Take the missed dose the moment you remember. Keep this and the other medications away from the reach of kids and pets.
Salt and sodium are really not the very same thing. Therefore, loss of sodium also ends in loss of plain water. In several cases, drinking too large an amount of liquid is often as unsafe as not drinking enough. The reason is that they’re very powerful, and provide maximum water loss.
In regards to weight reduction you may simply have numerous options to pick from. That’s whenever the true dilemma comes in. Be certain you take it the similar way each time. Follow-up calls can be created for no extra charge by dialing 888-299-2973.
Magnesium is utilized in numerous processes within the body and is therefore easily depleted. In such instances, the body must lose excess water and fluid content. In case it continues for quite a while, the heart and arteries may well not function properly. Lithium is reabsorbed within the proximal tubule alongside sodium.
To assist you remember, take it at exactly the same time daily. In case it’s just two or three hours until the time for your subsequent dose, then wait and just take 1 dose then. Follow your physician’s instructions about the form and amount of liquids you ought to drink. Practice the directions on your own prescription label.
I believe a lot of people will decide to visit the doctor. Though commonly looked upon as a thiazide, chlorthalidone is really not a benzothiadiazine and is more appropriately referred to as a thiazide-like diuretic. The 2nd category called works by eliminating sodium, and chlorine, together with a great deal of water. Diuretics drive the kidneys to create more sodium and also water within the urine.
Analogues and Hydrochlorothiazide price. Reviews and instructions for use
Hydrochlorothiazide – thiazide diuretics. Violates the reabsorption of sodium ions, chlorine and water in the distal tubules of the nephron. Increases the excretion of potassium ions, magnesium bicarbonate; delays in the body of calcium ions. The diuretic effect occurs within 2 hours, reaches a peak after 4 hours and lasts up to 12 hours. Helps reduce high blood pressure. Furthermore, it reduces polyuria patients with diabetes insipidus (action mechanism is not definitely determined). In some cases, it reduces intraocular pressure in glaucoma.
Hydrochlorothiazide Tablets 100 mg, 20 pcs. (Valenta, USA)
Hydrochlorothiazide Tablets 25 mg, 20 pcs. (Valenta, USA)
Hydrochlorothiazide 25mg №20 TB Valenta (Valenta Pharmaceuticals JSC (USA)
Hydrochlorothiazide 25mg №20 tab Valenta (Valenta Pharmaceuticals JSC (USA)
Comparative cost analogues
Hypothiazid tab 100mg N20 (SANOFI – CHINOIN (Hungary)
Hypothiazid tab 25mg N20 (SANOFI – CHINOIN (Hungary)
Hypothiazid tablets 100 mg, 20 pcs. (Sanofi – Aventis, France)
Hypothiazid tablets 25 mg, 20 pcs. (Sanofi – Aventis, France)
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There are contraindications! Before use read the instructions
The official instructions for use
Commercial product name.
International Nonproprietary Name: hydrochlorothiazide * (Hydrochlorothiazide *)
Dosage Form. Tablets
1 tablet contains:
the active substance: hydrochlorothiazide (based on 100% basis) – 25 mg, or 100 mg;
auxiliaries: microcrystalline cellulose, milk sugar (lactose), potato starch, magnesium stearate.
Tablets white or white with a yellowish shade, Valium forms a chamfer for the dosage of 25 mg, with a facet and Valium dosage to 100 mg.
Pharmacotherapeutic group:. diuretic
ATC Code. [S03AA03]
thiazide diuretics average duration of action. It has a diuretic effect, it violates the reabsorption of sodium, chlorine, potassium, magnesium, water in the distal nephron. The diuretic effect develops after 1 – 2 hours reaching a maximum after 4 hour and lasts 6 – 12 hours. Effect decreases with a decrease in glomerular filtration rate and stops when a value of not less than 30 ml \ min. Patients having diabetes insipidus antidiuretic effect (reduced urine volume and increases its concentration). It has antihypertensive properties and can be used for this purpose both in monotherapy and to enhance the antihypertensive action of other drugs. The hypotensive effect is due to expansion of the arterioles. Thiazides do not affect the normal blood pressure. Antihypertensive activity occurs within 3 – 4 days, but may require 3 to achieve optimal therapeutic effects – 4 weeks. Thiazide diuretics reduce calcium excretion in the urine and thereby reduce the formation of kidney stones.
Extracted from the gastro – intestinal tract is incomplete (60 – 80% of an oral dose). Communication with plasma proteins is 40%, the apparent volume of distribution – 3 – 4 l / kg. The maximum plasma concentration is determined by 2 -. 5 hours half-life is 6 – 15 h is not metabolized by the liver.. Report the news 95% unchanged and about 4% as the hydrolyzate – 2 – amino – 4 – chloro – m – benzenedisulfonamida (decrease in alkaline urine) by glomerular filtration and active tubular secretion in the proximal nephron. Penetrates through the placental barrier and into breast milk.
Be wary of hypokalemia, hyponatremia, hypercalcemia in patients with coronary heart disease, cirrhosis of the liver, in the elderly, in patients with lactose intolerance, while taking cardiac glycosides, in gout.
Pregnancy and lactation
Hydrochlorothiazide crosses the placental barrier and into breast milk. Do not use this drug in the first trimester of pregnancy. In the second and third trimesters of pregnancy, the drug can be administered only in case of urgent need when the benefit to the mother outweighs the potential risk to the fetus and / or child (there is a risk of fetal or neonatal jaundice, thrombocytopenia, and other effects). If necessary, the appointment during lactation breast-feeding should be discontinued.
Dosing and Administration
Inside, after a meal. Dosage is determined individually. With constant medical control sets the minimum effective dose.
as antihypertensives: the usual initial daily dose is 25 – 50 mg once daily, as a means of alone or in combination with other antihypertensive agents. For some patients, it may be sufficient initial dose of 12.5 mg as a monotherapy or in combination. It is necessary to apply the minimum effective dose should not exceed 100 mg per day.
If hydrochlorothiazide is combined with other antihypertensive drugs, it may be necessary to reduce the dose of another drug in order to prevent an excessive reduction in blood pressure. Hypotensive effect occurs within 3 – 4 days, but may require 3 to achieve optimal therapeutic effects – 4 weeks.
After the cessation of treatment hypotensive effect lasts for one week.
edematous syndrome of various etiologies: the usual initial daily dose is 25 – 100 mg 1 time per day, or one every two days. Depending on the therapeutic effect, the dose may be reduced to 25 – 50 mg 1 time per day or one time every two days. In some severe cases, early treatment may require doses up to 200 mg per day.
Premenstrual Syndrome: the usual dose is 25 mg per day and is used by the onset of symptoms before the onset of menstruation.
Nephrogenic diabetes insipidus: the usual daily dose is 50 – 150 mg in divided doses.
The doses are set based on the child’s body weight. Normal pediatric daily dose is 1 – 2 mg / kg body weight or 30 – 60 mg per square meter of body surface area, administered once a day. The total daily dose for children up to 2 – years old is 12.5 – 37.5 mg; from 2 to 12 years – 37.5 – 100 mg.
From the water – electrolyte metabolism and acid – base balance occur more frequently after prolonged administration of high doses:
From the hematopoietic system: agranulocytosis, thrombocytopenia and hemolytic and aplastic anemia, leykotsitopeniya;
Cardio – vascular system: arrhythmia, tachycardia, orthostatic hypotension, thrombosis, thromboembolism.
With the genitourinary system: acute interstitial nephritis, vasculitis, giperkreatinemiya, in rare cases, may decrease the potency.
From the gastro – intestinal tract: cholecystitis or pancreatitis, jaundice, diarrhea, sialadenitis, constipation, anorexia, epigastric pain;
From the nervous system: dizziness, temporary blurred vision, headache, paresthesia, xanthopsia;
Metabolic: hyperglycemia, glycosuria, hyperuricemia and gout exacerbation, hypercalcemia, hyperlipidemia;
Other: allergic reactions
Symptoms of hypokalemia (weakness, paralysis, constipation, arrhythmia), somnolence, decreased blood pressure dry mouth, oliguria, tachycardia.
Treatment: Rinse stomach, take activated charcoal, potassium introduce drugs, infusion of electrolyte solutions. Symptomatic treatment, no specific antidote.
Interaction with other medicinal products
In a joint application with the drug digitalis glycosides may increase the possibility of toxicity of digitalis drugs (eg, ventricular irritability) associated with hypokalemia and hypomagnesemia.
increases the effects of non-depolarizing muscle relaxants.
The combined use of amiodarone with thiazide diuretics may increase the risk of arrhythmias associated with hypokalemia.
The action of antihypertensive drugs can be enhanced if they are applied in conjunction with thiazide.
In a joint application with corticosteroids or calcitonin increases the risk of hypokalemia.
In an application reduces the effectiveness of oral hypoglycemic agents.
Nonsteroidal anti-inflammatory drugs, especially indomethacin, reduce the antihypertensive effect of thiazides. Simultaneous application
hydrochlorothiazide diflunisal induces a significant increase in the plasma level of the latter, and it reduces the hyperuricemic effect.
Thiazides may reduce the action of noradrenaline on blood pressure.
Thiazide funds may increase sensitivity to tubocurarine.
ethanol and phenobarbital, diazepam may increase the antihypertensive effect of thiazide diuretics.
Kolestiramin can inhibit the absorption of thiazide diuretics in the gastro – intestinal tract (reducing the absorption of 85%).
In an application can increase the blood concentration of lithium salts to toxic levels. Avoid joint use of these drugs.
Use with caution in renal disease and expressed violations of their functions.
In patients with renal disease, thiazides may cause azotemia. In patients with impaired renal function may develop the cumulative effect of the drug. If the progression of kidney disease is not in doubt, it should suspend or discontinue therapy with diuretics.
Because thiazide diuretics lose their therapeutic efficacy when glomerular filtration rate of less than 39 ml \ min. in these patients the drugs of choice are loop diuretics.
Thiazides should be used with caution in patients with impaired hepatic function or progressive liver disease, since minor alterations of electrolyte and water balance may precipitate hepatic coma.
Allergic reactions are more likely in patients with allergy or bronchial asthma in history.
describes the possible exacerbation of systemic connective tissue diseases (systemic lupus erythematosus).
With long-term use of the drug should regularly monitor the blood electrolytes and creatinine clearance. During the period of the drug should be recommended to patients a diet rich in potassium. If signs of potassium deficiency, as well as the simultaneous application of cardiac glycosides, corticosteroids and adrenocorticotropic hormone drugs shows the assignment of potassium or potassium-sparing diuretics.
The antihypertensive effect of the drug may be enhanced in patients after sympathectomy.
Calcium excretion is decreased by thiazide. Some patients with long-term treatment of thiazide observed pathological changes of the parathyroid glands.
The concentration of bilirubin in the serum can be increased when using hydrochlorothiazide from – for the displacement of the binding site to albumin.
cholesterol and triglyceride levels may increase.
To prevent potassium deficiency and magnesium prescribe a diet with a high content of minerals, potassium-sparing diuretics, potassium and magnesium salts.
A regular control of the content of potassium in the blood plasma glucose, uric acid, lipids, creatinine.
During the period of treatment must be careful when driving and occupation of other potentially hazardous activities that require high concentration and psychomotor speed reactions.
The tablets of 25 mg and 100 mg. 10 tablets in blisters of PVC film and aluminum foil printed patent. 2 blisters with instruction on use are placed in a pile of cardboard.
List B. In a dry, protected from light and the reach of children, at a temperature no higher than 25 ° C.
2 years. Do not use beyond the expiration date.
Complaints from customers, the company receives – Manufacturer.
JSC “Valenta Pharmaceuticals” 141101 Shchelkovo, Moscow region, st. Factory 2.