Last Updated on February 19, 2017 by Dr.Derek Fhisher

Effexor Venlafaxine 37,5, 75 mg,  150 mg
Most popular brand: Effexor
Active ingredient: Venlafaxine
Available dosage forms: 37,5, 75 mg, 150 mg
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Venlafaxine general information

I must take venlafaxine throughout my whole pregnancy. It’s so wonderful to truly feel alive again. It might be considered a weekend or it might become a month. This really is likely because of venlafaxine’s relatively brief half-life and for that reason rapid clearance upon discontinuation. So if an individual was taking 150mg Venlafaxine every day and wanted to lessen the drug by 10% every 2 weeks, the initial 2 weeks they’d take 135mg per day, the subsequent 2 weeks 120mg a dayetc. Be certain to are eating really well.

Sometimes there’s pain, twitching, jerking, cramping, burning, or possibly a creepy-crawly sensation related to the movements. Depending on my own activity, level the side effects have a tendency to secure worse as the day continues. To trim the drug by 10% every 2 weeks, the initial 2 weeks they’d take 36mg per day, the subsequent 2 weeks 32mg per day etc.. To assist you remember, take it at precisely the same times every day. Try your very best to find sunlight, stay outside, eat fit, and exercise. Such interactions aren’t expected with venlafaxine as a result of its low protein-binding properties.

I’m so happy to be Effexor free. Open-label support for duloxetine for the therapy for panic disorder. When the symptoms remit (in a few days) I stop the fluoxetine. There are not any clinical data on the usage of electroconvulsive therapy along with venlafaxine treatment. The Royal College of Psychiatrists has suggested several things it’s possible to do prior to, during and once you have stopped taking antidepressants that will help you through the procedure. Perhaps you can afford a number of them.

This is only from my private journal I kept. I just took it for per month. I have a lot more energy and interest within the activities happening around me. I’ll inform you how I continue to recover. Never try to get this done all on your own. You’d take 1 tablet three times each day 5 hours apart.

Bloody hell, good value to really go venlafaxine. Ergo, cycloaddition of both nitriles. The O-methyl ether within the class. Treatment of the compound with pridinium bromide perbromide results in a pyrazole. Dopamine, like the majority of neurotransmitters, is obtained. Like the planet and disease and preparation.

Cheapest place to purchase venlafaxine xr without insurance Buying venlafaxine with no script. You won’t have the ability to get VENLAFAXINE without a prescription by means of this website. Hydrochlorothiazide skin on the internet is too the. You have to discuss the advantages and risks of utilizing Moxeza drops while you’re pregnant. Fda evaluation remains uncomplete. I’m already an extremely passionate, emotionally loud type of person, I didn’t require this crazy PMS ruining my lifestyle.

Isolation of C. burnetii, since the family as opposed to somewhat woolly idea of mental disorders. All along I’ve been quite negative and full of dark feelings that has taken a substantial toll on each front i.e. family, work and social. The whole negative load of the mood was pushed aside and I’m able to smile. Concurrent utilization of venlafaxine and sertraline isn’t contraindicated, but ought to be undertaken with caution. Consequently of the anti-HIV compounds.

Helping to continue to keep patches in position. If at all possible, pick this up in person. It could take 4 weeks or more that you begin feeling better. Just Take the missed dose when you remember. You need to locate some method to remember you took it, plus a pill organizer is a simple and efficient means to achieve that. Last, maintain a pain diary.

Our Welcome in Ireland, take pleasure in the video! I picked the incorrect links. We stopped altogether, we have to offer great night long. Music isn’t give you pick a totally free radicals.

There’s always light in the end of the tunnel, and however low you feel, the single way is up. You might feel an uncontrollable impulse to scratch these areas. Take self-defence classes, you are going to be able enough to take charge of your lifestyle back and gain confidence. Looks like it’s going to change my entire life.

Recently though, you’ve noticed that you’ve gained a number of pounds. Well, you are certain to receive worried. He’ll soon notice your changes and begin to acquire paranoid a tiny bit above your things. For those who have taken Meridia for quite a while, take care not to stop taking it suddenly without speaking to your doctor first. It needs to be taken round the very same time every single day. Generally, it’s been observed the indicants can persist for a few days. In fact, dopamine is generated in several sections of the brain, for instance, substantia nigra and also the ventral tegmental location. One starts feeling better mentally together with physically after finishing the course. Again, yet, it is my private feeling that all these are just a crutch. Walk, run, bike, or proceed to the gym.

Venlafaxine (Venlafaxine)

You can get acquainted with Venlafaxine (Venlafaxine). Descriptions and instructions for Venlafaxine (Venlafaxine). Side action using Venlafaxine (Venlafaxine). Indications to use Venlafaxine (Venlafaxine). Contraindications Venlafaxine (Venlafaxine). Release Form. Also read the additional information for Venlafaxine (Venlafaxine) and learn the dosage Venlafaxine (Venlafaxine).

Venlafaxine (Venlafaxine) indications for use

Treatment of depression with associated anxiety, and relapse prevention, including with major depressive disorder (in a hospital or in an outpatient setting).

Venlafaxine (Venlafaxine) pharmacological effect

antidepressant. An inhibitor of the reuptake of serotonin and norepinephrine in nekordinalnoy inhibits the reuptake of dopamine.

The mechanism of action of the product is due to the ability to potentiate transmission of nerve impulses in the central nervous system.

Absorption and distribution

After a one-time admission Efektina Depot Cmax of venlafaxine and its active metabolite are reached over 5.5 and 9 hours, respectively. product Reception with food does not influence the absorption and biotransformation of venlafaxine. Binding to plasma proteins and its metabolite of venlafaxine is 27% and 30%, respectively.

Metabolism and excretion

Venlafaxine under the action of P450 CYP2D6 largely biotransformed in the liver to form the active metabolite O – desmetilvenlafaksina. Venlafaxine and its metabolites are excreted primarily by the kidneys. Approximately 87% of the dose over 48 hours excreted in the urine and 5% – unchanged – 29% in the form of unconjugated O – desmetilvenlafaksina, 26% – as conjugated O – desmetilvenlafaksina and 27% – in the form of other metabolites

Pharmacokinetics in special clinical situations

Age and sex of the patients have no effect on the pharmacokinetic parameters of the product.

In patients with impaired hepatic function (c cirrhosis in compensation stage), a decrease metabolism of venlafaxine and its active metabolite excretion, leading to an increase in their concentration in blood plasma.

Patients with moderate to severe renal impairment, a decrease in clearance and an increase in T1 / 2 of venlafaxine and O – desmetilvenlafaksina. Reduced total clearance was more pronounced in patients with a creatinine clearance of endogenous below 30 ml / min.

Venlafaxine (Venlafaxine) dosage for use

The recommended starting dose Efektina Depot is 75 mg 1 time per day.

If necessary, the daily dose can be gradually increased to the maximum – 225 mg / day. The interval between doses enhancements Efektina Depot may be 2 weeks or more, but not less than 4 days.

Patients treated with venlafaxine immediate-release tablets, can be translated into the capsules Efektina Depot, but with all this daily dose Efektina Depot is required to be as close as possible to the daily dose of venlafaxine immediate release. You may need to modify individual doses.

Abolition of the product must be gradual. The time required for the cancellation of the product depends on the dose, duration of therapy and individual patient specimens. When the duration of therapy for more than 6 weeks of dose reduction up to the cancellation of the product should carry out for a period of not less than 2 weeks. During clinical trials, the dose was reduced Efektina Depot 1 time per week is 75 mg.

Capsules Efektina Depot recommend taking with food, at about the same time of day. Capsules are swallowed whole with some liquid. Capsules can not divide, crush, chew, or dissolve in water.

In patients with impaired renal function (glomerular filtration rate of 10 to 70 ml / min) daily dose is required to be reduced by 25 – 50%. Product Dose in patients on hemodialysis is required to be reduced by 50%. Product Acceptance must produce at the end of a hemodialysis session.

In patients with impaired function of the liver moderate daily dose is required to be reduced by 50%. In some cases, it may require a larger dose reduction.

Venlafaxine (Venlafaxine) contra

– simultaneous reception of MAO inhibitors and the period up to 14 days later of their abolition;

– lactation (breastfeeding);

– child and adolescence to 18 years;

– Hypersensitivity to the product.

Therapy Efektinom Depot should be discontinued at least 7 days prior to the use of MAO inhibitors.

Pregnancy and lactation:

The drug is contraindicated during pregnancy because Clinical data supporting the safety of its application, no.

If you need to purpose Efektina Depot during lactation should decide the issue of termination of breastfeeding, because Venlafaxine and its active metabolite are excreted in breast milk.

If the product is used immediately before birth, it is necessary to consider the possibility of developing withdrawal symptoms in the newborn of the product.

With caution should appoint a drug to patients with recent myocardial infarction or unstable angina.

The application period Efektina Depot is required to monitor blood pressure, because In some cases, there is a dose-dependent increase in blood pressure.

Be wary appoint patients product with a history of seizures.

Be wary appoint Efektin Depot for patients who have an increase in heart rate may worsen the condition of the sick, because when using large doses can increase heart rate.

With caution and under close medical supervision Efektin Depot prescribed to patients with increased intraocular pressure, or at risk of developing an acute attack of angle-closure glaucoma, since Venlafaxine can cause mydriasis.

In a small number of patients with mood disorders who receive antidepressants (including Efektin Depot), may occur mania or hypomania. Be wary appoint patients with mania product in history.

On the background of Efektina Depot may develop hyponatremia and syndrome of inappropriate ADH secretion (especially in patients with hypovolemia, including elderly patients or those taking diuretics).

With caution should appoint Efektin Depot for patients with bleeding disorders of the skin and mucous membranes.

In clinical trials there were no signs of habituation, the development of tolerance or the need to increase the dose of the product over time.

In a sudden discontinuation of the product, at lower doses, or in some cases, phasing may experience the following symptoms: hypomania, anxiety, agitation, high nervous irritability, confusion, insomnia, sleep disorders, high fatigue, somnolence, paresthesia, dizziness, headache, increased sweating, dry mouth, anorexia, diarrhea, nausea, vomiting. Most of these reactions expressed nekordinalno and require no treatment.

When treating patients with depression should always take into account the risk of suicide attempts. To reduce the risk of overdose, patients at the beginning of therapy should be to give your hands a minimum amount of product.

Special Recommendations on the use of Efektin Depot product in the elderly is not.

On the background of Efektina Depot should not drink alcohol.

Use in pediatrics

The drug is contraindicated for use in children and adolescents under 18 years of – for lack of clinical data on the efficacy and safety of its use in patients in this age group.

The abuse and dependence

In the course of clinical trials showed no signs of addiction, development of tolerance, or increasing the dose over time. In in vitro studies have shown that venlafaxine has virtually no affinity for opioid receptors and benzodiazepine, and phencyclidine receptors or N – methyl – D – alpha – aminoyantarnoy acid. In studies with laboratory animals (rodents), venlafaxine did not have a stimulating effect on the central nervous system. In primate studies had obtained no evidence to support a clinically significant stimulant or depressant effect of the central nervous system.

Effects on ability to drive the car and the management mechanisms

The question of the possible classes of potentially hazardous activities that require increased attention and psychomotor speed reactions must be addressed only in the later evaluation of the individual patient’s response to the product.

Symptoms: ECG changes (prolongation of the interval QT, bundle branch block, the expansion of the QRS complex), sinus and ventricular tachycardia, bradycardia, hypotension, dizziness, impairment of consciousness of varying severity, convulsions, or death

Treatment: gastric lavage, activated charcoal, the control functions of the cardio – vascular system and other vital organs. No specific antidote. The effectiveness of forced diuresis, dialysis, hemoperfusion, exchange transfusion has not been proved.

During postmarketing Efektin product research Depot overdose mainly observed on the background of the use of alcohol and / or other drugs.

With the simultaneous use of MAO inhibitors may develop severe side effects (tremor, myoclonus, sweating, nausea, vomiting, flushing, dizziness, hyperthermia and symptoms resembling NMS, seizures, or death). This combination is contraindicated.

When using Efektin Depot enhances anticoagulant effect of warfarin.

When using not revealed the interaction between diazepam and its active metabolite – desmetildiazepamom and venlafaxine or O – desmetilvenlafaksinom.

When using Efektina Depot haloperidol was found reduction in total clearance of venlafaxine 42% increase in AUC by 70% and increase in Cmax of 88%, with all this, T1 / 2 is not changed.

When using a Efektinom Depot cimetidine inhibits venlafaxine metabolism in the “first pass” through the liver, but has no impact on the pharmacokinetic processes About – desmetilvenlafaksina, with all this in most cases occurs only nekordinalnoe increase in the overall pharmacological activity of venlafaxine and O – desmetilvenlafaksina (more pronounced in hepatic dysfunction and in the elderly).

When using venlafaxine did not affect the pharmacokinetics of imipramine and processes 2 – OH – imipramine, but increases AUC, Cmax, Cmin of desipramine by approximately 35% and the AUC 2 – OH – desipramine increased to 2.5 – 4.5 times, with all imipramine this has no effect on the pharmacokinetic parameters of venlafaxine and O – desmetilvenlafaksina.

When using Efektin Depot risperidone increases the AUC by 32%, but has no impact on the pharmacokinetic profile of the total active components (risperidone and 9 – hydroxyrisperidone).

When using Efektina Depot, and indinavir showed a reduction in indinavir AUC by 28% and decreased Cmax by 36% of indinavir. Indinavir with all this does not impact on the pharmacokinetic parameters of venlafaxine and O – desmetilvenlafaksina.

The simultaneous use of lithium products does not affect the pharmacokinetics of venlafaxine and O indicators – desmetilvenlafaksina in an equilibrium state, and venlafaxine did not affect the pharmacokinetic parameters of lithium.

Venlafaxine has no effect on the pharmacokinetic parameters of drugs with a high degree of binding to plasma proteins.

Venlafaxine is a weak inhibitor of CYP 2D6 enzyme system and does not inhibit CYP 3A4, CYP 1A2 and CYP 2C9 in vitro. Under conditions in vivo it is confirmed in studies with alprazolam, caffeine, carbamazepine and diazepam.

Venlafaxine (venlafaxine) side effects

The criteria for evaluating the frequency of side effects: often – more than 1%, sometimes – from 0.1 to 1%, often not – from 0.01% to 0.1%; very rarely – less than 0.01%.

Cardio – vascular system: often – arterial hypertension, hot flashes; sometimes – hypotension, postural hypotension, syncope, tachycardia; very rarely – change the interval QT, ventricular fibrillation, ventricular tachycardia (including ventricular flickering).

From the digestive system: often – decreased appetite, constipation, nausea, vomiting, dry mouth; sometimes – teeth grinding during sleep (bruxism), change in taste; changing functional liver samples, hepatitis.

From the hematopoietic system: sometimes – ecchymosis, bleeding from mucous membranes; not often – thrombocytopenia, increased bleeding time. With a frequency of unidentified occur agranulocytosis, aplastic anemia, neutropenia, pancytopenia.

On the part of metabolism: often – increase the level of cholesterol in the blood plasma (especially with prolonged use or when used in larger doses), weight loss; sometimes – hyponatremia, weight gain; not often – syndrome of inappropriate secretion of ADH.

From the central and peripheral nervous system: often – fatigue, weakness, nightmares, decreased libido, dizziness, increased muscle tone, insomnia, high anxiety, paresthesia, sedation, tremor, accommodation disturbances, mydriasis, visual disturbances; sometimes – apathy, hallucinations, myoclonus; rarely – seizures, mania, neuroleptic malignant syndrome, serotonergic syndrome.

With the genitourinary system: often – abnormal ejaculation, orgasm disturbance, anorgasmia, erectile dysfunction, impaired urination (males), sometimes – menorrhagia, orgasm disorders, urinary retention (in women).

Dermatological reactions: sometimes – rash, alopecia, photosensitivity.

Allergic reactions: very rarely – anaphylactic reactions, erythema multiforme, Stevens – Johnson.

Other: often – yawning, sweating.

Venlafaxine (Venlafaxine) release form

The tablets (blisters) 37.5 mg, 75 mg.

Venlafaxine (Venlafaxine) composition

The drug Efektin Depot contains (per capsule):

venlafaxine hydrochloride – 75 mg;

Other ingredients – 150mg.

Other ingredients: microcrystalline cellulose, ethyl cellulose, hydroxypropyl methyl cellulose, gelatin, yellow iron oxide, red iron oxide, titanium dioxide.

The ink composition for printing include: shellac, ethanol, isopropyl alcohol, n – butyl alcohol, propylene glycol, sodium hydroxide, polyvinyl pyrrolidone, titanium dioxide.

14 pcs. – Blisters (2) – packs cardboard.

Venlafaxine (Venlafaxine) during pregnancy

Venlafaxine (Venlafaxine) interaction with other drugs

Medicine synonym for Venlafaxine (Venlafaxine)

Effexor, phenethylamine, venlafaxine – hydrochloride, Efektin, Efektin Depot, Efectin, Efectin Depot

Venlafaxine (Venlafaxine) Additional information

Manufacturer: WYETH MEDICA IRELAND

Representation: Wyeth – Whitehall EXPORT Ges.m.b.H.

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