Last Updated on February 19, 2017 by Dr.Derek Fhisher
Most popular brand: Lincocin
Active ingredient: Lincomycin
Available dosage forms: 500 mg
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Lincomycin general information
Ask your wellbeing care provider if Lincomycin might interact with other medicines you take. Just like with any career, salary is important and pharmacist isn’t any exception. Ask your wellbeing care provider any questions that may have regarding how exactly to utilize Lincomycin. Terms may change from time to time so that it helps you to truly double-check with your provider on this particular issue just before treatment. Lincomycin is used for remedying serious infections brought on by certain bacteria. Deteriorating quality of life might cause emotional distress including indications of anxiety as well as depression.
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Blood, kidney or liver functions ought to be monitored on a normal basis as long as you’re on Lincocin. Intake of the medication needs to be divided by equal intervals to receive the very best benefit from it. All medicines can cause unwanted effects, but many have no, or minor, unwanted side effects. In case the trouble isn’t treated on a protracted stretch of time, it may cause serious complications including cancer. This is to prevent drug interactions which could either weaken the repercussions of Lincomycin or draw another group of side outcomes. Monitor your medicine cabinet commonly to view the rest of the variety of pills.
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Inform your doctor if you’re pregnant or intend on becoming pregnant during treatment. Your doctor, nurse, or alternative healthcare provider will provide you with this injection. You shouldn’t obtain this medication if you’re allergic to lincomycin or clindamycin (Cleocin). Follow your physician’s instructions. If it describes your client, you are going to want to utilize BOTOX. Use each disposable needle just one time.
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Description of the active ingredient Lincomycin / Lincomycin.
Formula: C18H34N2O6S, chemical name: (2S – trans) – methyl – 6,8 – dideoxy – 6 – [[(1 – methyl – 4 – propyl – 2 – pyrrolidinyl) carbonyl] amino] – 1 – thio – D – erythro – alpha – D – galacto – oktopiranozid (in the form of monohydrochloride)
Pharmacological group: Antimicrobial, antiparasitic, and sedative / antibiotics / lincomycin (. . lincosamides)
Mode of action: antibacterial.
Lincomycin inhibits protein synthesis of bacteria – for binding (reversible) with the 50S ribosomal subunit and violations of the formation of peptide bonds. Lincomycin is effective against gram-positive microorganisms (Corynebacterium diphtheriae, Streptococcus spp. Including Streptococcus pneumoniae, Staphylococcus spp.), A small portion of gram-negative anaerobes (Mycoplasma spp. Bacteroides spp.) And anaerobic spore-forming bacteria (Clostridium spp.). Lincomycin effect on microorganisms which are resistant to other antibiotics (especially Staphylococcus spp.). Are resistant to Lincomycin gram-negative bacteria, Enterococcus spp. (Including Enterococcus faecalis), fungi, protozoa, viruses. Erythromycin Lincomycin inferior in activity against Neisseria spp. spore-forming anaerobes, Corynebacterium spp.
Resistance to lincomycin and microorganisms develops slowly. Between clindamycin and lincomycin has cross-resistance. In therapeutic doses lincomycin bacteriostatic effect in higher organisms and highly anti – bactericidal. After oral administration on an empty stomach about 20-30% of the absorbed dose (food intake greatly reduces the bioavailability and absorption of the drug when using lincomycin after meal is 5%), the maximum blood concentration develops within 2-4 hours after ingestion. Lincomycin is rapidly and well distributed in many tissues and body fluids (except spinal cord – cerebrospinal fluid), high concentrations are created in the bone tissue and bile. Through the blood-brain barrier penetrating linkomitsin bad. Through the placenta and breast milk lincomycin passes. The liver is metabolized. In normal renal function, half-life is 4-6 hours, end-stage kidney disease at half-life of 10-20 hours increases, in violation of the liver elimination half-life increased by 2 times. In the form of metabolites and unaltered excreted by the kidneys and the bile. After oral administration in unchanged form excreted in the feces for 3 days, 30-40% of the dose. Hemodialysis and peritoneal dialysis for removal from the body of lincomycin are not effective.
The infectious – inflammatory diseases heavy currents, which are caused by susceptible microorganisms (mainly streptococci and staphylococci, particularly those microorganisms that are resistant to penicillin, and in case of allergy to penicillin): infections of the joints and bones (pyogenic arthritis, chronic and acute osteomyelitis ), otitis media, lower respiratory tract infections (including pneumonia and aspiration, pleural empyema, lung abscess), purulent soft tissue infections and skin (pyoderma, cellulitis, furunculosis, wound infection, erysipelas).
How to use and dosage of lincomycin
Lincomycin is used inside (2-3 hours after a meal or 1-2 hours before a meal, copiously with water), intramuscularly, intravenously, topically. The mode set individually, depending on the indication and the severity of the disease. Adults: ingestion of a single dose of 0.5 grams daily equals 1.5-2 g, for parenteral injection (intravenously or intramuscularly) single dose is 0.6 g equal to 1.8 g daily (dose can be increased up to 2 4 g of 3 injection intervals between doses 8 hours). Children between the ages of 1 month to 14 years: inside the daily dose is 30-60 mg / kg body weight (2-3 reception at intervals of 8-12 hours), parenterally is 10-20 mg / kg / day, regardless of age . If the patient has a renal and / or liver failure, when administered parenterally lincomycin daily dose should not be more than 1.8 g, and the intervals between doses should be 12 hours. The local use of lincomycin is applied to the affected skin as a thin layer 2-3 times a day.
When you pass another receiving lincomycin take it as remember the following method through produce a set time of last use.
Not lincomycin should be combined with muscle relaxants. In severe infections lincomycin should be combined with aminoglycosides or other antibiotics that act on Gram-negative bacteria. Appointment linkomitcina patients who have liver failure, is permissible only for health reasons. With prolonged use of lincomycin requires systematic monitoring of renal function and liver. In the case in patients receiving lincomycin developing pseudomembranous colitis, his reception was stopped and the prescribed bacitracin or vancomycin. No quick intravenously administered lincomycin. When local use must be careful when ringworm.
Hypersensitivity, age 1 month, severe renal and / or hepatic impairment.
Restrictions on the use
Fungal disease of the mucous membranes of the vagina, mouth, skin; myasthenia gravis (for parenteral use, extra).
Pregnancy and breastfeeding
linkomitcina Admission is contraindicated during pregnancy (except in cases where the use of lincomycin is necessary for health reasons). At the time of lincomycin treatment must stop breastfeeding.
Side effects of lincomycin
hematopoiesis: reversible leukopenia, neutropenia, thrombocytopenia; Digestive system: nausea, abdominal pain, diarrhea, vomiting, stomatitis, glossitis, transient hyperbilirubinemia, increased activity of hepatic transaminases, with prolonged use – candidiasis gastro – intestinal tract, pseudomembranous enterocolitis, antibiotic diarrhea; allergic reactions: exfoliative dermatitis, urticaria, anaphylaxis, angioedema; Other: local reactions when administered intravenously – phlebitis; the rapid introduction intravenously – dizziness, low blood pressure, relaxation of skeletal muscles, fatigue.
linkomitcina Interaction with other substances
Perhaps the development of antagonistic action when used lincomycin with erythromycin, ampicillin, chloramphenicol, and other bactericidal antibiotics, synergistic action when used together with aminoglycosides lincomycin. Antidiarrhoeal drugs reduce the effects of lincomycin (the interval between the use of lincomycin and antidiarrheal agents must be at least 4 hours). Lincomycin increases the impact of drugs for inhalation anesthesia, opioid analgesics and muscle relaxants, increasing the possibility of the development of neuro – muscular blockade and respiratory arrest. Lincomycin pharmaceutically incompatible with novobiocin or kanamycin and ampicillin, theophylline, barbiturates, calcium gluconate, magnesium sulfate, and heparin.
No data. In the case of overdose lincomycin may increase side effects. Needed symptomatic therapy. Lincomycin is not removed from the body during hemodialysis and peritoneal dialysis. Prolonged use of lincomycin may develop candidiasis gastro – intestinal tract, pseudomembranous enterocolitis, in the case of the latter it is necessary to cancel an appointment linkomitcina.
Trading names of drugs with working substance linkomitsin
Lincomycin Lincomycin – Akos
Linkomitsina hydrochloride capsules 0.25 g
Linkomitsina hydrochloride injection 30%
Neloren® films with lincomycin