Last Updated on October 18, 2021 by Dr.Derek Fhisher
Most popular brand: Rythmol
Active ingredient: Propafenone
Available dosage forms: 150 mg
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Propafenone general information
Propafenone – effective antiarrhythmic agent for ventricular and certain supraventricular tachyarrhythmias: ventricular premature beats, paroxysmal ventricular tachycardia, supraventricular tachycardia, atrial fibrillation, the atria, “re – entry” tachycardia, Wolff – Parkinson – White (WPW – syndrome) .
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Children Propafenone can lead to serious unwanted side effects in virtually any patient. Propafenone is used in some specific situations to stop serious heart rhythm disorders. For this reason, it is especially important that you discuss with the kid’s doctor the good this medicine might do too as the dangers of utilizing it. On account of the potential for issues in the nursing infant, propafenone is usually not endorsed in mothers that are breast-feeding. Inform your doctor in case you are pregnant or intend on becoming pregnant whilst using this medication. These certifications make certain you can shop at ease and know you’re shopping with a reliable online pharmacy where you could find the bottom price on Propafenone or another medication you might need.
Prior to taking propafenone, be sure that your doctor knows if you’re pregnant or if you might become pregnant. Inform your doctor if you smoke. Ask your physician about this. Take propafenone completely as instructed by your doctor. Be certain your doctor knows if you hold a pacemaker. Call your physician for medical advice regarding side effects.
Dosage is dependent on your healthcare condition and response to treatment. Your own doctor will review your progress along with the effects of the medicine at regular visits. Your own doctor may improve your dose if necessary. This medicine might cause you to get dizzy or drowsy. These problems can adjust the mineral levels in your own blood and result in side effects from using this medicine. This medicine might decrease the total amount of sperm men make.
Order Propafenone or some other product from our large collection of medication online twenty-four hours a day, seven days a week. You won’t have the capacity to get PROPAFENONE without a prescription by means of this website. Perform a cost comparison on the page to view the difference in price. You can find generic Propafenone knowing you’ll get the exact quality and stamina as the brand name Propafenone. There might be other brands for this particular medicine. This information includes only the typical doses of propafenone.
If you’re able to, avoid individuals who are sick. Have a dose when you remember. To assist you remember, take it at the exact same times every day. Keep from the reach of children. This helps keep one’s heart rhythm normal. You might need to carry identification stating that you’re using propafenone.
In deciding to employ a medicine, the dangers of taking the medicine must certanly be weighed against the good it’ll do. In such cases, your personal doctor may want to alter the dose, or alternative precautions might be necessary. Ask your pharmacist any questions that might have concerning this medication, particularly in case that it’s new to you personally. There are various other drugs that could interact with propafenone. In case the disturbance within the heart rhythm straight from the ventricle out should just be used Propafenone, once the situation is life-threatening. This particular product might not be secure, appropriate or effective for you.
Since it’s been shown to cause severe troubles in certain patients, propafenone is simply used in the treatment of serious heart rhythm troubles. Inform your doctor in the event your condition will not improve or whether or not it worsens. We also provide a prescription transfer services.
Propafenone is a highly Ic antiarrhythmics class classification V.Williams, sodium channel blocker with b – adrenoblokiruyuschey ability)
Propafenone causes a decrease in the excitability of cells heart muscle and cardiac conduction slowing through its direct effect on the cells. Propafenone, blocking the fast sodium channel causes a dose-dependent decrease in the rate of depolarization and “overshoot” (inhibits phase G) of the building and its amplitude. Therefore, slowing down in the atrium, AV – node along the beam of His and the Purkinje fibers.
The blockade of sodium channels, which develops during each action potential and partly fading (reduction of unit) during diastole, increases with an increase in heart rate ( “frequency-dependent” block). When using propafenone is a significant lengthening of the interval P – Q and expansion of the complex QRS, and – intervals of Sciences ( “atrium – a bundle branch block”) and the HV ( “bundle of His – ventricle”). Slowing holding the drug prolongs the effective refractory period in the atria, the atrioventricular node in in other beams and to a lesser extent in the ventricles. Nor is there any – any significant changes in the range of Q – T. These effects appear on the electrocardiogram curve.
Propafenone is an effective anti-arrhythmic agent for the prevention and treatment of certain pathological acceleration of heart rate (tachycardia).
Propafenone is highly effective for the prevention and treatment of all forms of ventricular arrhythmias, supraventricular rhythm disorders when efficiency is slightly lower. Patients with additional conductive paths propafenone prolongs the refractory period in these ways, completely blocking conduction in any direction.
Propafenone has expressed weakly beta – adrenoceptor blocking action. In ordinary doses does not cause a statistically significant effect on the strength of contraction of the heart or blood pressure.
- ventricular arrythmia;
- paroxysmal ventricular tachycardia (severe and life-threatening ventricular tachycardia symptomatic);
- supraventricular tachycardia;
- atrial fibrillation, prevention of relapses;
- atrio – ventricular “re – entry” tachycardia (AV – junctional tachycardia);
- recurrent supraventricular tachycardia, including when syndrome Wolff – Parkinson – White (WPW – syndrome).
Propafenone is used intravenously and inside. The dosage and treatment regimen selected individually, with ECG – monitoring and control of blood pressure.
During dose adjustment, and maintenance therapy daily dose is 300 – 600 mg (150 mg of 2 – 3 times a day); the maximum daily dose – 900 – 1200 mg in 3 divided doses at regular ECG monitoring.
The tablets should be taken after meals, not liquid, squeezed small amounts of liquid. These data are valid for patients with a body weight of about 70 kg. With less weight daily dose should be reduced accordingly.
Intravenous injection should be administered slowly over 3 – 5 minutes.
A single intravenous dose of 1 mg / kg body weight. Effect appears frequently already at a dose of 0.5 mg / kg body weight. If necessary, a single dose can be increased to 2 mg / kg.
In short infusion (1 – 3 hours) drug is given in a dose of 0.5 – 1 mg / min. 5% glucose solution or levulose.
If continuous infusion is sufficient daily dose of 560 mg.
- symptomatic heart failure (III – IV FC by NYHA);
- cardiogenic shock (except arrhythmogenic shock);
- severe hypotension;
- sick sinus syndrome (syndrome “tachycardia – bradycardia”);
- conduction disturbances (sinoatrial, atrioventricular and intraventricular);
- In the first 3 months after myocardial infarction;
- The expressed disturbances of electrolyte balance;
- severe chronic obstructive pulmonary disease;
- myasthenia gravis;
- for women during pregnancy and lactation.
Use during pregnancy and lactation:
During pregnancy, especially in the first 3 months, and during lactation taken only under strict indications.
Perhaps proaritmogennoe action, orthostatic hypotension, increased heart failure, there may be diarrhea disorders (disorders of appetite, nausea, vomiting), dizziness, headache, blurred vision, disturbance of taste sensations (bitter taste and numbness in the mouth), fatigue, anxiety, and sleep disorders. Very rare hepatic jaundice. With the possible occurrence of adverse effects of the drug should immediately inform your doctor!
Special instructions and precautions:
With the expansion of QRS interval of more than 20%, or long QT time is necessary to reduce the dose or stop the drug to normalize the ECG.
Long-term drug treatment can change the “pacing” and “sensing” pacemaker thresholds. The function of the artificial cardiac pacemaker should be re-checked and re-programmed as required.
Be sure to inform your dentist or doctor – a surgeon that taking the drug propafenone.
With the simultaneous use of propafenone with beta – blockers, tricyclic antidepressants may increase the antiarrhythmic action of propafenone.
The drug may potentiate the action of anticoagulants.
In a joint application Propafenone may increase the blood concentration of propranolol and metoprolol as cyclosporin A and digoxin.
Reduced propafenone effects observed with concomitant use of phenobarbital and rifampin as well.
When concomitantly with cimetidine marked increase propafenone plasma levels.