Last Updated on February 19, 2017 by Dr.Derek Fhisher
Most popular brand: Priligy
Active ingredient: Dapoxetine
Available dosage forms: 60 mg
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Dapoxetine general information
A new drug, generally known as dapoxetine Priligy is, in addition, obtainable in certain countries for your own treatment of premature ejaculation, plus it would be wise to seek advice from your physician for far more guidance. Those suffering from low or significant blood pressure, kidney as well as heart problems need to be careful when using them. In addition, dapoxetine really should not be taken more than once in one day, particularly if you need to avert any side results and to make certain the drug works. If you really would like to get dapoxetine and also to find a lot more about this medicine, online you’ll come across each of the information you’ll need!
While considering different treatments, Traditional Chinese medicine has ever given a massive amount of consideration to men’s health and assorted problems connected with it. In a few countries however, a fresh prescription drug called Priligy dapoxetine was approved for healing premature ejaculation in men. That’s the reason, there’s such a variety of Chinese herbs that are traditionally prescribed for healing rapid ejaculation. Nonetheless, men who want to boost the duration of sex and boost their sex life should truly buy dapoxetine.
In short, any woman who’s habitually dirty will definitely repel men. It’s not only embarrassing for them, but it could also make problem inside their love relationship. Consequently, both partners don’t experience satisfaction from mutual intercourse. They snub men anytime they’re approached.
The great news for men who want to buy dapoxetine is the fact that online they’ll discover numerous providers that provide dapoxetine at quite competitive rates. Men who want to buy dapoxetine can pick from generic and brand dapoxetine. I purchased the item, and reluctantly I need to say that it worked. The branded drug is a little more expensive and it’s offered in a certain color and packaging as the generic is more accessible from a financial viewpoint and widely offered.
Now, individuals are facing lack of sexual stimulation because of excessive stress on the job. You may well be asked to prevent intercourse for a while and focus on other sorts of sexual activities to knock out stress out of sex. They might also avoid or drop interest in sex. The drug begins to work only 3 hours following the dosage.
Impotence, is certainly a various tale when compared with premature ejaculation. It raises the sexual appeal and in addition prolongs the sexual intercourse. That’s the reason, there’s such a wide variety of Chinese herbs that are traditionally prescribed for healing premature ejaculation. Biological factors that might cause premature ejaculation in men incorporate abnormal hormone levels, thyroid issues, neurological or vascular troubles and abnormal rates of neurotransmitters within the brain. While you’ll find a handful of elements that could lead to premature ejaculation.
Priligy dapoxetine is a prescription drug to take care of ejaculation issues in men of 18 decades or older. Most men and women visit their pharmacy a minumum of one time a month, so convenience is frequently a superior thing. To discover more about impotence issues, priligy or maybe to read breaking health news, go to the blog. Unless they can be tested and treated, they are able to transmit it to others. A few of the comments could be reprinted elsewhere within the site and in the newspaper. You may get website links below to discover more about both these exams.
Most men and women visit their pharmacy no less than a month, so convenience is truly an excellent thing. For example, in case you’ve been referred to a shop from your no-name link on the web, it’s the signal you need to be more careful. Two, it might be an environmental link. Probably the property game isn’t too difficult after all. They add a very good level of variety to the standard run and gun gameplay style regular of the set. You simply get slightly hopeless and when you receive the possibility to work again it truly is perfect because you feel that you’re important again.
Premature ejaculation is some of those important sexual issues that will hinder an individual’s romantic endeavors. The issue of coming too soon is experienced by nearly all adult men sooner or later inside their lives, however it is PE when lose control on your ejaculatory reflex and start shooting off in only a minute or so after penetration. He rarely misses a snap at practice, and it has missed just a single game within the previous eight seasons. A serious fault” was found in a single wing, based on the president. I’d have hoped to address that situation slightly better.” I’ve just gotten so utilised to simply everything relating to this tournament.”
There was always a particular quantity of pride. In all honesty, I was quite surprised because in my mind, construction work has at all times been work for men. I’ve also learned that no app could ever be like a real-life meteorologist. He just wishes to do his job. There haven’t been any missteps. I’m sure they’ll obtain their way.
Dapoxetine – instructions for use, real counterparts and release form (tablets 30 mg and 60 mg) of the drug for the treatment of premature ejaculation in men and enhance potency. The composition and the interaction with alcohol
In this article, you can read the instructions for use of the drug Dapoxetine. Presents reviews of visitors – users of the drug, as well as opinions of doctors skilled in the use Dapoxetine in their practice. Most requested actively add their own reviews of the preparation: helped or did not help to get rid of the medicine from the disease, which were observed complications and side effects may not be claimed by the manufacturer in the summary. Analogs or generic Dapoxetine in the presence of the available structural analogues. Use for the treatment of premature ejaculation in men and enhance potency. The composition and interaction of the drug with alcohol.
Dapoxetine – the mechanism of action of the drug in premature ejaculation is associated with the inhibition of serotonin reuptake by neurons followed by amplification action of the neurotransmitter in the pre – and post-synaptic receptors. ejaculation mechanism mainly regulated by the sympathetic nervous system. Postganglionic sympathetic nerve fibers innervate the seminal vesicles, vas deferens, prostate, urethra, and muscles of the bladder neck, causing them to reach a coordinated reduction in ejaculation. Dapoxetine affect the ejaculation reflex, increasing latency and reducing the duration of reflex impulses ganglia motoneurons crotch. The stimulus that triggers ejaculation, generated in the spinal reflex center, which through the brain stem is controlled by several brain nuclei, including the preoptic and paraventricular.
+ Dapoxetine auxiliaries.
Dapoxetine is rapidly absorbed and the maximum plasma concentration (Cmax) is achieved after 1 – 2 hours after ingestion. Eating fatty moderately reduces Cmax dapoxetine (10%) and a 12% increase in AUC, and time to reach maximum plasma concentration. However, the extent of absorption of dapoxetine is not changed. These changes are not clinically significant. The drug Dapoxetine can be taken regardless of meals. More than 99% of dapoxetine is bound to plasma proteins. The active metabolite – dezmetildapoksetin – bound to plasma proteins at 98.5%. Dapoxetine is rapidly distributed throughout the body with a mean volume of the equilibrium distribution of 162 l.
Studies suggest that dapoxetine is metabolized by a number of enzymes of the liver and kidneys, especially CYP2D6, CYP3A4 and flavin – containing monooxygenase (FM01) kidney. In a clinical study, during which studied the metabolism of 14C – dapoxetine, dapoxetine after oral administration is actively metabolized mainly through of N – oxidation, of N – demethylation, hydroxylation naphtho – groups, and glucuronidation joining sulfo – group. After oral administration detected a first pass metabolism in the liver. The main components in circulating blood plasma were intact and dapoxetine dapoxetine – N – oxide. The studies found that dapoxetine – N – oxide activity. Furthermore, and didezmetildapoksetin dezmetildapoksetin detected in an amount less than 3% of the total circulating metabolites of dapoxetine. The study found that by dezmetildapoksetin activity comparable with dapoxetine and didezmetildapoksetin approximately 2 times less potent than dapoxetine. The exposure (AUC and Cmax) of unbound dezmetildapoksetina was 50% and 23% of the unbound dapoxetine respectively.
The metabolites of dapoxetine are derived mainly in the urine as conjugates. The unmodified active substance in urine is detected. Dapoxetine is rapidly eliminated, as evidenced by the low concentration of the substance in the blood plasma (less than 5% of the maximum) at 24 hours postdose. With a daily intake substance accumulation in the body is minimal. When taken orally during the final half-life of about 19 hours.
A single dose of dapoxetine 60 mg showed no significant differences in pharmacokinetic parameters in healthy elderly men and men younger.
- for the treatment of premature ejaculation in men aged 18 to 64 years (a reflex increase in potency due to prolonged intercourse and increasing confidence).
Film-coated tablets 30 mg and 60 mg.
Instructions for use and dosage regimen
For the oral administration. Tablets should be swallowed whole, washed down with at least one full glass of water. The drug Dapoxetine can be taken regardless of meals.
The recommended starting dose for all men is 30 mg; take this dose for 1 – 3 hours before the intercourse. With little effect and good tolerance dose of 30 mg can be increased to 60 mg. The maximum recommended dosing frequency – 1 time in 24 hours.
The doctor who prescribed the drug Dapoxetine for the treatment of premature ejaculation, must assess the risks and benefits of the drug after the first 4 weeks of treatment or after administration of 6 doses and should determine the ratio of the risk – benefit to the decision on whether to continue treatment with Dapoxetine
- unusual dreams;
- a state of euphoria;
- mood swings;
- sleep disorders;
- loss of libido;
- impaired concentration;
- syncope, including vasovagal syncope;
- postural dizziness;
- depression of consciousness;
- blurred vision;
- pain in the eyes;
- sinus bradycardia;
- BP reduction;
- systolic hypertension;
- stuffy nose;
- nausea, vomiting;
- diarrhea, constipation;
- abdominal pain;
- dry mouth;
- a cold sweat;
- erectile dysfunction;
- the absence of ejaculation;
- orgasm disturbance, including anorgasmia in men;
- paresthesia genitals of men;
- hot flashes;
- the feeling of intoxication.
- hypersensitivity to dapoxetine or any subsidiary component of the drug;
- expressed heart disease (eg, heart failure, 2 – 4 class NYHA, disturbances of cardiac conduction (the AV – block 2 – 3 degrees or sick sinus syndrome (SSS)) in the absence of a permanent pacemaker, severe coronary artery disease or failure valvular) ;
- simultaneous reception of MAO inhibitors and acceptance within 14 days after the termination of their application. Likewise, MAO inhibitors should not be taken within 7 days after stopping the drug Dapoxetine;
- simultaneous reception of thioridazine, and within 14 days after the termination of its use. Similarly, thioridazine should not be taken within 7 days after stopping the drug Dapoxetine;
- simultaneous reception of serotonin reuptake (selective serotonin reuptake inhibitors – SSRIs) inhibitors, inhibitors of the reuptake of serotonin and norepinephrine, and tricyclic antidepressants), and other drugs with serotonergic activity (for example, of L – tryptophan, triptans, tramadol, linezolid, lithium , drugs St. John’s wort (Hypericum perforatum) and within 14 days after discontinuation of these drugs Similarly, these drugs should not be taken within 7 days after stopping the drug Dapoxetine;.
- simultaneous reception with active inhibitors of CYP3A4, such as ketoconazole, itraconazole, ritonavir, saquinavir, telithromycin, nefazodone, nelfinavir, atazanavir, etc;.
- moderate and severe hepatic dysfunction;
- severe renal dysfunction;
- children and adolescents younger than 18 years;
- lactose intolerance.
- mild to moderate renal impairment;
- simultaneous application of potent inhibitors of CYP2D6 isozyme CYP3A4 inhibitors and moderate patients with genotype CYP2D6 isozyme low activity and patients with high activity isoenzyme CYP2D6 (in combination with moderate inhibitors isoenzyme CYP3A4);
- simultaneous use with drugs that affect platelet aggregation and anticoagulants from – the risk of bleeding
Application of pregnancy and breastfeeding
The drug Dapoxetine is not intended for use in women.
Based on the limited amount of data obtained in clinical trials, there is no reason to assume that taking dapoxetine man can affect pregnancy partner. Well-controlled studies of the use of dapoxetine in pregnant women is not carried out.
It is not known if dapoxetine is displayed and its metabolites in breast milk.
Use in children
The drug Dapoxetine should not be taken in patients younger than 18 years.
Use in elderly patients
A single dose of dapoxetine 60 mg showed no significant differences in pharmacokinetic parameters in healthy older men (over 65 years) and men younger.
The drug Dapoxetine is only for men with premature ejaculation. The safety of the drug in men without premature ejaculation has not been established, on the delay ejaculation no data.
A randomized, double-blind, placebo – controlled study confirmed the effectiveness of Dapoxetine for the treatment of premature ejaculation (PE). Dapoxetine 60 mg significantly improves the average delay time intravaginal ejaculation (IELT) compared to the 30 mg dapoxetine in men with PE lifetime, but there is no difference in men with acquired PE. Dapoxetine increases the sense of control and sexual satisfaction in men 18 to 64 years with PE.
Reception with drugs
Patients should be advised not to take the drug with Dapoxetine drug. Simultaneous treatment with the drug Dapoxetine drugs having serotonergic activity such as ketamine, methylenedioxymethamphetamine (MDMA) and lysergic acid diethylamide (LSD) may lead to potentially serious reactions, including, but not limited to, arrhythmia, hyperthermia, and serotonin syndrome. Admission Dapoxetine drug in conjunction with sedatives such as opiates or benzodiazepines may increase drowsiness and dizziness.
The combination of the drug Dapoxetine with alcohol may increase the effects of the latter on the central nervous system and neuro – cardiogenic side effects of alcohol, such as syncope, thereby increasing the risk of accidental injury. Therefore, patients should be advised to abstain from alcohol while taking Dapoxetine.
The frequency of syncope in the clinical trials of the drug Dapoxetine depend on the category of patients and ranged from 0.06% (for a dose of 30 mg) to 0.23% (for a dose of 60 mg) to 0.64% (for both doses together ) in a study involving healthy volunteers.
In patients receiving the drug Dapoxetine, compared with patients receiving placebo, were more common prodromal symptoms, including nausea, dizziness / feeling of lightheadedness and sweating. At a dose of the drug Dapoxetine 30 mg the incidence of nausea was equal to 11.0%, dizziness rate – 5.8%, hyperhidrosis – 0.8%. At a dose of 60 mg Dapoxetine formulation these figures were 21.2%, 11.7% and 1.5% respectively. The frequency of syncope and possible prodromal symptoms was dose-dependent, as evidenced by higher rates in patients who received higher doses than the maximum recommended daily dose of 60 mg. The observed in clinical studies, cases of syncope were regarded as having a vaso – vagal nature. Most of these cases occurred within the first 3 hours after the first dose, or were related to the study procedures in the clinical setting (eg, taking a blood sample, a sharp build-up, measurement of blood pressure). Possible prodromal symptoms, such as nausea, dizziness, lightheadedness, palpitations, asthenia, confusion and sweating, usually also observed in the first 3 hours after dosing, and often preceded the syncope. Patients should be informed that during the period of treatment with Dapoxetine may at any time of syncope with or without prodromal symptoms are. The physician should inform the patient about the importance of adequate water load and of recognizing prodromal signs and symptoms to reduce the risk of serious injury from a fall – due to loss of consciousness. When possible prodromal symptoms the patient should immediately lie down so that the head was lower torso, or sit down with his head between his knees, and must remain in this position until symptoms disappear. In case of fainting or other effects on the central nervous system of the patient should be warned about the need to avoid a potentially traumatic situations, including driving and control of dangerous machinery.
The combination of Dapoxetine drug with alcohol may enhance the neuro – cardiogenic side effects, including fainting, which increases the risk of accidental injury; therefore, patients should be advised to abstain from alcohol during treatment with Dapoxetine.
Patients at risk of cardio – vascular diseases
Patients with heart did not participate in clinical trials of the drug – vascular diseases. In patients with organic diseases of the heart and blood vessels (such as obstruction of the ejection of blood from the heart, valvular lesions, carotid artery stenosis, atherosclerosis, coronary artery disease), increased risk of adverse cardio – vascular effects of syncope and other cardiac origin. However, there is currently insufficient data to determine whether this risk extends to vaso – vagal syncope in patients with cardio – vascular diseases.
cases of orthostatic hypotension are described in the clinical studies. The physician must advance to inform the patient that when a potential prodromal symptoms, such as ease of feeling in the head immediately after getting up, immediately lie down so that the head was lower torso, or sit down with his head between his knees, and remain in this position until symptoms disappeared. In addition, it is necessary to inform the patient of the need to avoid sudden getting up after prolonged lying or sitting. Also, Dapoxetine drug should be used with caution in patients receiving vasodilators (eg, alpha – blockers, nitrates, PDE5 inhibitors), because – for the possibility of reducing the tolerance of patients to orthostatic effect of the drug.
moderately active inhibitors of CYP3A4
When taking Dapoxetine drug simultaneously with moderately active inhibitors of CYP3A4 (erythromycin, clarithromycin, fluconazole, amprenavir, fosamprenavir, aprepitant, verapamil, diltiazem), the dose should be reduced to 30 mg, caution should be taken.
active inhibitors of CYP2D6
It is recommended to exercise caution when increasing the dose of the drug Dapoxetine 60 mg in patients receiving active CYP2D6 inhibitors, and in patients with low activity of CYP2D6, as this may increase the level of systemic exposure of the drug to a corresponding increase in the frequency and severity of dose-dependent adverse events.
In short-term studies of antidepressants, including SSRIs, compared with placebo, greatly increases the risk of suicide and the emergence of suicidal ideation in children and adolescents with generalized depression and other mental disorders. In adults over 24 years found no such effect. In clinical studies, the drug Dapoxetine is not obtained for the treatment of premature ejaculation clear data about suicidal thoughts due to the treatment.
The drug Dapoxetine is impossible to accept patients with a history of mania / hypomania or bipolar disorder, with symptoms of these diseases the drug should be discontinued.
From – the ability of SSRIs to lower the seizure threshold should be avoided if the drug Dapoxetine patients with unstable epilepsy, convulsions when a drug should be discontinued. For patients with controlled epilepsy requires careful monitoring.
Related Depression and mental disorders
If the patient has signs and symptoms of depression before the start of the drug Dapoxetine is necessary to conduct a survey to exclude the presence of undiagnosed depressive disorders. The drug Dapoxetine should not be taken with antidepressants, including SSRIs and serotonin reuptake inhibitors and norepinephrine. It is not recommended to stop the treatment of depression or anxiety to start treatment with Dapoxetine. The drug Dapoxetine is not intended for the treatment of psychiatric disorders (eg, schizophrenia or depression), it should not take men with these diseases, because it is impossible to exclude the gain of depressive symptoms.
The structural analogs of active material:
In the absence of drug analogs of active material, it is possible to follow the links below on the disease, which makes it an appropriate drug and see the existing analogues for therapeutic impact.