Last Updated on February 19, 2017 by Dr.Derek Fhisher

Glucophage Metformin 500, 850, 1000 mg
Most popular brand: Glucophage
Active ingredient: Metformin
Available dosage forms: 500, 850, 1000 mg
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Metformin general information

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Current treatments include anti-inflammatory and immunosuppressive drugs. They’ve also been utilized to induce remission in a single study and were very profitable. A bigger study was performed four decades later.

Actually there are a number of promising non pharmaceutical treatments available today which haven’t any side effects and may keep colitis at bay by lowering inflammation naturally. These developments are frequently the result of the diet low in fiber. Meanwhile, it appears reasonable to put in a fantastic probiotic, such as EndoMune, to a daily regimen of the high-fiber diet to stop diverticulitis.

Treatment of diverticulitis depends upon the seriousness of the episode. In severe cases surgery might be performed. At times, surgery must remove the inflamed colon. It is really an inflammation occurring after an ileo-anal pouch surgery.

It is often proposed the microscopic colitis around a diverticulum is owing to a change within the intestinal bacteria or microflora. The alteration within the microflora leads to a chronic inflammation that may lead to diverticulitis (4). The results have demonstrated that probiotics appear to lessen recurrent episodes (4,5,6). It really is characterized by chronic inflammation within the massive intestine, which results in bloody diarrhea, cramping and a broad loss of life quality.

All medicines can cause negative effects, but many have no, or minor, unwanted effects. Also, don’t stop taking this medicine without first consulting your doctor.Keep taking this medicine for the entire time of cure, even if you start to feel better following a few days. In the event your dose differs, don’t change it unless your own doctor directs you to do so.The quantity of medicine you take is contingent on the strength of the medicine.

For those who have questions regarding side effects, get in touch with your health care provider. Call your physician for medical advice regarding side effects. Simply Take this medicine completely as instructed by your doctor. This information includes only the typical doses of the medicine.

All about the drug Metformin


Metformin has repeatedly confirmed the reputation of an effective anti-diabetic agents. The active agent formulation passing through complicated chemical reaction, reduces the amount of glucose in cells. In patients with diabetes mellitus, metformin ( is the name the active substance medications ) does not cause hypoglycemia. because it does not activate the action of insulin.

The drug decreases the amount of insulin in the blood and reduces appetite in patients, increases the burning of fat ( lipolysis ). “Elevated” insulin in the blood of diabetics is the cause of weight gain and the occurrence of cardiovascular disease.

Metformin is often used along with insulin, because it increases the sensitivity of insulin receptors, and does not allow the body to convert stored energy into fat. Here is the latest feature of the drug is widely used in sports. Athletes using Metformin like to keep fit – «dry» ( as it is called in the sports slang ).

One of the studies showed that the use of this medication seriously reduces the risk of pancreatic cancer.

Release Form

dosage tablets of 500 and 850 mg.


1. Diabetes . Especially recommended to use the drug in patients with higher weight. This drug reduces the risk of complications. The mortality rate when using Metformin decreased by 30% compared to other antidiabetic drugs. No wonder it is considered the drug of choice for this disease.

If you have diabetes medication adverse events can be hyperglycemia, but it occurs much less frequently than with other drugs.

2 prediabetes -. It is a condition in which an increased risk of developing diabetes. Metformin in combination with diet and exercise wellness avoids transfer of the patient to the diabetic stage..

3 Polycystic Ovarian Syndrome – occurs when hormonal disorders in women. Metformin for this disease is a good therapy if the patient has impaired glucose tolerance. Also, it is used in some other female diseases, such as anovulation ( breach menstrual cycle)..

4 Gestational diabetes – this disease in pregnant women. The disease is in violation of carbohydrate metabolism. The cause of gestational diabetes – change during pregnancy hormones. The drug proved to be excellent in the treatment of this disorder.

Risk factors for the appearance of “pregnant” Diabetes: late delivery. interrupted before pregnancy, heavy gynecological history. a lot of weight.


  • Kidney disease. liver. lungs.
  • Myocardial infarction.
  • Ketoacidosis ( disease, which interferes with carbohydrate metabolism of the – due to lack of insulin )
  • .

  • Dehydration.
  • lactic acidosis ( a disorder in which a large amount of lactic acid accumulates in the blood and tissues).
  • low-calorie diet ( up to 1000 calories per day ).

Before the radiographic examination with the introduction of iodinated contrast agent, a drug, it is desirable to cancel. The contrast agent may adversely affect kidney function and cause a delay in drug in the body.

If pregnancy should be prescribed the drug only for objective reasons, when the use of it may exceed the potential harm to the fetus.

Older people are also prescribed medicine with caution.

Side Effects

The drug may adversely affect the digestive tract and cause diarrhea. To stop the diarrhea. Metformin is necessary to reduce the dosage. At a dose of 1500 mg is usually no side effects occur even in children.

Women are often nausea occurs on a background of taking the medicine. In some individual cases, patients feel strange “metallic” taste in the mouth.

More than a heavy adverse events related to the fact that the drug inhibits the secretion of insulin by the pancreas. The severity depends on the dosage.

The high dosage can cause hyperglycemia ( increase the level of glucose in the the blood), this is due to the property of the drug to keep glucose without letting it penetrate into the cells. Hyperglycemia and follow her hyperglycemic coma can be fatal, if time does not help. To prevent hyperglycemia should be regular in order to control blood glucose. If its level increased, the preparation course is interrupted for a few days, and insulin is administered subcutaneously alone – twice.

If you only use Metformin without concurrent use of other drugs, then after a certain time, you may receive spillover weakness and lethargy, drowsiness. This is due to the action of metformin substance which lowers the level of glycogen in liver and muscles. Glycogen – a reserve of energy, from which, if necessary, it produces glucose. To remove the sluggish state and sleepiness can make insulin injection.


drug overdose is extremely rare. In children with a dosage of up to 1700 mg of symptoms of intoxication is not observed.


  • The feeling of nausea, sometimes – vomiting
  • .

  • Abdominal pain.
  • Drowsiness.
  • rapid pulse.

The main risk of overdose – offensive lactic acidosis. The symptom is that the state of abdominal pain and muscle pain, fever. rapid breathing, dizziness. sometimes – loss of consciousness. In these cases need urgent hospitalization.

During the therapy with metformin should be regular monitoring of the functioning of the kidneys. If any problems with the kidneys – to abandon the drug. Every six months it is desirable to define the amount of lactate ( lactic acid ) in the plasma.


Oleg E., 46 years.
Doctors diagnosed with Pre-Diabetes, with the passing of risk in diabetes and insulin-dependent form. Assigned the whole complex – and medicines, and diet and physical. exercises. Several months later, health was much better, thinner, and diagnostics showed that the glucose level fell slightly. He began to learn from the doctor, what kind of weight loss drugs has contributed to the 98 kg to 86 turns, so Metformin acts. So far, I have appointed the continuation of a course of the drug. I believe that Pre-Diabetes will completely disappear!

Alya, 17 years,
I have problems with the ovaries -. Was diagnosed « polycystic ». Assigned the drug to the weight and slightly lower, and awaken ovulation. Subsequently had to give it up, as always sick. Polycystic I was very neglected, apparently, so I did not help treatment..

Elizabeth, 31 years old
In order to restore ovarian function assigned me Siofor ( on – to another it is called Metformin ). But I noticed that became thin. I read the information, I realized that losing weight from this medication. I am already very thin, and I do not want to lose weight on. Therefore I requested the doctor to replace me medicine to another.

Vladimir, 21 years.
We have found diabetes wife. She is 4 months pregnant. The doctors decided that she should assign this tool. Now she takes it, and we hope that he will help her. At least, she began to drink these pills, and blood glucose level does not jump. The doctor warned that the drug is generally not dangerous for the future of the child, but, nevertheless, made him cautious and is now constantly being control.

Before use, consult with a specialist.

Author:. Radzikhovskiy A. A

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