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Most antidepressant side effects are not harmful, but they might be bothersome. Here is what to do.


Antidepressants may cause side effects that are unpleasant. Symptoms and signs like nausea, weight reduction or sleep problems can be frequent. Within months of starting an antidepressant, these enhance for a lot of individuals. In some cases antidepressants cause unwanted effects which don’t move away.

Speak with your physician or health professional about any side effects you are having. For many antidepressants, blood glucose that are tracking might help also to what extent dose can be corrected to help decrease side effects and determine the selection of efficacy. Rarely, antidepressants may cause side effects which have to be treated straight away.

If side effects appear intolerable, you might be tempted to lower your dose or to stop taking an antidepressant. Do not do it. Your symptoms may go back, and quitting your antidepressant abruptly may cause symptoms. Speak to your physician determine the best options for your requirements.


Nausea usually begins after starting an antidepressant. It could go away after your body adjusts to the medicine.

Consider these strategies:

  • Require your antidepressant with meals, unless otherwise directed.
  • Eat smaller, more-frequent meals.
  • Suck on sugarless hard candies.
  • Drink lots of fluids, such as cool water. Try out an antacid or bismuth subsalicylate (Pepto-Bismol).
  • Talk with your physician about a dose switch or a slow-release type of the medicine.

Increased appetite, weight gain

You can gain weight because of absence or retention of action, or because you’ve got a better appetite as soon as your depression symptoms ease up. Some antidepressants are more likely to cause weight gain. If that is a side effect of this antidepressant if you are worried about weight gain, ask your physician and also talk about methods to tackle this matter.

Consider these strategies:

  • Cut back on sweets and sugary drinks.
  • Select low-fat healthy foods, like fruits and veggies, and steer clear of saturated and polyunsaturated fats.
  • Keep a food journal — monitoring what you eat will help you manage your weight.
  • Seek advice from a registered dietitian.
  • Get regular physical activity or exercise most days of this week.
  • Talk with your physician about changing medications, but find the advantages and disadvantages.

Infection, nausea

Nausea and fatigue are common, particularly.

Consider these strategies:

  • Require a brief nap throughout the day.
  • Get some physical action, like walking.
  • Avoid driving or operating hazardous machinery until the exhaustion moves.
  • Require your antidepressant during pregnancy when your physician prescribes.
  • Talk with your physician to find out if adjusting your dose can help.


Some antidepressants can cause sleeplessness which means you could be tired throughout the day.

Consider these strategies:

  • Require your antidepressant in the daytime when your physician prescribes.
  • Avoid caffeinated food and beverages, especially late in the day.
  • Get regular physical activity or workout — but finish it a few hours before bedtime so that it does not interfere with your sleeping.
  • If sleeplessness is a continuous difficulty, ask your physician about taking a sedating medicine at bedtime or inquire whether choosing a reduced dose of a sedating antidepressant like trazodone or mirtazapine (Remeron) prior to bed may help.


Constipation is frequently connected with antidepressants because they disrupt normal operation of the digestive tract and other organ systems. Other antidepressants cause constipation .

Consider these strategies:

  • Drink plenty of water.
  • Eat high-fiber foods, such as fresh vegetables and fruits, brans, and whole grains.
  • Get regular exercise.
  • Require a fiber supplement (Citrucel, Metamucil, others).
  • Ask your physician for information on stool softeners if other steps do not work.

Dry mouth

Dry mouth is a frequent complication of many antidepressants.

Consider these strategies:

  • Sip water frequently or suck on ice chips.
  • Chew sugarless gum or suck on sugarless hard candies.
  • Avoid smoking, alcohol and carbonated drinks because they are able to make your mouth drier.
  • Breathe through your nose, not your own mouth.
  • Brush your teeth twice daily, floss daily and visit your dentist regularly. Using a dry mouth may increase your chance of getting cavities.
  • Talk with your physician or dentist around over-the-counter or prescription drugs for mouth.
  • If dry mouth is still quite bothersome regardless of the efforts above, ask your doctor the advantages and disadvantages of decreasing the dose of the antidepressant.


Dizziness is more prevalent with tricyclic antidepressants and monoamine oxidase inhibitors (MAOIs) compared to other antidepressants. These medicines can cause low blood pressure.

Consider these strategies:

  • Rise slowly from sitting to standing positions.
  • Use handrails, canes or other hardy items for assistance.
  • Avoid driving or operating machines.
  • Avoid caffeine, alcohol and tobacco.
  • Drink lots of fluids.
  • Require your antidepressant during pregnancy when your physician prescribes.

Agitation, restlessness, nervousness

Restlessness agitation or stress could result in the impact of antidepressants. It might indicate that you can not relax or sit even if you would like to, Though having more energy may be a fantastic thing.

Consider these strategies:

  • Get regular exercise, like running, biking or rowing, or some kind of physical activity, like walking. Speak with your physician about what is a kind of exercise or activity for you.
  • Exercise deep-breathing exercises, muscle relaxation or yoga.
  • Consult your physician about temporarily carrying a relaxing or sedating drug or switching to an antidepressant which is not too stimulating.

Be alert to spontaneous or racing thoughts together with energy. If these grow, speak with your physician straight away because they might be indications of bipolar disorder or another illness.

Heart-related consequences

Based upon your heart health and the kind of antidepressant you require, you might require an electrocardiogram (ECG) before or occasionally during therapy. The ECG can be used to track what is known as the QT interval to be certain it is not prolonged. A prolonged QT interval is a heart rhythm illness that could raise your chance of serious irregular heart rhythms (arrhythmias).

Antidepressants shouldn’t be used if you are taking an MAOI or if you have heart issues. Speak to your physician about your heart health and some other heart medicines you take.

Sexual side effects

Many antidepressants cause side effects. They could include trouble and reduced libido. Some antidepressants can cause difficulty getting or maintaining an erection (erectile dysfunction). Selective serotonin reuptake inhibitors (SSRIs) are more likely to cause sexual side effects compared to other antidepressants are.

Consider these strategies:

  • Take a medicine which needs just a once-a-day dose, and program sexual activity prior to taking that dose.
  • Talk with your physician about switching to an antidepressant which may have fewer of those effects, such as bupropion (Wellbutrin, SR, Wellbutrin XL, others), or correcting your medicine to alleviate unwanted side effects.
  • Talk with your spouse about your sexual side effects and the way they change your wants. Fixing your routine might be beneficial. You might require a duration of foreplay.
  • Speak with your doctor about alternatives for drugs, such as sildenafil (Viagra), that can temporarily alleviate sexual side effects or cure erectile dysfunction and some other related risks. Keep away from over-the-counter herbal nutritional supplements that guarantee increased sexual appetite and function — those aren’t governed by the Food and Drug Administration (FDA) and a few may be harmful to your wellbeing.

Genetic variations

Some studies suggest that variations in enzymes can play a part in risk and the efficacy of unwanted effects of antidepressants that are particular. So that your genes might, at least in part, decide whether a antidepressant will work for you and if you are most likely to get side effects that are specific.

Restricted testing to help determine option is already provided by some places, but testing isn’t regular and it is not covered by insurance.

Studies have been done to ascertain what could be the most effective antidepressant option according to genetic makeup. Genetic testing is part of — not a replacement for — conclusions and a more psychiatric examination.


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