Last Updated on February 19, 2017 by Dr.Derek Fhisher
Most popular brand: Maxaquin
Active ingredient: Lomefloxacin
Available dosage forms: 400 mg
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Lomefloxacin general information
Health-related matters have to be thoroughly discussed to ensure which you are safe utilizing the drug. So as to avoid Maxaquin side effects, you need to follow simply rules and recommendation of your physician and drug manufacturer. To ensure that you’re able to benefit from the benefits of Lomefloxacin, you got to continue utilizing the drug for the length of the prescription. Also inform them if you smoke, drink alcohol, or utilize illegal drugs. In case that one is already taking these, you must stop all such medications, and take medical advice for an individual’s ailment and receive the drugs prescribed, if they’re at all required. Take lomefloxacin carefully as instructed by your doctor.
Oral fluoroquinolones might be secure, effective therapy if they’re given for a prolonged course as treatment for infections brought on by susceptible gram-positive and gram-negative organisms and in conjunction with adequate surgical debridement. Then, take into consideration that patients with impaired renal function are advised to reduce the dose, based on the creatinine clearance. For example, I would suggest levofloxacin in place of other agents when a patient is, in addition, taking warfarin, theophylline, or cyclosporin. Levofloxacin is likewise very beneficial in patient-initiated treatment due to its once-daily administration, and doesn’t have some significant drug-drug interactions, compared to a number of the other fluoroquinolones. The interactions of particular fluoroquinolones ought to be checked ahead of prescription. You might not have the capacity to take lomefloxacin, or perhaps you call for a dosage adjustment or special monitoring during treatment should you be taking some of the medicines listed above.
The FDA categorizes medications predicated on safety to be used when pregnant. Don’t take two doses of the medication unless otherwise instructed by your doctor. Additionally, inform your doctor if you’re pregnant or intend on becoming pregnant during treatment with this particular medicine. Inform your doctor in case you are pregnant or intend on becoming pregnant. Don’t skip doses or quit your medicine early. Before taking Lomefloxacin, you should consult an experienced physician.
Anaerobic bacteria weren’t generally prone to lomefloxacin. It truly is used to treat specific types of bacterial infections. In case the bladder isn’t evacuated frequently, the bacteria will find more time to raise in number within the urine collected within the urinary bladder. It’s not going to work for colds, flu, or alternative infections. These studies meant to learn more about the efficacies of quinolones for healing chronic osteomyelitis brought on by gram-positive bacteria, especially S. aureus. Resolution of infection needed to include things like a healed wound with no drainage or swelling.
Special care might be needed. Actually, it depends on the particular situation of every patient. The therapy schedule really depends on the answer to therapy along with the patient. Previous tendon issues, kidney ailments, liver issues, blood vessel disorders, and epilepsy must be noted. Actually, we must consider the best management for reducing their length of stay when the patient is admitted. This really is certainly associated with reduced costs regarding hospitalization, which is quite an expensive part of a treatment.
Don’t start or stop utilizing any medicine without consulting your own doctor. Call your physician for medical advice regarding side effects. Make sure you inform your doctor of any healthcare conditions you might have, or some family history of health problems. Plus, you must speak with your doctor about your own health care history. Speak to your pediatrician about the use of the medicine in children. Don’t take this medication without first speaking to your doctor if you’re breast-feeding a baby.
Tell your physician or doctor in case your symptoms usually do not improve or get worse. Stop taking this medicine and get in touch with your doctor immediately if you receive a reaction from sunlight. Don’t take your medicine more frequently than directed. If it’s almost time for your subsequent dose, take just that dose. Simply Take this medicine orally with a complete glass of plain water. What’s more, in a feeling, this sort of therapies is the fundamental source of relapse.
The most ordinary symptom of the lomefloxacin overdose is seizures. Whatever the case, urination shouldn’t be postponed, since this will build up the rise of UTI. Keeping a constant quantity drug within your body is essential in its being able to block the growth of the bacteria and eliminating them completely. It is clear that the intake of lots of fluids is required, so that there’s frequent urination, and also the bladder is continually kept clean. This medicine might be taken with food or on a bare stomach. It is suggested you take this medication using a glass of plain water.
The antimicrobial agent the fluoroquinolones. It has bactericidal activity. Inhibits DNA – gyrase – an enzyme involved in transcription and replication of bacterial DNA.
is highly active against aerobic Gram-negative bacteria: Escherichia coli, Salmonella spp. Citrobacter diversus, Enterobacter cloacae, Haemophilus influenzae, Klebsiella pneumoniae, Proteus vulgaris, Morganella morganii, Legionella pneumophila, Neisseria gonorrhoeae, Neisseria meningitidis, Moraxella catarrhalis.
K lomefloxacin moderately sensitive Proteus mirabilis, Proteus stuartii, Providencia rettgeri, Pseudomonas aeruginosa, Serratia liquefaciens, Serratia agglomerans, Haemophilus parainfluenzae, Providencia alcalifaciens, Aeromonas hydrophila, Hafnia alvei, Mycobacterium tuberculosis, Chlamydia trachomatis, and some gram-positive aerobic bacteria ( Staphylococcus aureus, Staphylococcus epidermidis).
To lomefloxacin resistant Streptococcus spp. Pseudomonas cepacia, Ureaplasma urealyticum, Mycoplasma hominis and anaerobic bacteria.
Lomefloxacin have antituberculosis activity, acting both on the outside – and intracellularly located Mycobacterium tuberculosis.
Once inside Lomefloxacin almost completely absorbed from the gastrointestinal tract, absorption is 95 – 98%. Binding to plasma proteins – 10%.
It is widely distributed in the body. Concentration in the tissues and body fluids, typically 2 – 7 times higher than in plasma, especially in the prostate tissue and in urine.
T 1/2 lomefloxacin is 7 – 9 hours Approximately 70 -. 80% is excreted unchanged in the urine within 24 hours.
In patients with impaired renal function T 1/2 is substantially increased.
The infectious – inflammatory diseases caused by microorganisms sensitive to lomefloxacin, including Urinary tract infections (cystitis, pyelonephritis), prostate; infections of the lower respiratory tract; acute and chronic purulent soft tissue infections, infected wounds, osteomyelitis; cholera (severe); tuberculosis (in combination therapy); acute and chronic gonorrhea; acute and recurrent chlamydia.
Prevention of infectious complications of the urinary tract before and after transurethral surgery.
For topical use in ophthalmology: bacterial infections of the front eye section (including conjunctivitis, blepharitis, Blepharoconjunctivitis).
When administered daily dose is 400 – 800 mg, the frequency of administration and duration of treatment set individually.
Topical ophthalmic use 2 – 3 times / day for 7 – 10 days. At the beginning of treatment is recommended more frequent use.
From the digestive system: nausea, vomiting, diarrhea.
From the CNS: headache, anxiety, sleep disorders.
Dermatological reactions: in some cases – photosensitivity, skin rash.
The effects caused by chemotherapeutic action: with prolonged use can candidiasis.
Local reactions: rare – a burning sensation that occurs immediately after instillation.
Pregnancy, lactation (breastfeeding), children and teens up to 15 years, increased sensitivity to quinolone derivative.
Application of pregnancy and breast-feeding
lomefloxacin is contraindicated during pregnancy and lactation (breastfeeding).
Caution should be used in patients with severe cerebral arteriosclerosis, epilepsy and other diseases of the central nervous system.
If the kidney function requires a correction mode, depending on the QC values.
During treatment should avoid prolonged exposure to sunlight and the use of artificial ultraviolet light.
It should not be applied topically in conjunction with antibiotics for use in ophthalmology, acting bacteriostatic.
Vitamins with mineral additives should be used within 2 hours before or 2 hours after administration of lomefloxacin.
It should be borne in mind that when using fluoroquinolones may be peripheral neuropathy; adverse effect on tendon (including gaps) both during and after therapy; cumulation of caffeine, resulting in stimulation of the central nervous system; pseudomembranous colitis; lengthening the interval QT c (risk of ventricular arrhythmias, including such as “pirouette)”.
In an application with antacids and sucralfate formed chelate complexes, which reduces the bioavailability of lomefloxacin (should not take antacids and sucralfate for 4 hours before and 2 hours after taking lomefloxacin).
In an application with rifampicin (tuberculosis patients) observed antagonism of the action.
In an application Lomefloxacin practically does not inhibit the metabolism of theophylline.
With simultaneous use of lomefloxacin and caffeine in high doses may increase the half-life of the latter.
The drugs that block tubular secretion, slow down the excretion of lomefloxacin.
In an application Lomefloxacin increases the activity of oral anticoagulants and increases the toxicity of NSAIDs.
With the simultaneous use of fluoroquinolones with NSAIDs may develop seizures.
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