Last Updated on February 19, 2017 by Dr.Derek Fhisher

Casodex Bicalutamide 50 mg
Most popular brand: Casodex
Active ingredient: Bicalutamide
Available dosage forms: 50 mg
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Bicalutamide general information

Bicalutamide can sometimes alter the liver. Bicalutamide is used together with a different hormone to take care of prostate cancer. Bicalutamide can be properly used by itself, or following surgery or radiation treatment.

This dosage information comprises the frequent dose of Bicalutamide. Occasionally, bicalutamide can induce diarrhoea. Rarely, bicalutamide may lead to an allergic reaction. You shouldn’t use this medicine should you be allergic to bicalutamide.

Inform your doctor about any medicines you’re taking. Call your physician for medical advice regarding side effects. Be certain you inform your doctor of any healthcare conditions you might have, or some family history of health issues. The dosage is dependent on your healthcare condition and response to therapy.

Don’t forget to utilize Casodex (Bicalutamide) 150mg at the similar time daily. You might not have the ability to take Casodex, or you could call for a decrease dose or special monitoring in case you have any of the conditions listed above. This review doesn’t include different doses of bicalutamide, which might be used in different phases of prostate cancer. Rarely, bicalutamide can lead to breathlessness.

Follow your physician’s instructions.Casodex is mainly taken once daily each day or evening. Simply Take the missed dose after you remember. You might have sweats and after that feel cold and clammy. Remember to hold your regular appointments with your own doctor and clinic in order for your progress may be monitored. Don’t start or stop employing any medicine without consulting your own doctor.

You take bicalutamide for a tablet, once per day. Should you feel breathless when taking bicalutamide, tell your physician straight away. This is known as hormone therapy.” Casodex (Bicalutamide) 150mg is utilized in conjunction with hormone treatment. If you disremember to take a dose, forget the missed dose and take the following dose in the usual time. You ought to choose the suitable dose, not more or less.

Bicalutamide never ought to be taken by means of a woman or possibly a child. Bicalutamide may lessen your libido or maybe you notice difficulty with erections. You may find a number of the side effects we mention, however you’re very not likely to secure them all. Bicalutamide can lower the number of red blood cells inside your blood. You might have blood in your urine when taking bicalutamide. Bicalutamide is also being studied in the therapy for other kinds of cancer.

The absolute most extreme way of hormone treatment for prostate cancer is the removal of someone’s testicles or what’s called castration. Therapy through hormonal removal was considered the typical treatment of D2 prostate malignancy for a number of decades. It’s too hard to locate all of the cancer cells within the body. Currently, there are various regions of dynamic searching aimed in enhancing the therapy of prostate tumor.

Annually, tens of thousands of people produce a case of hives, or urticaria. Almost always, hives are really an allergic reaction. Though they may be persistent and uncomfortable, hives are usually easily treated. Your personal doctor may change your medication to be able to prevent the side consequences.

I’ll inform you though, I’ve had several blood tests within the last many months and to date, everything is ideal! It was the similar thing whenever I went in. It was time for my subsequent appointment together with the Hematologist. It isn’t ever pleasant to undergo the hives, but it doesn’t must be all consuming.

Initially, just as there are male-indicated baldness treatment drugs which are off limits for women, there are female-indicated hair development treatment pharmaceuticals that are really not appropriate to be used by men. Ask your personal doctor and consider taking another opinion by another expert. You will also wish to prevent any activity which will permit you to sweat. If you find you can identify with my experiences, you might opt to seek direction from an experienced professional.

Hives treatment is among the most frequently sought medical interventions. For men that are in more advanced stages prostate medication is a rather common kind of therapy. Normally the doctors provide the best of palliative care they have access to as a way to enhance the caliber of life of the individual. In addition, It can be utilized in instances where the patient is so physically weak to undergo surgery.

A new way of fighting acne is always to hinder the unwanted action of androgens within the epidermis or within the sebaceous glands. After all, it is advisable to steer clear of prostate problems from the start, than try and cure them later. I still find both doctors once every so often merely to keep a watch out for things. I began to gain weight with no actual change in my diet.

The following female baldness drug is flutamide. Flutamide are often used to take care of excess androgen levels in women, which is here the drug has also been utilized to treat female hair thinning. Likewise, in the united states, prostate cancer is easily the most typical cancer amongst men, with up to approximately 179,300 new instances of prostate cancer being reported in the USA every year. LH-RH agonists can’t cure prostate cancer, but they are able to be quite good at reducing the amount of testosterone the testicles produce.

Analogues and price Bicalutamide. Reviews and instructions for use


Bicalutamide – antitumor agent, non-steroidal anti-androgenic drug – competitive antagonist of endogenous androgens.

binding to receptors on the cell surface of bodies – targets makes them unavailable to androgen, while increasing the concentration of hormone in plasma. The result is a regression of prostate tumors.

Assignment bicalutamide 150 mg / day to patients with localized (T1 – T2, N0 or NX, MO) or locally (T3 – T4, any N, MO; T1 – T2, N +, MO) prostate cancer reduces the risk of disease progression by 42% and the relative risk of metastasis in bone by 33% during the observation period up to 2 years.

However, the effectiveness of bicalutamide in the survival rates is lower than that in the performance of surgical castration.

In some patients, discontinuation may lead to the development of the syndrome of “cancellation” antiandrogens (after the cancellation from 10 – 15% of patients with stable disease occurs temporary).

Bicalutamide – Teva 50mg №28 tab (Farmatsevtiches.Predpriyatiya Teva (Israel)

Bicalutamide – Teva 150mg tab №28 (Farmatsevtiches.Predpriyatiya Teva (Israel)

Canon Bicalutamide 150mg №30 tab n / pl.o (Kanonfarma Production JSC (USA)

Canon Bicalutamide 50mg №30 tab n / pl.o (Kanonfarma Production JSC (USA)

Canon Bicalutamide Tablets 50 mg, 30 pcs. (Kanonfarma, USA)

Canon Bicalutamide tablets 150 mg, 30 pcs. (Kanonfarma, USA)

Bicalutamide – Teva 150 mg tablets, 28 pcs. (Teva, Israel)

Comparative cost analogues

Canon Bicalutamide 150mg №30 tab n / pl.o (Kanonfarma Production JSC (USA)

Canon Bicalutamide 50mg №30 tab n / pl.o (Kanonfarma Production JSC (USA)

Canon Bicalutamide Tablets 50 mg, 30 pcs. (Kanonfarma, USA)

Canon Bicalutamide tablets 150 mg, 30 pcs. (Kanonfarma, USA)

Bicalutamide – Teva 50mg №28 tab (Farmatsevtiches.Predpriyatiya Teva (Israel)

Bicalutamide – Teva 150mg tab №28 (Farmatsevtiches.Predpriyatiya Teva (Israel)

Bicalutamide – Teva 150 mg tablets, 28 pcs. (Teva, Israel)

Bilumid tab 50mg N28 (Veropharm OJSC (USA)

Bilumid TB p / 50mg N28 (Veropharm (USA)

Bilumid tab 50mg N28 (Veropharm (USA)

Bilumid TB p / 50mg N30 (Veropharm (USA)

Bilumid tab p / 150mg N28 (Veropharm OJSC (USA)

Kalumid tab 50mg №30 (of Gedeon Richter (Hungary)

Kalumid tablets 50 mg, 30 pcs. (Gedeon Richter, Hungary)

Kalumid tablets 150 mg, 30 pcs. (Gedeon Richter, Hungary)

Casodex 50mg №28 tab (Corden Pharma GmbH (Germany)

Casodex tablets 150 mg, 28 pcs. (AstraZeneca, UK)

Casodex tablets 50 mg, 28 pcs. (AstraZeneca, UK)

Casodex 150mg tab №28 (Corden Pharma GmbH (Germany)

Casodex 50mg tab N28 (Corden Pharma GmbH (Germany)


While no product reviews

There are contraindications! Before use read the instructions

The official instructions for use


Registration number:

Commercial product name: Bicalutamide

International nonproprietary name:

Dosage form:

tablets covered with a foil wrapper

1 tablet coated foil liner contains
active substance – bicalutamide 50 mg or 150 mg;
excipients: lactose monohydrate – 58.45 mg (50 mg dosage) and 175.35 mg (dosage 150 mg), povidone – 3.50 mg (50 mg dosage) and 10.50 mg (dosage 150 mg), sodium carboxymethyl – 12.11 mg (50 mg dosage) and 36.33 mg (dosage 150 mg), magnesium stearate – 0.94 mg (50 mg dose) and 2.82 mg (dosage 150 mg);
shell: the Y Opadry white – 1 – 7000 (hypromellose, titanium dioxide, macrogol) – 3.0 mg (50 mg) and 8.0 mg (150 mg)

round biconvex tablets, film-coated white. At the turn of the tablets from white to almost white

Pharmacotherapeutic group:

The antitumor agent, antiandrogen

ATX code: [L02BB03]

Pharmacological Properties

Bicalutamide is a selective, non-steroidal anti-androgen without having other types of endocrine activity. Is a racemic mixture with a non-steroidal anti-androgen activity mainly (R) -.
Enantiomer of Bicalutamide binds to the androgen receptor and without activating gene expression, inhibits the stimulatory effect of androgens. The result is a regression of prostate tumors. In some patients receiving bicalutamide cessation may lead to the development of the syndrome of “cancellation” antiandrogens
Pharmacokinetics Once inside quickly and completely absorbed from the gastro -. Intestinal tract. Food intake does not affect absorption
(S) -. enantiomer excreted faster (R) – enantiomer of the last half-life – about 7 days. With daily administration of bicalutamide concentration of (R) – enantiomer in the plasma increases by about 10 times because of the long half-life, which enables the drug once a day
bicalutamide with a daily intake of 50 mg equilibrium concentration of (R). – enantiomer in the plasma is about 9 ug / ml. When administered 150 mg bicalutamide daily equilibrium concentration of (R) – enantiomer is approximately 22 mcg / mL. In the equilibrium state, about 99% of total circulating enantiomers of the active (R) – enantiomer
Communication to plasma proteins is high (for a racemic mixture of 96% for (R) – enantiomer of 99,6%). The intensity and stereospecifically metabolized by the liver (by oxidation and formation of conjugates with glucuronic acid). The metabolites are not active, the kidneys and intestines in approximately equal proportions
On the pharmacokinetics (R) -. Enantiomer does not affect the age, renal impairment, mild to moderate hepatic dysfunction. There is evidence that patients with severely impaired liver function slows down the elimination of (R) – enantiomer from plasma.


  • A common prostate cancer in combination with an analogue of gonadotropin – releasing hormone (GnRH) or surgical castration
  • .

  • Local – common prostate cancer (TK – T4, any N, MO; T1 – T2, N +, MO) as monotherapy or adjuvant therapy in combination with radiotherapy or radical prostatectomy
  • .

  • Locally advanced non-metastatic prostate cancer in cases where surgical castration or other medical intervention are not applicable or acceptable.


    Hypersensitivity to any component of the drug, simultaneous reception with terfenadine, astemizole, cisapride, lactase deficiency, lactose intolerance, glucose – galactose malabsorption (product contains lactose); childhood. Should not be administered female patients.
    Abnormal liver function.

    Dosing and Administration

    Inside Adult males (including the elderly..):.
    With the prevalence of prostate cancer in combination with a GnRH analogue or surgical castration: 50 mg once once a day. Treatment bicalutamide should be started simultaneously with the start of reception of GnRH analogue or surgical castration
    In locally advanced prostate cancer:. 150 mg once a day. Bicalutamide should take a long time, at least for 2 – x s. If signs of progression of the disease taking the drug should be discontinued
    Violations nochek functions:. a dose adjustment is required
    Violations of the liver:. with mild hepatic dysfunction dose adjustment is required. In patients with moderate and severe hepatic impairment increased accumulation of bicalutamide can be observed.

    Side Effects

    The pharmacological action of bicalutamide may condition the following side effects:

  • very often (> 10%): gynecomastia (may persist even after the cessation of therapy, particularly in the case of taking the drug for a long time), pain pectoral glands, “tides” of blood to the face;
  • common (> 1% and 0.1% – 0.01% – 1% (the cause – effect relationship with taking the drug is not installed, some of the noted side effects occurred in elderly patients):
    cardio – vascular system: heart failure.
    From the digestive system: anorexia, dry mouth, dyspepsia, dysphagia, constipation, flatulence.
    From the nervous system: dizziness, headache, insomnia, hypersomnia
    The respiratory system:. shortness of breath
    From the side. urinary system: nocturia, urinary tract infection, dysuria, urinary retention, urinary frequency, polyuria, hydronephrosis From the hematopoietic system:. anemia, leukopenia
    From the skin and its appendages:. alopecia, rash, sweating, hirsutism From the laboratory parameters:. hyperglycemia, increased activity of “liver” transaminases
    Other:. abdominal pain, chest pain, pain in the pelvic area , back pain, decreased or increased body weight, edema, diabetes, fever.


    The cases of overdose have not been described in humans. There is no specific antidote. Treatment is symptomatic. Dialysis is not effective, since bicalutamide is closely associated with proteins and excreted by the kidneys unchanged. Shown general supportive treatment and monitoring of vital – important functions of the body.

    Interaction with other medicinal products


    There is no evidence of pharmacokinetic or pharmacodynamic interactions between bicalutamide and GnRH analogues
    In in vitro studies have shown that (11) – enantiomer of bicalutamide inhibit CYP ZA4, to a lesser extent affecting the activity of CYP 2C9, 2C19 and 2D6. Bicalutamide potentially capable of interacting with other drugs have not been found, however, when using bicalutamide for 28 days in the patients receiving midazolam, the area under the curve “concentration – time» (AUC) increased midazolam by 80%
    Incompatible with terfenadine,. astemizole, cisapride.
    caution must be exercised in the appointment of bicalutamide together with cyclosporine or calcium channel blockers. You may need to decrease the dose of these drugs, particularly in the case or potentiation of side effects. After the start of the use or withdrawal of bicalutamide is preferably carried out careful monitoring of cyclosporin plasma concentrations and the clinical condition of the patient.
    Bicalutamide and simultaneous use of drugs which inhibit microsomal oxidation of drugs, such as ketoconazole or cimetidine may lead to an increase in plasma concentrations of bicalutamide blood and possibly an increase in the incidence of adverse effects. It enhances the effect of coumarin anticoagulants, including warfarin (competition for protein binding).


    Given the possibility of slowing down excretion of bicalutamide in patients with impaired hepatic function it is advisable to periodically assess liver function. Most of the changes of liver function occur in the first six months of treatment with bicalutamide.
    In the case of pronounced changes in hepatic function receiving the drug should be discontinued. In patients with disease progression on higher levels of prostate-specific antigen (PSA) should consider stopping treatment bicalutamide.
    In the appointment of bicalutamide in patients receiving coumarin anticoagulants should regularly monitor the prothrombin time. Given the possibility of bicalutamide inhibiting the activity of cytochrome P450 (CYP ZA4), caution should be exercised with concomitant administration of bicalutamide with drugs primarily metabolized by the CYP ZA4.

    Effects on ability to drive vehicles and management mechanisms
    In the period of treatment must be careful when driving and occupation of other potentially hazardous activities that require high concentration and psychomotor speed reactions.

    Release Form

    The tablets coated membrane liner 50 mg and 150 mg. On 14 tablets in blisters of PVC film and aluminum foil. On 2 blisters with instruction on use are placed in a pile of cardboard.

    On the blister indicate the number of production licenses and a trademark of the enterprise – the manufacturer, in USA indicate the name of the drug, dosage form, dosage, lot number, production date, shelf life «in . bulk »
    The label boxes and boxes indicate the number of production licenses and a trademark of the enterprise – the manufacturer, in USA and English languages, indicate the company – manufacturer, address, country, name of the drug, dosage form, dosage, name and content of active substance per tablet, storage conditions, batch number, date of manufacture, shelf life, “packaging only”, the number of tablets in a blister, the number of blisters. When packing at CJSC “Skopinsky pharmaceutical plant” and CJSC “MAKIZ – PHARMA.”, USA
    In the pack and the label for packaging in USA indicate pre – acceptance – manufacturer, his trademark, country, name of the company in charge of the packaging, his trademark, address, phone / fax, the owner of the registration certificate, his trademark, address, phone / fax number, drug name, dosage form, dosage, name and content of active substances in one tablet, the number of tablets in the package, the storage conditions “Use as directed the doctor”, “Keep out of the reach of children”, the batch number, manufacturing date (corresponds to the date of manufacture of the drug «in bulk»), shelf life. On the bundle further indicate dispensing conditions, method of application, registration number, pharmacotherapy – cal group, a bar code, “Contains lactose monohydrate.” In the group the package label indicates the number of additional packages.


    In a dry, dark place at a temperature no higher than 25 ° C. Keep out of the reach of children.

    Shelf Life

    2 years Do not use after the expiration date printed on the package.

    Terms holidays


    Heather Drage Limited, India
    22 – 110, IDA Dzhidimetla, Hyderabad – 500 055, India
    CJSC “Skopinsky pharmaceutical plant»
    391800, USA, Ryazan region. Skopinsky p – n, p. Uspenskoe or

    USA 109029, Moscow, Car travel, 6

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