Last Updated on February 19, 2017 by Dr.Derek Fhisher
Most popular brand: Trecator-SC
Active ingredient: Ethionamide
Available dosage forms: 250 mg
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Ethionamide general information
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An important caution in the utilization of ethionamide is the fact that patients should strictly obey the drug therapy to stop complications and drug resistance. The dosage of the drug depends on the patient’s own body weight. Viagra is a medicine, therefore it can be utilized only with caution. Any medication can induce death if overdosed. Other medicines for tuberculosis are utilized in conjunction with ethionamide. The use ethionamide alone might result in rapid maturation of drug resistance.
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ETHIONAMIDE 250mg is an antibiotic that’s used to take care of tuberculosis infections. Horse chestnut is generally combined with several other herbs that improve circulation, like bilberry and gingko. Coconut oil one of the top things it’s possible to apply directly in your skin and hair.
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Clupeotoxin poisoning is among the most serious conditions that could produce metallic taste within the mouth. Post-nasal drip can lead to a change within the taste too. Food allergies too can cause a metal-like taste within the mouth, together with some other allergy symptoms. In addition, the capacity of creating resistance must be taken under consideration.
Code J. Antimicrobials for systemic use
The thioamide derivative of isonicotinic acid. TB drugs II series. Yellow crystalline powder with low or moderate sulfur odor. Not hygroscopic. Practically insoluble in water and air; it is soluble in the ethyl and methyl alcohol, propylene glycol; soluble in acetone, dichloroethane; freely soluble in pyridine. Molecular weight 166,25.
The pharmacological action.
Tuberculosis (pulmonary and extrapulmonary, in case of intolerance or ineffectiveness of anti-TB drugs I series, including a part of complex therapy tuberkulostaticheskoy).
Hypersensitivity, including isoniazid, pyrazinamide, nicotinic acid and other similar chemical structure of the drug, acute gastritis, gastric ulcer and duodenal ulcer, ulcerative colitis, liver cirrhosis and other liver diseases in acute, chronic alcoholism, kidney failure, age up to 14 years.
for use Limitations.
Diabetes mellitus, epilepsy, liver disease is worsening (increases risk of hepatotoxicity).
Application of pregnancy and breastfeeding.
is contraindicated in pregnancy. Ethionamide passes through the placenta. In experimental studies on animals (rabbits, rats) demonstrated teratogenic effects at doses higher than recommended for humans.
At the time of treatment is recommended not to breastfeed (it is not known whether ethionamide passes into breast milk).
From the nervous system and sensory organs: neurological and psychiatric disorders – headache, paresthesia, seizures, decreased concentration, confusion, drowsiness or insomnia, fatigue, depression, hallucinations, agitation, psychosis , peripheral neuritis, optic neuritis.
From the digestive tract: anorexia, metallic taste in the mouth, stomatitis, salivation, belching a rotten smell, nausea, vomiting, epigastric pain, diarrhea, flatulence, abnormal liver function (hepatotoxicity up to development of hepatitis).
On the part of cardio – vascular system and blood (blood, hemostasis): tachycardia, orthostatic hypotension, a violation of the blood (thrombocytopenia).
Allergic reactions: skin rash, urticaria, exfoliative dermatitis.
Other: gynecomastia, dysmenorrhea, impotence, hypothyroidism, hypoglycemia in patients with diabetes, hypovitaminosis B 6 . weight loss, arthralgia, photosensitivity.
When used in conjunction with other anti-TB agents shown synergy in relation to the main action. Together with the admission cycloserine increases the risk of neurotoxic effects, such as seizures (particularly in patients with neurological disease in history), with isoniazid, rifampicin and pyrazinamide – the risk of hepatotoxicity. Enhances the toxic effect of alcohol.
Dosage and administration.
Inside, 30 minutes after eating, drinking milk or orange juice. Adults: 250 mg 3-4 times a day; the maximum daily dose – 1.0 g; patients older than 60 years with a body weight less than 50 kg – 250 mg 2 times a day. Children over 14 years: daily dose – at the rate of 10-20 mg / kg / day, but not more than 750 mg / day. Duration of treatment – 1-2 years.
Before treatment is necessary to study the gastrointestinal tract and liver, as well as the determination of the sensitivity of the selected strain of mycobacteria. During treatment should be every 2-4 weeks to monitor the level of activity of hepatic transaminases, conduct eye examination, patients with diabetes – regular monitoring of blood glucose levels.
In a joint application with pyrazinamide requires more frequent monitoring of liver function. The combined use of inappropriate prothionamide of – the presence of the cross-resistance of Mycobacterium tuberculosis to these drugs. Avoid concurrent use with drugs having hepatotoxic effect.
should be combined with nicotinamide (0.1 g 2-3 times a day) and vitamin B 6 (1-2 ml of 5% solution / m) to prevent the side effects of ethionamide.
At the time of treatment should refrain from drinking alcohol. Be wary of the drivers of vehicles and people whose work requires high concentration of attention.