Last Updated on February 19, 2017 by Dr.Derek Fhisher

Trental Pentoxifylline 400 mg
Most popular brand: Trental
Active ingredient: Pentoxifylline
Available dosage forms: 400 mg
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Pentoxifylline general information

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on the application of the drug Pentoxifylline Guide

General on the preparation

Pentoxifylline refers to a group of antiplatelet agents, and Adenozinergicheskie angioproektornyh drugs. Pentoxifylline has pronounced vasodilating and agnioproektivnoe impact, improves microcirculation. The drug helps to improve the tone of respiratory muscles, to stop the processes of thrombosis. Pentoxifylline is used in the case of atherosclerosis of brain vessels, cerebrovascular disease, diabetic nefroangiopatii, vascular pathologies of the visual apparatus, as well as violations of the peripheral circulation.

1. Pharmacological action

The drug, which improves blood circulation and has a protective effect on the vascular wall due to a decrease in blood viscosity, increase the flexibility of red blood cells, vasodilatory action and reduce the ability of platelets to form complexes.

During the application Pentoxifylline patients has been a general improvement in the state of internal organs and tissues caused by an increase in the volume of inflowing blood and oxygen level. In addition, there have been improvements bioelectric processes in the brain and restore blood circulation in the areas of violations.

Pentoxifylline well absorbed. His neutralization occurs in the liver, removal of decay products – with urine and feces.

2. indications for use

  • Violations of circulation in the limbs;
  • Violations of blood circulation in the brain;
  • Stroke. due to lack of blood supply to the brain;
  • Post-stroke state;
  • Prevention of infringements of blood circulation at neuroinfections;
  • Disorders of the circulatory system;
  • Circulatory disorders of hearing;
  • Asthma;
  • Impotence caused by circulatory failure;
  • myocardial infarction.

3. How to use

Pentoxifylline Recommended dosage for oral administration:
On the two pills three times a day before the onset of relief, then – one pills three times a day. Duration of treatment – two weeks.

The recommended dosage in the form of injections:

  • Intravenous preparation: 1 ampoule drug dissolved in 250 – 500 ml of saline or glucose solution. Duration of administration – one and a half – three hours. Perhaps an increase in the daily dosage of medication to 3 ampoules per day;
  • [intraarterial administration: 1 ampoule of the drug dissolved in 20 – 50 ml of saline. Perhaps an increase in dosage to 3 ampoules per day. the introduction of speed – 0.5 ml per minute
  • .

Features of the application:

  • Patients suffering from functional disorders of the liver or kidney, dosage adjustment is required;
  • During treatment with pentoxifylline requires constant monitoring of blood pressure levels.

The information on the application is made in accordance with the instructions from the manufacturer

4. Side effects

  • Violations of the haematopoietic system (reduced white blood cell count, decreased platelet count, decreased levels of all blood cells);
  • Disorders of the nervous system (various sleep disorders, headaches, causeless anxiety, dizziness, convulsions);
  • Violations of cardio – vascular system (increased pain in the heart, heart rhythm disorders, low blood pressure);
  • The violation of the digestive system (a decrease or complete loss of appetite, feeling of dry mouth, decreased muscle tone of the intestines, the aggravation of gall bladder inflammation, elevated liver enzymes, inflammation of the liver caused by stagnation of bile);
  • Violations of the blood coagulation system (reduction in fibrinogen, bleeding of various localization);
  • Violations of the senses (the appearance of the site with the absence of various disorders of visual perception);
  • Violations of the skin and its derivatives (redness of the skin, increased fragility of nails, flushing and chest);
  • Various allergic reactions (angioedema. Pruritus, anaphylactic shock. Urticaria. Reddening of the skin of various localization).

5. Contraindications

  • Porphyry;
  • Violation of the blood supply to the heart muscle in the acute form;
  • Heavy bleeding;
  • Individual intolerance Pentoxifylline or its components;
  • Bleeding in the brain;
  • An uncontrolled decrease in blood pressure;
  • Pregnancy and lactation;
  • Cardiac arrhythmias;
  • retinal hemorrhage;
  • Hypersensitivity to pentoxifylline or its components;
  • Atherosclerotic cardiac arteries;
  • violations of atherosclerotic arteries of the brain.

6. During pregnancy and lactation

The use of Pentoxifylline during pregnancy is strictly contraindicated.

The use of pentoxifylline during lactation is possible only in exceptional cases after the compulsory cessation of breast-feeding during treatment.

7. Interaction with other medicinal products

In an application with Pentoxifylline.

  • drugs to lower blood pressure, increase in action last observed;
  • With the simultaneous use of pentoxifylline injection with insulin, an increase in the therapeutic effect of insulin;
  • Ketolorakom with meloxicam or lead to the development of bleeding;
  • drugs, having the ability to dilate blood vessels, drugs that weaken the transmission of nerve impulses in the peripheral nervous system and drugs that suppress the transmission of nerve impulses in the nerve nodes, leads to a decrease in blood pressure;
  • heparin marked increase in the therapeutic effect of the latter, aimed at reducing the blood’s ability to clot;
  • cimetidine Pentoxifylline increases the plasma concentration and the development of relevant side effects.

8. Overdose

  • Violations of cardio – vascular system (a sharp decrease in blood pressure, redness of the skin);
  • Disorders of the nervous system (convulsions, drowsiness, severe emotional agitation, confusion);
  • Violations of the digestive system (internal bleeding);
  • Various violations of state (fevers).

No specific antidote to pentoxifylline no. If you have these symptoms, you need to conduct manipulations aimed at restoring normal blood pressure and prevention of respiratory arrest. When seizures recommended the appointment of Diazepam in the required dosage.

9. Release Form

Tablets 100 mg -. 10, 20, 30, 40, 50 or 60 pieces
tablets with an extended therapeutic effect, 400 mg – 10, 20, 30, 40, 50 pieces
solution. for injections in ampoules of 2 mg / ml – 100 ml container; 100 mg / 5 ml – Valium. 5 or 10 pieces; 20 mg / 1 ml – Valium. 3, 5, 6, 9, 10, 12, 15, 20, 30 or 40 pieces; 40mg / 2ml – Amp. 3, 5, 6, 9, 10, 12, 15, 20, 30 or 40 pieces; 100 mg / 5 ml – Valium. 3, 5, 6, 9, 10, 12, 15, 20, 30 or 40 pieces; 2% (100 mg / 5 ml) – Amp. 10 pieces
Concentrate, 100 mg / 5 ml -. Amp. 5,10 or 20 pieces; 20 mg / 1 ml – 5 ml ampoules. 5 or 10 pieces; 20 mg / ml – 5 ml ampoules. 5 or 10 pcs.

10. Storage Conditions

Pentoxifylline should be stored in a dry, dark place, eliminating the access of children and unauthorized persons.

Recommended temperature range – no more than 25 degrees.

Recommended term storage – various printed on the package with the product.

11. Ingredients

1 ml:

  • pentoxifylline – 2 mg;
  • Other ingredients: sodium chloride, water.

1 ml:

  • pentoxifylline – 20 mg;
  • Other ingredients: sodium chloride, sodium dihydrogen phosphate dihydrate, sodium hydroxide solution, water.
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