Last Updated on February 19, 2017 by Dr.Derek Fhisher
Most popular brand: Pletal
Active ingredient: Cilostazol
Available dosage forms: 50, 100 mg
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Cilostazol general information
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Cilostazol: A new drug lameness
In January 1999, the US Department of the Food and Drug Administration approved the cilostazol (brand name: PLETAL) management of intermittent claudication, a condition in which pain develops in the legs while walking and sometimes at rest. This follows from the narrowing of the arteries that supply the muscles of the legs with blood and oxygen.
Cilostazol does not cure intermittent claudication but rather reduces the pain so that patients could go longer before developing pain. In 8 studies, the mean distance healing foot was 28 – 100% of patients who took cilostazol compared with – 10 to 30% for patients who took placebo (" sugar pill ").
Do not completely known how cilostazol works. Its primary action is to expand the arteries going to the legs, increasing the flow of blood and oxygen to the muscles. It also reduces the blood’s ability to clot.
So far, pentoksifilin (TRENTAL) was the only drug approved for the management of intermittent claudication. TRENTAL improves blood flow, making it easier for red blood cells, which carry oxygen to travel through the arteries and reducing the " stillness " (Viscosity) of blood.
Cilostazol (PLETAL) is a tablet which is taken twice a day. The most common adverse effects – headache, rapid or abnormal heartbeat, stomach pain, diarrhea, nausea and dizziness.
Patients with heart failure should not use cilostazol (PLETAL), because long-term use of drugs such as Pletal among patients with heart failure was associated with occasional deaths.