• Primidone general information

      • Medicine “primidone”: instructions for use and feedback

      • The composition, shape and packaging

      • Action medication

      • Kinetic properties

      • Indications for use

      • Contraindications to receive medication

      • Medicine « primidone »: instructions for use

      • Side Effects

      • Cases of overdose

      • Compatibility with other medicines

      • Special Considerations

      • Similar tools

      • Testimonials

Mysoline Primidone 250 mg
Most popular brand: Mysoline
Active ingredient: Primidone
Available dosage forms: 250 mg
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Primidone general information

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Medicine “primidone”: instructions for use and feedback

December 28, 2015

Modern pharmaceutical companies produce a large number of antiepileptics. How to understand the variety of drugs? To do this, refer to the experienced. He will be able to choose for you the most effective medicine, which will contribute to significant endowment of the patient.

The most popular antiepileptic drugs among patients and physicians is medication « primidone ». Instructions for use of said drugs, its shape and properties of the release will be presented a little lower.

The composition, shape and packaging

To get the medicine « primidone » It can be in two different forms. It comes in powder form, which is packed in a plastic bag and a dual-layer cardboard box, respectively. Also, this tool is available in the form of tablets in blister packs and cartons.

The active ingredient in this drug acts primidone. Also it consists of adjuvants (depending on the release form).

Action medication

What is the medicine « primidone »? Instructions for use indicate that this antiepileptic drug. It promotes mild hypnotic effect, but also reduces the excitability of neurons that are located in the epileptic focus.

What other properties are inherent medicament « primidone »? Essential tremor when it eliminates blood concentration of 12 pg / ml.

Kinetic properties

The drug is « primidone » (Tablets and powder) is quite fast and almost fully absorbed from the gastrointestinal tract. The highest concentration of the drug is achieved after three hours. The bioavailability of the drug is 90 – 100%. In the blood it binds to proteins slightly (approximately 20%).

The half-life time of the tool is 7 – 15 hours.

In the liver medication partially converted to phenobarbital (about 20%) and feniletilmalonamid. These metabolites possess antiepileptic activity. They excreted by the kidneys.

The patient’s blood is necessary to maintain therapeutic drug concentration equal to 12 mg / ml. Such indicators contribute to slowing seizures. When other forms of epilepsy (eg, non-convulsive forms, polymorphous seizures and other) the effect of the therapy is not always achieved. In this case, the complex treatment.

Indications for use


In some cases, the patient is prescribed medication such as « primidone »? Reviews have reported that this tool effectively treats epilepsy of various origins, as well as partial and generalized seizures. With the development of focal, myoclonic and akinetic seizures, this medicine less effective.

Contraindications to receive medication

In some cases, do not prescribe medication « primidone »? Instructions for use of reports that it is forbidden to use means in the presence of a hypersensitivity (including barbiturates), as well as anemia, liver and kidney failure, pregnancy, breastfeeding, and leukopenia.

Medicine « primidone »: instructions for use

In what dosage prescribed medication we are considering? It is taken orally after meal consumption in a single one-time dose of 125 mg. After that, every three days, said the amount of drug increased by 250 mg for adult patients and 125 mg for children who have reached 9 – age.

This therapy is continued until the desired result.

The maximum daily dose for children is 1 g (in two stages), and for adult ; 1.5 g.

Side Effects

Unfortunately, we are considering antiepileptic drug often causes undesirable effects. These include excessive sleepiness, headaches, dizziness, anxiety, lethargy, nausea, anemia, vomiting, leukopenia, allergic reactions, and lymphocytosis.

Very rarely this medicine can cause nystagmus, ataxia, « lupus » syndrome, psychotic reactions, arthralgia, megaloblastic anemia, and prolonged use ; drug dependence.

Cases of overdose

Taking large doses of the drug can cause symptoms such as dizziness, ataxia, nausea, and depression of the central nervous system work. For the treatment of such conditions the patient was washed stomach, activated charcoal and symptomatic treatment.

Compatibility with other medicines

The drug is « primidone » derivatives enhances the effect of cyclophosphamide, methotrexate and sulfonylureas as well as hypnotics. It also speeds up the metabolism, increases the activity of hepatic microsomal enzymes, reduces the effect of corticosteroids, paracetamol, ISS, tricyclic antidepressants, anticoagulants, “Chloramphenicol”, “DTIC”, “Cyclosporine” cardiac glycosides “disopyramide”, ” levothyroxine », « Doxycycline », « theophylline », « metronidazole », « Quinidine », « mexiletine », vitamin D, « fenoprofen », caffeine, « Aminophylline » and « Okstrifillina ».

Considered medication enhances CNS depression when combined with funds from the central depremiruyuschim action and alcohol.

The drug is « Amphetamine » slows the absorption of phenobarbital.

When combined with carbonic anhydrase inhibitors amplified osteopenia.

This reduces the absorption of griseofulvin agent that reduces its antifungal activity. It also enhances the toxic effects « enflurane », « methoxyflurane » and « halothane ».

« Methylphenidate » promotes inhibition of metabolism and primidone increase its concentration in the blood.

« leucovorin » in large doses reduces the effect of anticonvulsant primidone. The same applies to the drug « phenylbutazone ».

Special Considerations

The drug is « primidone » It can be used in complex anticonvulsant treatment. Canceled, as well as replacement of the drug is carried out gradually.

With the utmost care, he was appointed the elderly and immunocompromised people. With the development of megaloblastic anemia medication overturned and prescribe vitamin B12 or folic acid.

Considered a means of reducing human psychomotor reactions. Therefore, it does not prescribe the drivers of vehicles and people whose work is connected with dangerous machinery.

Be wary this medication is used in children.

Similar tools

How can replace the drug « primidone »? Analogues of this tool can be purchased at any pharmacy or order through the World Wide Web.

According to the experts’ opinion, similar properties are such medicines as « hexamidine », « Benzonal » and « Phenobarbital ».


Consumers are taking this antiepileptic drug as « primidone », left him only positive feedback. According to their reports, the drug copes well with its task. It prevents the occurrence of partial and generalized seizures. Also, this medicine helps to reduce the symptoms of epilepsy.

As for the negative reviews, almost all of them point to the fact that this tool contributes to the emergence of a large number of side effects. Therefore, apply this remedy should only be for the purpose of the doctor.

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