Last Updated on February 19, 2017 by Dr.Derek Fhisher
Most popular brand: Ansaid
Active ingredient: Flurbiprofen
Available dosage forms: 200 mg
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Flurbiprofen general information
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From the digestive system: dyspepsia (nausea, vomiting, heartburn, diarrhea), NSAID – gastropathy, abdominal pain, abnormal liver function; long-term use at high doses – ulceration of the gastrointestinal mucosa, bleeding (gastro – intestinal, haemorrhoidal, gums).
Cardio – vascular system: increased blood pressure, tachycardia, cardiac failure.
From the hematopoietic system: , rarely – anemia (iron deficiency, hemolytic, aplastic), agranulocytosis, leukopenia, thrombocytopenia.
From the central and peripheral nervous system: headache, dizziness, drowsiness or insomnia, fatigue, depression, amnesia, tremor, agitation, rarely – ataxia, paraesthesia, disturbance of consciousness.
From the urinary system: tubulointerstitial nephritis, edema syndrome, renal failure.
Allergic reactions: skin rash, pruritus, urticaria, bronchospasm, photosensitivity, angioedema, anaphylactic shock.
Other: hearing loss, tinnitus, increased sweating.
The local application in ophthalmology: burning, irritation of the conjunctiva.
Erosive – ulcerative lesions of the gastrointestinal tract in the acute phase, “aspirin triad” (bronchial asthma, vasomotor rhinitis, intolerance of acetylsalicylic acid), pregnancy, lactation, hypersensitivity to NSAIDs, heart failure, edema, hypertension, hemophilia, anticoagulation, hepatic failure, chronic renal failure, hearing loss, vestibular pathology, deficiency of glucose – 6 – phosphate dehydrogenase, inhibition of bone marrow hematopoiesis, early childhood.
Not applicable rectally in inflammatory diseases of the rectum and perianal area.
The local application in ophthalmology: hypersensitivity, herpetic keratitis.
Pregnancy and breastfeeding
Flurbiprofen is contraindicated during pregnancy and lactation (breastfeeding).
Application for violations of liver function
is contraindicated in hepatic impairment.
Application for violations of renal function
is contraindicated in chronic renal failure.
Use in children
is contraindicated in early childhood.
To use caution in congenital hyperbilirubinemia (Gilbert syndrome, Dubin – Johnson and Rotor).
Flurbiprofen can prolong bleeding time, which increases the risk of bleeding from the gastrointestinal tract, particularly during chronic administration.
The greatest therapeutic effect is achieved while taking flurbiprofen in the morning and evening hours. While receiving flurbiprofen needs periodic monitoring picture peripheral blood and bleeding time.
If you want to define 17 – ketosteroidov drug should be discontinued 48 hours prior to the study.
When applied topically in the form of eye drops for people with a history of herpetic keratitis requires additional monitoring of patients. In applying the drug may be cases of delayed scarring of wounds, as well – cross-sensitivity to acetylsalicylic acid and other NSAIDs.
Effects on ability to drive vehicles and management mechanisms
During the treatment should refrain from activities potentially hazardous activities that require attention and speed of mental and motor responses.
Inductors microsomal oxidation in the liver (phenytoin, ethanol, barbiturates, rifampicin, phenylbutazone, tricyclic antidepressants) increase the production of hydroxylated active metabolites.
With simultaneous use of flurbiprofen reduces the effectiveness of uricosuric drugs, enhances the effect of anticoagulants (increased risk of bleeding), antiplatelet agents, fibrinolytic agents, the side effects of mineralocorticoids, corticosteroids, estrogens; reduces the effectiveness of antihypertensive and diuretics; enhances the hypoglycemic effect of sulfonylurea derivatives.
acetylsalicylic acid increases the concentration of drug in plasma, ranitidine – reduces.
antacids and cholestyramine reduce the absorption of flurbiprofen.
With simultaneous use of flurbiprofen in the blood increases the concentration of lithium preparations, methotrexate.
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