Last Updated on February 19, 2017 by Dr.Derek Fhisher
Most popular brand: Flagyl
Active ingredient: Metronidazole
Available dosage forms: 200, 400 mg
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Metronidazole general information
Women intending to utilize metoprolol should tell their physician ahead of time if they’re pregnant, or designing to find pregnant. Whenever you have to undergo all sorts of surgery, you need to essentially inform your surgeon beforehand which you’re taking metoprolol. People taking metoprolol must receive their blood pressure taken frequently and, therefore, it is important you should drop by your physician on a normal basis. Steer clear of alcohol while on metoprolol as it could boost drowsiness or dizziness. Metoprolol tartrate is not suggested for individuals with heart failure. Never quit taking metoprolol suddenly.
In case you’re taking metoprolol for healing high blood pressure (hypertension), it truly is advisable you ought to follow the advised diet religiously, utilize this prescription drug regularly in addition to follow exercise schedules closely. Alcohol might interact with metoprolol by raising the risk and asperity of the medication’s side consequences. A mix of alcohol and metoprolol might also increase drowsiness, potentially impairing someone’s thinking and reactions. You really need to keep on taking metoprolol for remedying hypertension even after you can feel better after starting treatment with this specific medication. Beta blockers for example metoprolol should probably not be viewed as first-line remedies for high blood pressure (1,2).
Common prescribed medications may lead to a shortfall of fur on your own head. Its can be taken with insulin however your own doctor may supply you with different dosage instructions to make certain that no terrible things occur. Numerous different drugs are associated with unusual weight changes. There are a varied types of side effects of the drug and they might not really be the exact same in all patients.
Slimming down is often as easy as a few developments in the diet, including a slight decline in the quantity of fat. When Metformin hcl is utilized in combination that has a good diet and superior exercise habits there isn’t any way that positive results won’t occur. Other method to reduce weight gain may just be adding exactly the same modalities people without medical problems utilize to treat their obesity. Actually weight loss was reported.
In accordance with experts, the degree of TSH hormone vary during the various phases of pregnancy. Following are the complications that could arise as a result of hyperthyroidism. The hormones generated by the thyroid are extremely essential at cellular level. Wellbutin is an anti-depressant that’s not in the SSRI group and doesn’t trigger weight gain.
Exercise self-empowerment by seeking another opinion. Ask a number of individuals who will inform you the reality. There are numerous resources on the internet and also offline, that make dedicated research possible 24×7. With a rather limited supply and quite a substantial demand it certainly costs a good deal.
Get in touch with a reputable healthcare practitioner if you’re in need of health care. This not simply causes numerous health difficulties but in addition results within the speeding up of the aging practice. Right now, if he’s made no improvement, the physician fears that he is going to be adding diabetes medications too. While this is among the important causes, the very best news is it is very treatable in men and women.
Sudden unexplained loss isn’t normal. Exercise controls the weight and might help to decrease the blood pressure. Selective beta blockers usually do not cause, as much issue, as non-selective ones. Should you happen to see a gain of three or four pounds within a period of a few days, you must inform your doctor about it.
- International nepatentovanoe name
- The Latin name
- Pharmaceutical Group
Wed – wa for lechen.trihomonoza, amebiasis and other
Flags, Trichopolum, Ginalgin, Clione, Orvagil, Atrivil, Klont, Efloran, Entizol, FLEG Filmet, Ginefvlafir, metronome, Metrogil, Trihazol, Triheks, Trikotset, Trick , Trivazol, Vagimid, Zoatsid, Nidozol, Protalit, Aponitronidozol, Kamezol, Medazol, Novonidazol, Protamet, Rozamet, Flyunidazol, Karnidazol.
1 – (b – hydroxyethyl) – 2 – methyl – 5 – nitroimidazole. Metronidazole – white or slightly greenish crystalline powder. It is soluble in water, it is difficult – in alcohol. Tablets contain 0.25, and 0.5 g of metronidazole. Vaginal suppositories containing 0.5 g of metronidazole. 100 ml of solution contain: metronidazole – 0.5 g; Other ingredients: sodium chloride, disodium salt of ethylenediaminetetraacetic acid, water for injections
- Indications for use
Protozoal infections: extra-intestinal amebiasis, including amebic liver abscess, intestinal amebiasis (amebic dysentery), trichomoniasis, giardiazis, balantidiasis, giardiasis, cutaneous leishmaniasis, Trichomonas vaginitis Trichomonas urethritis. Infections caused by Bacteroides spp. (Including Bacteroides fragilis, Bacteroides distasonis, Bacteroides ovatus, Bacteroides thetaiotaomicron, Bacteroides vulgatus): bone and joint infections, CNS infections, including meningitis, brain abscess, bacterial endocarditis and pneumonia, empyema and lung abscess, sepsis. Infections caused by species of Clostridium spp. Peptococcus and Peptostreptococcus: abdominal infections (peritonitis, liver abscess), pelvic infections (endometritis, abscess of the fallopian tubes and ovaries, vaginal cuff infection). Pseudomembranous colitis (involving the use of antibiotics). Gastritis or ulcer 12 – duodenal ulcer associated with Helicobacter pylori. Prevention of postoperative complications (especially interventions on the colon, okolorektalnoy area apendektomiya, gynecological operations). Radiotherapy patients with tumors – as radiosensitizing drugs in cases where resistance is caused by hypoxia in the tumor cells, tumor
- Mode of action
antiprotozoal and antimicrobial drug, a derivative of 5 – nitroimidazole. The mechanism of action consists in biochemical restoration of 5 – nitro group of metronidazole by intracellular transport proteins of anaerobic microorganisms and protozoa. The recovered 5 – nitro metronidazole interacts with DNA microbial cells by inhibiting synthesis of nucleic acids, which leads to the death of the bacteria. It is active against Trichomonas vaginalis, Entamoeba histolytica, Gardnerella vaginalis, Giardia intestinalis, Lamblia spp. and obligate anaerobes Bacteroides spp. (Including Bacteroides fragilis, Bacteroides distasonis, Bacteroides ovatus, Bacteroides thetaiotaomicron, Bacteroides vulgatus), Fusobacterium spp. Veillonella spp. Prevotella (Prevotella bivia, Prevotella buccae, Prevotella disiens) and some Gram-positive microorganisms (Eubacter spp. Clostridium spp. Peptococcus spp. Peptostreptococcus spp.). IPC for these strains is 0.125 – 6.25 g / ml. In combination with amoxicillin is active against Helicobacter pylori (amoxicillin suppresses the development of metronidazole resistance). Metronidazole-insensitive aerobic microorganisms and facultative anaerobes, but in the presence of mixed flora (aerobes and anaerobes) metronidazole acts synergistically with antibiotics effective against usual aerobes. Increases the sensitivity of tumors to radiation causes a reaction disulfiramopodobnye stimulates reparative processes.
- How to use
The powder for solution for intravenous infusion solution, oral suspension, tablets, vaginal tablets, film-coated tablets:
oral and parenteral. Inside, during or after eating (or drinking milk), not liquid. Trichomoniasis – 250 mg 2 times a day for 10 days or 400 mg two times a day for 5 – 8 days. Women must also appoint metronidazole in the form of vaginal suppositories or tablets. If necessary, repeat the treatment or increase the dose to 0.75 – 1 g / day. Between courses should take a break at 3 – 4 weeks to conduct repeated control laboratory tests. An alternative regimen is the appointment of 2 g once a patient and his sexual partner. Children 2 – 5 years – 250 mg / day; 5 – 10 years – 250 – 375 mg / day over 10 years – 500 mg / day. The daily dose should be divided into 2 doses. The course of treatment – 10 days. Giardiasis – 500 mg 2 times a day for 5 – 7 days. Children under 1 year – 125 mg / day, 2 – 4 years – on 250 mg / day, 5 – 8 years – 375 mg / day over 8 years – 500 mg / day (2 admission). The course of treatment – 5 days. When giardiazise – 15 mg / kg / day in 3 divided doses for 5 days. Adults: asymptomatic amoebiasis (the detection of cysts) daily dose – 1 – 1.5 g (500 mg 2 – 3 times a day) for 5 – 7 days. In chronic amoebiasis daily dose – 1.5 g in 3 divided doses for 5 – 10 days, in case of acute amoebic dysentery – 2.25 g in 3 divided doses until the symptoms cease. When liver abscess maximum daily dose – 2.5 g per 1 or 2 – 3 divided doses, for 3 -. 5 days, in combination with antibiotics (tetracycline) and other therapies. Children 1 – 3 years – 1/4 of the adult dose, 3 – 7 years – 1/3 of the adult dose, 7 – 10 years – half the adult dose. When balantidiasis – 750 mg three times daily for 5 – 6 days. In ulcerative stomatitis adults appoint 500 mg 2 times a day for 3 – 5 days; children in this case, the drug is not shown. When pseudomembranous colitis – 500 mg of 3 – 4 times daily. For eradication of Helicobacter pylori – 500 mg 3 times a day for 7 days (combination therapy, combination with amoxicillin for example 2.25 g / d). In the treatment of anaerobic infections maximum daily dose – 1.5 – 2 in the treatment of chronic alcoholism appoint 500 mg / day for a period of up to 6 (not more) months. For the prevention of infectious complications – at 750 – 1500 mg / day in 3 divided doses for 3 – 4 days before the operation or a single 1 g in the first day after surgery. After 1 – 2 days after surgery (already enabled when the reception inside) – 750 mg / day for 7 days. When severe impaired renal function (creatinine clearance less than 10 ml / min) daily dose should be reduced by 2 times. Oral suspension. Anaerobic bacterial infections: children – 7 mg / kg every 8 hours, the course of treatment – 7 – 10 days; giardiasis: children 2 – 5 years – 200 mg / day, 5 – 10 years – 300 mg / day, 10 – 15 years – 400 mg / day. The duration of treatment of giardiasis – 5 days. The course of treatment can be repeated after 10 – 15 days parenterally. Adults and children over 12 years at an initial dose of 0.5 – 1 g / drip (infusion duration – 30 – 40 minutes), and then every 8 hours, 500 mg at a rate of 5 ml / min. With good endurance after the first 2 – 3 infusion switch to bolus. The course of treatment – 7 days. If necessary / introduction is continued for a longer time. The maximum daily dose – 4 g According to the testimony make the transition to support the ingestion of a dose of 400 mg 3 times a day. Children under 12 years: in the same way in a single dose – 7.5 mg / kg. When purulent – septic diseases usually spend 1 course of treatment. As a preventive measure for adults and children over 12 years: intravenously the drip, 0.5 – 1 g before surgery, on the day of surgery and the next day – 1.5 g / day (500 mg every 8 hours). After 1 – 2 day pass to a maintenance therapy in. Patients with chronic renal failure and CC less than 30 ml / min and / or hepatic insufficiency, the maximum daily dose – not more than 1 g, the multiplicity of reception – 2 times a day. The drugs administered as a radio / drip rate of 160 mg / kg or 4 – 6 g / m body surface of 0.5 – 1 hour before irradiation. Apply before each irradiation for 1 – 2 weeks. The remainder of the radiation treatment of metronidazole is not applicable. The maximum single dose should not exceed 10 g, course – ’60 to remove the intoxication caused by irradiation, used drip of 5% dextrose solution, gemodez or 0.9% NaCl solution. In cervical cancer and uterine body, cancer of the skin is used as local applications (3 g was dissolved in 10% DMSO solution), moistened tampons, which are used topically for 1.5 – 2 hours prior to irradiation). In case of bad application of the regression of the tumor was carried out for the entire course of radiation therapy. If the positive dynamics of the purification of tumor necrosis – within the first 2 weeks of treatment.
The gel vaginal, vaginal suppositories, vaginal tablets:
intravaginally, once 2 g or as a course of treatment at 500 mg / day, 2 times a day (morning and evening) for 10 days. During the course of treatment should avoid sexual intercourse.
The gel is for external use, cream for external use:
Apply on clean skin with a thin layer 2 times a day, morning and evening, for 3 – 9 weeks. If necessary, impose occlusive dressing. Applying a cream and gel can be alternated. The average duration of treatment is 3 – 4 months, the therapeutic effect is usually observed after 3 weeks of treatment
Enhances the effects of indirect anticoagulants and lithium salts. Phenobarbital and phenytoin decrease the effect (due to activation of the liver microsomal system and accelerate metabolism and excretion), and cimetidine enhances (inhibits enzyme system of the liver and, consequently, slows biotransformation). Incompatible with alcohol (antabuspodobny syndrome develops in a joint reception).
Hypersensitivity, leukopenia (including in the anamnesis), organic lesions of the central nervous system (including epilepsy), hepatic failure (in the case of the appointment of large doses) pregnancy (I trimester), lactation. Pregnancy (II – III trimesters), renal / hepatic failure. Drug Interactions.
increases the effects of anticoagulants, which leads to increased formation of prothrombin time. Similarly, disulfiram causes intolerance of ethanol. Concomitant use with disulfiram may lead to the development of a variety of neurological symptoms (interval between administration – not less than 2 weeks). Metronidazole for i / v administration is not recommended to mix with others. PM. Metronidazole, cimetidine inhibits metabolism, which may lead to an increase in its concentration in the serum and an increased risk of side effects. Simultaneous administration of drugs, enzymes stimulating hepatic microsomal oxidation (phenobarbital, phenytoin), may accelerate the elimination of metronidazole, resulting in decreases its concentration in plasma. When concomitantly with drugs Li + may increase plasma concentration of the latter in the development and symptoms of intoxication. Do not combine with non-depolarizing muscle relaxants (vecuronium bromide). Sulfonamide enhance the antimicrobial action of metronidazole.
From the digestive system: diarrhea, loss of appetite, nausea, vomiting, intestinal colic, constipation, “metallic” taste in the mouth, dry mouth, glossitis, stomatitis, pancreatitis. From the nervous system: dizziness, impaired coordination of movements, ataxia, confusion, irritability, depression, irritability, fatigue, insomnia, headache, seizures, hallucinations, peripheral neuropathy. Allergic reactions: urticaria, skin rash, redness of the skin, nasal congestion, fever, arthralgia. From the urinary system: dysuria, cystitis, polyuria, urinary incontinence, candidiasis, urine staining in red – brown color. Local reactions: thrombophlebitis (pain, redness or swelling at the injection site). Other: neutropenia, leukopenia, flattening of the T wave in the ECG
The symptoms: nausea, vomiting, ataxia, in severe cases – peripheral neuropathy and epileptic pripadki.Lechenie: symptomatic; There are no specific antidotes.
In the treatment of metronidazole is sometimes observed excessive development of fungal vaginal flora (candidiasis), which requires the appointment of antifungal drugs.
The gel is for external use, cream for external use, vaginal gel, vaginal suppositories, vaginal tablets, powder for solution for intravenous infusion solution, suspension for receiving administration, tablets, film-coated tablet.
List B. In the dark spot.
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